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A novel ionic liquid based electrochemical sensor for detection of pyrazinamide

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Abstract

In this work, we report electrochemical detection of pyrazinamide at the surface of a glassy carbon electrode fabricated with a sensing nanocomposite comprising silver nanoparticles, 1-ethyl-3-methylimidazolium tetrafluoroborate ([Emim][BF4]) ionic liquid, and reduced graphene oxide. The electrochemical reaction of the pyrazinamide at the fabricated electrode was measured using cyclic and differential pulse voltammetric methods. Ionic liquid-reduced graphene oxide-silver nanoparticles were successfully synthesized and characterized by transmission electron microscope and Fourier transform infrared spectroscopy, respectively. The synthesized silver nanoparticles were spherical in shape with an average size of ~ 30 nm. The fabricated electrode exhibits excellent electrocatalytic utility with favourable electrochemical parameters for the reduction of pyrazinamide in acidic media, with optimized pH of 6.0 at an operational potential of − 0.82 V (vs. SCE). The transmission electron microscopy results for the fabricated surfaces demonstrated the formation of nanoscale structures, representing successful electrodeposition and electro-polymerization processes to modify the glassy carbon electrode surface. Moreover, these results showed a linear electrochemical response to pyrazinamide within the concentration in the interval ranging from 3 to 24 µM, with the detection limit and limit of quantification of 0.0102 µM and 0.3658 µM. The fabricated sensor proved high selectivity and sensitivity for pyrazinamide, which made it possible to determine pyrazinamide in pharmaceutical formulations.

Graphic abstract

Schematic illustration of the steps involved in the preparation of ionic liquid-reduced graphene oxide-silver nanoparticles-glassy carbon electrode for the electrochemical detection of pyrazinamide.

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References

  1. R. Chokkareddy, Fabrication of sensors for the sensitive electrochemical detection of anti-tuberculosis drugs, Doctoral dissertation 2018

  2. R. Chokkareddy, N.K. Bhajanthri, G.G. Redhi, Biosensors 7, 21 (2017)

    Article  Google Scholar 

  3. W. H. Organization (2016)

  4. J. van den Boogaard, G.S. Kibiki, E.R. Kisanga, M.J. Boeree, R.E. Aarnoutse, Antimicrob. Agents Chemother. 53, 849 (2009)

    Article  Google Scholar 

  5. S. Mani, S. Cheemalapati, S.-M. Chen, B. Devadas, Int. J. Electrochem. Sci. 10, 7049 (2015)

    CAS  Google Scholar 

  6. M. Khuhawar, F. Rind, J. Chromatogr. B 766, 357 (2002)

    Article  CAS  Google Scholar 

  7. P. Nagaraja, K.S. Murthy, H. Yathirajan, Talanta 43, 1075 (1996)

    Article  CAS  Google Scholar 

  8. N.B. Simioni, T.A. Silva, G.G. Oliveira, O. Fatibello-Filho, Sens. Actuators B Chem. 250, 315 (2017)

    Article  CAS  Google Scholar 

  9. J. Madan, A. Dwivedi, S. Singh, Anal. Chim. Acta 538, 345 (2005)

    Article  CAS  Google Scholar 

  10. H.M. Maher, R.M. Youssef, Chemometr. Intell. Lab. Syst. 94, 95 (2008)

    Article  CAS  Google Scholar 

  11. P. Nahid, M. Pai, P.C. Hopewell, Proc. Am. Thorac. Soc. 3, 103 (2006)

    Article  CAS  Google Scholar 

  12. S. Tafazoli, M. Mashregi, O’brien PJ. Toxicol. Appl. Pharmacol. 229, 94 (2008)

    Article  CAS  Google Scholar 

  13. C.J. Bhanushali, A.S. Zidan, Z. Rahman, M.J. Habib, AAPS PharmSciTech 14, 1313 (2013)

    Article  CAS  Google Scholar 

  14. P. Ioannou, Talanta 34, 857 (1987)

    Article  CAS  Google Scholar 

  15. A.F. Faria, M.V. De Souza, R.E. Bruns, M.A. De Oliveira, Talanta 82, 333 (2010)

    Article  CAS  Google Scholar 

  16. H.C. Goicoechea, A.C. Olivieri, J. Pharm. Biomed. Anal. 20, 681 (1999)

    Article  CAS  Google Scholar 

  17. R. Chokkareddy, N. Bhajanthri, G.G. Redhi, D.G. Redhi, Curr. Anal. Chem. 14, 391 (2018)

    Article  CAS  Google Scholar 

  18. S. Laurent, D. Forge, M. Port, A. Roch, C. Robic, L. Vander Elst, R.N. Muller, Chem. Rev. 108, 2064 (2008)

    Article  CAS  Google Scholar 

  19. A.T. Smith, A.M. LaChance, S. Zeng, B. Liu, L. Sun, Nano Mater. Sci. 1, 31 (2019)

    Article  Google Scholar 

  20. D.R. Dreyer, S. Park, C.W. Bielawski, R.S. Ruoff, Chem. Soc. Rev. 39, 228 (2010)

    Article  CAS  Google Scholar 

  21. X. Li, Y. Liu, L. Zheng, M. Dong, Z. Xue, X. Lu, X. Liu, Electrochim. Acta 113, 170 (2013)

    Article  CAS  Google Scholar 

  22. R. Chokkareddy, N. Thondavada, B. Kabane, G.G. Redhi, in Green Metal Nanoparticles: Synthesis, Characterization and their Applications, chap 6 (Wiley+Scrivener Publishing LLC, USA, 2018), p. 165

  23. R. Chokkareddy, G.G. Redhi, in Green Metal Nanoparticles: Synthesis, Characterization and Their Application, chap 4 (Wiley+Scrivener Publishing LLC, USA, 2018), p. 113

  24. M. Soylak, E. Yilmaz, Desalination 275, 297 (2011)

    Article  CAS  Google Scholar 

  25. E. Yilmaz, M. Soylak, Talanta 116, 882 (2013)

    Article  CAS  Google Scholar 

  26. J. Abraham, J. Thomas, N. Kalarikkal, S.C. George, S. Thomas, J. Phys. Chem. B 122, 1525 (2018)

    Article  CAS  Google Scholar 

  27. R. Chokkareddy, N. Thondavada, N.K. Bhajanthri, G.G. Redhi, Anal. Methods 11, 6204 (2019)

    Article  CAS  Google Scholar 

  28. D.V. Chernyshov, N.V. Shvedene, E.R. Antipova, I.V. Pletnev, Anal. Chim. Acta 621, 178 (2008)

    Article  CAS  Google Scholar 

  29. H.A. Yu, J. Lee, S.W. Lewis, D.S. Silvester, Anal. Chem. 89, 4729 (2017)

    Article  CAS  Google Scholar 

  30. M. A. Zevenbergen. D. Wouters. V.-A. T. Dam. S. H. Brongersma, M. Crego-Calama, Ionic-liquid based electrochemical ethylene sensor, IEEE (2011)

  31. J.Y. Song, B.S. Kim, Bioprocess Biosyst. Eng. 32, 79 (2009)

    Article  Google Scholar 

  32. R. Chokkareddy, N.K. Bhajanthri, G.G. Redhi, Int. J. Electrochem. Sci. 12, 9190 (2017)

    Article  CAS  Google Scholar 

  33. R. Chokkareddy, N.K. Bhajanthri, G.G. Redhi, Indian J. Chem. A 57(A), 895 (2018)

    Google Scholar 

  34. P. Devaraj, P. Kumari, C. Aarti, A. Renganathan, J. Nanotechnol. 2013, 598328 (2013)

    Google Scholar 

  35. M.A.M. Khan, S. Kumar, M. Ahamed, S.A. Alrokayan, M.S. AlSalhi, Nanoscale Res. Lett. 6, 434 (2011)

    Article  Google Scholar 

  36. A. Bathinapatla, S. Kanchi, P. Singh, M.I. Sabela, K. Bisetty, Biosens. Bioelectron. 67, 200 (2015)

    Article  CAS  Google Scholar 

  37. S. Atapattu, C. Tellambura, H. Jiang, IEEE Trans. Wireless Commun. 10, 1232 (2011)

    Article  Google Scholar 

  38. M.F. Bergamini, D.P. Santos, M.V.B. Zanoni, J. Electroanal. Chem. 690, 47 (2013)

    Article  CAS  Google Scholar 

  39. B. Devadas, S. Cheemalapati, S.-M. Chen, M.A. Ali, F.M. Al-Hemaid, Ionics 21, 547 (2015)

    Article  CAS  Google Scholar 

  40. S. Cheemalapati, B. Devadas, S.-M. Chen, J. Colloid Interface Sci. 418, 132 (2014)

    Article  CAS  Google Scholar 

  41. B.R. Ferraz, F.R. Leite, A.R. Malagutti, J. Solid State Electrochem. 20, 2509 (2016)

    Article  CAS  Google Scholar 

  42. P.K. Kalambate, C.R. Rawool, A.K. Srivastava, Sens. Actuators B Chem. 237, 196 (2016)

    Article  CAS  Google Scholar 

  43. B.R.L. Ferraz, F.R.F. Leite, A.R. Malagutti, Talanta 154, 197 (2016)

    Article  CAS  Google Scholar 

Download references

Acknowledgement

This work was supported by the Durban University of Technology, Durban, South Africa.

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Authors and Affiliations

  1. Department of Chemistry, Durban University of Technology, Durban, 4000, South Africa

    Rajasekhar Chokkareddy, Niranjan Thondavada, Bakusele Kabane & Gan G. Redhi

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  1. Rajasekhar Chokkareddy
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  2. Niranjan Thondavada
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  3. Bakusele Kabane
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  4. Gan G. Redhi
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Correspondence to Rajasekhar Chokkareddy.

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Chokkareddy, R., Thondavada, N., Kabane, B. et al. A novel ionic liquid based electrochemical sensor for detection of pyrazinamide. J IRAN CHEM SOC 18, 621–629 (2021). https://doi.org/10.1007/s13738-020-02047-1

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  • DOI: https://doi.org/10.1007/s13738-020-02047-1

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