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Evaluation of retinal microvasculature and foveal avascular zone by the optical coherence tomography angiography in pediatric migraine patients

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Abstract

To compare the foveal avascular zone (FAZ), macular and peripapillary vessel density and retinal nerve fiber layer (RNFL) thickness between pediatric migraine patients and healthy subjects. A total of 108 eyes of 54 children with migraine without aura and 94 eyes of 47 age- and gender-matched healthy subjects were included. Capillary vessel density (CVD) in superficial (SCP) and deep (DCP) retinal capillary plexus, peripapillary region, FAZ, and RNFL thickness were analyzed by optical coherence tomography-angiography. The mean ages were 12.4 ± 3.3 years (range 6–18) in patients with migraine and 12.6 ± 2.9 years (range 5–18) in healthy controls (p = 0.742). The mean FAZ area measured 0.27 ± 0.09 mm2 in the pediatric migraineurs and 0.26 ± 0.09 mm2 in healthy controls (p = 0.53). There was no significant difference in any measurement of SCP, DCP, peripapillary CVD, and RNFL thickness between study groups (p > 0.05 for all). The pediatric migraine disability assessment test (PedMIDAS) negatively correlated with some of the CVD and RNFL measurements in pediatric migraine patients (p < 0.05). The macular and peripapillary microvasculature were not significantly different during an attack-free period in pediatric migraine patients than in healthy subjects.

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Authors and Affiliations

  1. Department of Ophthalmology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Mimar Sinan Mah Emniyet Cad Polis Okulu Karşısı, Yıldırım, 16310, Bursa, Turkey

    Gamze Dereli Can

  2. Department of Ophthalmology, Bursa City Hospital, Bursa, Turkey

    Mehmet Erol Can

  3. Department of Pediatric Neurology, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Turkey

    Arzu Ekici

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  1. Gamze Dereli Can
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  2. Mehmet Erol Can
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  3. Arzu Ekici
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Correspondence to Gamze Dereli Can.

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Dereli Can, G., Can, M.E. & Ekici, A. Evaluation of retinal microvasculature and foveal avascular zone by the optical coherence tomography angiography in pediatric migraine patients. Acta Neurol Belg 121, 1449–1455 (2021). https://doi.org/10.1007/s13760-020-01325-2

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  • DOI: https://doi.org/10.1007/s13760-020-01325-2

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