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Synthesis and biological evaluation of some 3H-quinazolin-4-one derivatives

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Abstract

Starting from 3-phenylquinazoline-2,4(1H,3H)-dithione, some new derivatives of 3H-quinazoline-4-ones were synthesized. The structures of all new compounds were inferred based on the mass spectral, infrared, and NMR spectral data as well as the elemental analytical data. Some compounds were chosen for testing their biological activities as antibacterial, antifungal, and anticancer agents.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Tanta University, Tanta, 31527, Egypt

    Afrah Sharaf & Ahmed A. Elbarbary

  2. Faculty of Science, Jazan University, 2097, Jazan, Jizan, 45142, Saudi Arabia

    Afrah Sharaf

  3. Photochemistry Department, Chemical Industries Research Division, National Research Centre (NRC), El behouth Street, Dokki, Giza, 12622, Egypt

    Sherif Shaban Ragab

  4. Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, El behouth Street, Dokki, Giza, 12622, Egypt

    Elkhabiry Shaban

  5. Chemistry Department, Faculty of Science, Menoufia University, Shebin Elkom, Egypt

    Ibrahim El Tantawy El Sayed

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  1. Afrah Sharaf
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  2. Sherif Shaban Ragab
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  3. Ahmed A. Elbarbary
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Correspondence to Sherif Shaban Ragab or Ahmed A. Elbarbary.

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Sharaf, A., Ragab, S.S., Elbarbary, A.A. et al. Synthesis and biological evaluation of some 3H-quinazolin-4-one derivatives. J IRAN CHEM SOC 19, 291–302 (2022). https://doi.org/10.1007/s13738-021-02315-8

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  • DOI: https://doi.org/10.1007/s13738-021-02315-8

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