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Anti-spastic effect of contralesional dorsal premotor cortex stimulation in stroke patients with moderate-to-severe spastic paresis: a randomized, controlled pilot trial

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Abstract

Objective

This study aimed at investigating the effect of a single-session repetitive transcranial magnetic stimulation (rTMS) of the contralesional dorsal premotor cortex on poststroke upper-limb spasticity.

Material and methods

The study consisted of the following three independent parallel arms: inhibitory rTMS (n = 12), excitatory rTMS (n = 12), and sham stimulation (n = 13). The primary and secondary outcome measures were the Modified Ashworth Scale (MAS) and F/M amplitude ratio, respectively. A clinically meaningful difference was defined as a reduction in at least one MAS score.

Results

There was a statistically significant change in MAS score within only the excitatory rTMS group over time [median (interquartile range) of − 1.0 (− 1.0 to − 0.5), p = 0.004]. However, groups were comparable in terms of median changes in MAS scores (p > 0.05). The proportions of patients achieving at least one MAS score reduction (9/12 in the excitatory rTMS group, 5/12 in the inhibitory rTMS group, and 5/13 in the control group) were also comparable (p = 0.135). For the F/M amplitude ratio, main time effect, main intervention effect, and time–intervention interaction effect were not statistically significant (p > 0.05).

Conclusions

Modulation of the contralesional dorsal premotor cortex with a single-session of excitatory or inhibitory rTMS does not appear to have an immediate anti-spastic effect beyond sham/placebo. The implication of this small study remains unclear and further studies into excitatory rTMS for the treatment of moderate-to-severe spastic paresis in poststroke patients should be undertaken.

Clinical trial registration no

NCT04063995 (clinicaltrials.gov).

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  1. Department of Physical Medicine and Rehabilitation, School of Medicine, İzmir Kâtip Çelebi University, Basın Sitesi Mahallesi Gazeteci Hasan Tahsin Caddesi, İzmir, Turkey

    İlker Şengül, Ayhan Aşkın, Aylin Altun & Aliye Tosun

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Şengül, İ., Aşkın, A., Altun, A. et al. Anti-spastic effect of contralesional dorsal premotor cortex stimulation in stroke patients with moderate-to-severe spastic paresis: a randomized, controlled pilot trial. Acta Neurol Belg 123, 1345–1354 (2023). https://doi.org/10.1007/s13760-023-02212-2

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