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Evaluation of serum thiol-disulphide homeostasis parameters as oxidative stress markers in epilepsy patients

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Abstract

The present study focuses on the investigation of the dynamic thiol-disulphide homeostasis in patients with epilepsy and understanding the effects of antiepileptic drugs on thiol levels. A total of 148 participants, 75 of whom had epilepsy and 73 were healthy volunteers, were included in the study. Total thiol and native thiol levels of all epilepsy patients and healthy volunteers were measured. Disulphide level, disulphide/native thiol, disulphide/total thiol and native/total thiol ratios were calculated from these values. The results were compared between epilepsy patients and healthy volunteers. A statistically significant difference was found between native thiol level, total thiol level, disulphide level, disulfide/total thiol, disulphide/native thiol and native/total thiol ratios between patients with epilepsy and healthy volunteers (p = 0.002, p = 0.035, p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively). The drugs used had a significant effect on disulphide, disulphide/total thiol, native/total thiol levels (p values 0.004, 0.009, 0.009, respectively). Decreased levels of serum native, total thiol and increased disulfide levels as parameters of oxidative stress may be considered as parameters to explain the pathogenesis or consequences of epilepsy.

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Authors and Affiliations

  1. Clinical Biochemistry Laboratory, Ministry of Health Ankara City Hospital, Ankara, Turkey

    Arzu Kösem, Sevilay Sezer & Turan Turhan

  2. Department of Medical Biochemistry, Gulhane Military Medical Academy|GATA, Ankara, Turkey

    Çiğdem Yücel

  3. Neurology Clinic, Ministry of Health Ankara City Hospital, Ankara, Turkey

    Ayşe Pınar Titiz

  4. Department of Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey

    Salim Neşelioğlu & Özcan Erel

Authors
  1. Arzu Kösem
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  2. Çiğdem Yücel
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  3. Ayşe Pınar Titiz
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  4. Sevilay Sezer
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  5. Salim Neşelioğlu
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  7. Turan Turhan
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Correspondence to Sevilay Sezer.

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The manuscript was approved by the (Ankara Numune Training and Research Hospital Ethics Committee with Protocol Number: E 16-998.).

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Kösem, A., Yücel, Ç., Titiz, A.P. et al. Evaluation of serum thiol-disulphide homeostasis parameters as oxidative stress markers in epilepsy patients. Acta Neurol Belg 121, 1555–1559 (2021). https://doi.org/10.1007/s13760-020-01410-6

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  • DOI: https://doi.org/10.1007/s13760-020-01410-6

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