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Experimental and theoretical studies of the interactions of some synthetic food dyes with human serum albumin

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Abstract

The interaction of 10 synthetic food dyes with human serum albumin (HSA) was investigated using fluorescence spectroscopy, biopartitioning micellar chromatography (BMC) and molecular docking studies. The results obtained by fluorescence spectroscopy indicated that these dyes could strongly quench the intrinsic fluorescence of HSA due to interaction with Trp-214 residue of HSA. The binding constant (Kb) and the number of HSA binding sites were calculated using modified Stern–Volmer equation. BMC as a micellar mobile phase is used as an in vitro system by polyoxyethylene 23 lauryl ether (Brij-35) to predict the Kb of food dyes to HSA. The relationship between the BMC retention data and Kb of food dyes was modeled and the predictive ability of model evaluated. The correlation coefficient (R) and standard error (SE) of developed model were 0.928 and 1.994, respectively. Moreover, molecular docking explorations show that interaction occurs in the subdomain IIA (site I) of HSA.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

    Parvin Hoseyni, Mohammad Hossein Fatemi, Mohammadreza Hadjmohammadi & Seyedeh Maedeh Majidi

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  1. Parvin Hoseyni
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  2. Mohammad Hossein Fatemi
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  3. Mohammadreza Hadjmohammadi
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  4. Seyedeh Maedeh Majidi
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Correspondence to Mohammad Hossein Fatemi.

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Hoseyni, P., Fatemi, M.H., Hadjmohammadi, M. et al. Experimental and theoretical studies of the interactions of some synthetic food dyes with human serum albumin. J IRAN CHEM SOC 19, 885–892 (2022). https://doi.org/10.1007/s13738-021-02351-4

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