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Cognıtıve functıons in idiopathic intracranial hypertensıon

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Abstract

Objective

Cognitive problems in idiopathic intracranial hypertension (IIH) is generally overlooked in the presence of disabling headache and threat to visual function. The aim of this study was to search for cognitive deficits in patients with IIH using neuropsychologic tests in addition to P300 potential recordings to assess cognition related brain activity.

Methods

Fifty IIH patients were examined using Montreal Cognitive Assessment Test, Stroop Test and Visual Aural Digit Span Test to measure different domains of cognition at the time of diagnosis. P300 potentials were recorded by using an oddball paradigm. Hospital Anxiety and Depression Scale was used to determine anxiety and depression. Quality of life (QoL) was assessed by SF-36. The results were compared with fifty healthy controls with matching age, gender and body mass index.

Results

Neuropsychologic tests revealed wide cognitive impairment including attention, working memory, executive function, naming, language, delayed recall and orientation in IIH patients. In addition, quality of life was affected in the sub-parameters of general health perceptions, emotional role functioning, vitality, mental health and bodily pain. P300 potential latencies were long and the amplitudes were reduced indicating deficits in attention and working memory. Anxiety scores were high, and health-related QoL was low mainly involving vitality, emotional and mental health. Cognitive dysfunction was not correlated with the levels of anxiety and the correlation with headache severity was mild.

Conclusion

A multidomain cognitive decline mainly involving attention and working memory was recorded in IIH patients. It was not correlated with anxiety and only a mild correlation with headache severity was present which may indicate a casual relationship between raised intracranial pressure and cognitive deficits. Screening is important as neuropsychological rehabilitation might be relevant in these patients.

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Authors and Affiliations

  1. Department of Neurology, Celal Bayar University, 45000, Manisa, Turkey

    Ayşın Kısabay Ak, Aysegül Seyma Sarıtas, Melike Batum, Yagmur Inalkac Gemici & Burak Karakaş

  2. Department of Neurology, Ege University, Bornova, 35000, Izmir, Turkey

    Neşe Çelebisoy

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  1. Ayşın Kısabay Ak
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  2. Aysegül Seyma Sarıtas
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  3. Melike Batum
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  4. Yagmur Inalkac Gemici
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  5. Burak Karakaş
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Correspondence to Neşe Çelebisoy.

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Ethical approval

The study protocol was approved by the Manisa Celal Bayar University Medical School Ethics Committee (reference number: 11/ 08 / 2021 / 20.478.486 / 898) and was performed under the ethical standards outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants.

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Ak, A.K., Sarıtas, A.S., Batum, M. et al. Cognıtıve functıons in idiopathic intracranial hypertensıon. Acta Neurol Belg (2024). https://doi.org/10.1007/s13760-024-02550-9

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