Abstract
Extraovarian adult granulosa cell tumor is a very uncommon neoplasm, which probably arises from the ectopic gonadal tissue along the embryonic root of the genital ridge. We report a new and rare case of an extraovarian adult granulosa cell tumor occurring in a 66-year-old woman who was presented with severe abdominal pain focused on the left iliac fossa. The immunohistopathology confirmed the diagnosis of a paratubal adult granulosa cell tumor. This paper illustrates the histogenetic origin of granulosa cell tumor, its clinicopathological and immunohistochemical features.
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Abbreviations
- AGCT:
-
Granulosa cell tumor
- GCT:
-
Granulosa cell tumor
- CT:
-
Computerized tomography scan
- IHC:
-
Immunohistochemistry
- EMA:
-
Epithelial membrane antigen
- CEA:
-
Carcinoembryonic antigen
References
Schumer ST, Cannistra SA (2003) Granulosa cell tumor of the ovary. J Clin Oncol 21(6):1180–1189. https://doi.org/10.1200/JCO.2003.10.019
Al-Shraideh Y, Mahfooz AB, Aslam M, Alhazmi A, Alshakweer W (2012) Primary retroperitoneal granulosa cell tumor. UroToday Int J. 5(6):art 61. https://doi.org/10.3834/uij.1944-5784.2012.12.11
Paul PC, Chakraborty J, Chakrabarti S, Chattopadhyay B (2009) Extraovarian granulose cell tumor. Indian J Pathol Microbiol 52:231–233
Sharma P, Singh V, Mishra N, Gopinath M, Gupta P (2022) Primary retroperitoneal extraovarian granulosa cell tumor. Autops Case Rep 12:e2021355. https://doi.org/10.4322/acr.2021.355
Neeli SI, Malur PR (2010) Primary retroperitoneal extraovarian granulosa cell tumor: a case report. Uro Today Int J 3:1
Geetha P, Nair MK (2010) Granulosa cell tumours of the ovary. Aust N Z J Obstet Gynaecol 50:216–220
Rifki Jai S, Robleh Hassan F, Boussabir A, Boufettal R, Chehab F (2016) Extraovarian granulosa cell tumor: a case report. Pan Afr Med J 23:86. https://doi.org/10.11604/pamj.2016.23.86.8048
Kim SH, Park HJ, Linton JA, Shin DH, Yang WI, Chung WY et al (2001) Extraovarian granulosa cell tumor. Yonsei Med J 42:360–363
Motta PM, Makabe S (1986) Germ cells in the ovarian surface during fetal development in humans. J Submicrosc Cytol 18:271–290
Charles Z, Brenda WN (2006) The ovary and fallopian tube. In: Silverberg SG (ed) Silverberg’s principles and practice of surgical pathology and cyopathology. Churchill Livingstone, Mississippi, pp 2015–2017
Koukourakis GV, Kouloulias VE, Koukourakis MJ, Zacharias GA, Papadimitriou C, Mystakidou K, Pistevou- Gompaki K, Kouvaris J, Gouliamos A (2008) Granulosa cell tumor of the ovary: tumor review. Integr Cancer Ther 7:204–215
Pranita M, Swagata D (2016) A rare case of extraovarian granulosa cell tumor presenting as a retroperitoneal mass. Ann Pathol Lab Med [S.l.] 3(3):C153-155
Vihko KK, Blδuer M, Puistola U, Tuohimaa P (2003) Activin B in patients with granulosa cell tumours: serum levels in comparison to inhibin. Acta Obstet Gynecol Scand 82:570–574
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We gratefully acknowledge the patient for allowing us to publish this case.
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OK was responsible for the original manuscript writing. AS was involved in the revision and correction of the manuscript. All authors read and approved the final manuscript.
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Oqbani, K., Mouhoub, M. & Abbaoui, S. Unusual presentation of adult granulosa cell tumor. A case report and review of the literature. Int Canc Conf J 12, 190–194 (2023). https://doi.org/10.1007/s13691-023-00603-z
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DOI: https://doi.org/10.1007/s13691-023-00603-z