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Unusual presentation of adult granulosa cell tumor. A case report and review of the literature

  • Case Report - Pathology
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Abstract

Extraovarian adult granulosa cell tumor is a very uncommon neoplasm, which probably arises from the ectopic gonadal tissue along the embryonic root of the genital ridge. We report a new and rare case of an extraovarian adult granulosa cell tumor occurring in a 66-year-old woman who was presented with severe abdominal pain focused on the left iliac fossa. The immunohistopathology confirmed the diagnosis of a paratubal adult granulosa cell tumor. This paper illustrates the histogenetic origin of granulosa cell tumor, its clinicopathological and immunohistochemical features.

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Abbreviations

AGCT:

Granulosa cell tumor

GCT:

Granulosa cell tumor

CT:

Computerized tomography scan

IHC:

Immunohistochemistry

EMA:

Epithelial membrane antigen

CEA:

Carcinoembryonic antigen

References

  1. Schumer ST, Cannistra SA (2003) Granulosa cell tumor of the ovary. J Clin Oncol 21(6):1180–1189. https://doi.org/10.1200/JCO.2003.10.019

    Article  PubMed  Google Scholar 

  2. Al-Shraideh Y, Mahfooz AB, Aslam M, Alhazmi A, Alshakweer W (2012) Primary retroperitoneal granulosa cell tumor. UroToday Int J. 5(6):art 61. https://doi.org/10.3834/uij.1944-5784.2012.12.11

    Article  Google Scholar 

  3. Paul PC, Chakraborty J, Chakrabarti S, Chattopadhyay B (2009) Extraovarian granulose cell tumor. Indian J Pathol Microbiol 52:231–233

    Article  PubMed  Google Scholar 

  4. Sharma P, Singh V, Mishra N, Gopinath M, Gupta P (2022) Primary retroperitoneal extraovarian granulosa cell tumor. Autops Case Rep 12:e2021355. https://doi.org/10.4322/acr.2021.355

    Article  PubMed  PubMed Central  Google Scholar 

  5. Neeli SI, Malur PR (2010) Primary retroperitoneal extraovarian granulosa cell tumor: a case report. Uro Today Int J 3:1

    Google Scholar 

  6. Geetha P, Nair MK (2010) Granulosa cell tumours of the ovary. Aust N Z J Obstet Gynaecol 50:216–220

    Article  PubMed  Google Scholar 

  7. Rifki Jai S, Robleh Hassan F, Boussabir A, Boufettal R, Chehab F (2016) Extraovarian granulosa cell tumor: a case report. Pan Afr Med J 23:86. https://doi.org/10.11604/pamj.2016.23.86.8048

    Article  Google Scholar 

  8. Kim SH, Park HJ, Linton JA, Shin DH, Yang WI, Chung WY et al (2001) Extraovarian granulosa cell tumor. Yonsei Med J 42:360–363

    Article  CAS  PubMed  Google Scholar 

  9. Motta PM, Makabe S (1986) Germ cells in the ovarian surface during fetal development in humans. J Submicrosc Cytol 18:271–290

    CAS  PubMed  Google Scholar 

  10. Charles Z, Brenda WN (2006) The ovary and fallopian tube. In: Silverberg SG (ed) Silverberg’s principles and practice of surgical pathology and cyopathology. Churchill Livingstone, Mississippi, pp 2015–2017

    Google Scholar 

  11. Koukourakis GV, Kouloulias VE, Koukourakis MJ, Zacharias GA, Papadimitriou C, Mystakidou K, Pistevou- Gompaki K, Kouvaris J, Gouliamos A (2008) Granulosa cell tumor of the ovary: tumor review. Integr Cancer Ther 7:204–215

    Article  PubMed  Google Scholar 

  12. Pranita M, Swagata D (2016) A rare case of extraovarian granulosa cell tumor presenting as a retroperitoneal mass. Ann Pathol Lab Med [S.l.] 3(3):C153-155

    Google Scholar 

  13. Vihko KK, Blδuer M, Puistola U, Tuohimaa P (2003) Activin B in patients with granulosa cell tumours: serum levels in comparison to inhibin. Acta Obstet Gynecol Scand 82:570–574

    Article  PubMed  Google Scholar 

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Acknowledgements

We gratefully acknowledge the patient for allowing us to publish this case.

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OK was responsible for the original manuscript writing. AS was involved in the revision and correction of the manuscript. All authors read and approved the final manuscript.

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Correspondence to K. Oqbani.

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The authors declare that they have no competing interests.

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Written informed consent was obtained from the patient for publication of this case report and any accompanying images.

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Oqbani, K., Mouhoub, M. & Abbaoui, S. Unusual presentation of adult granulosa cell tumor. A case report and review of the literature. Int Canc Conf J 12, 190–194 (2023). https://doi.org/10.1007/s13691-023-00603-z

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  • DOI: https://doi.org/10.1007/s13691-023-00603-z

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