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Viral Infections and Obesity

  • ETIOLOGY OF OBESITY (T GILL, SECTION EDITOR)
  • Published:
Current Obesity Reports Aims and scope Submit manuscript

Abstract

Purpose of review

Obesity is a multifactorial disease that is now endemic throughout most of the world. Although addressing proximate causes of obesity (excess energy intake and reduced energy expenditure) have been longstanding global health priorities, the problem has continued to worsen at the global level.

Recent findings

Numerous microbial agents cause obesity in various experimental models—a phenomena known as infectobesity. Several of the same agents alter metabolic function in human cells and are associated with human obesity or metabolic dysfunction in humans. We address the evidence for a role in the genesis of obesity for viral agents in five broad categories: adenoviridae, herpesviridae, phages, transmissible spongiform encephalopathies (slow virus), and other encephalitides and hepatitides. Despite the importance of this topic area, there are many persistent knowledge gaps that need to be resolved.

Summary

We discuss factors motivating further research and recommend that future infectobesity investigation should be more comprehensive, leveraged, interventional, and patient-centered.

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Acknowledgements

The authors thank Dr. Timothy Gill and Dr. Eric Olsen for their helpful feedback on the final manuscript. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Air Force, the Department of Defense, or the US Government. Distribution A: 88PA Case no. 2016-4417, 9 Sept. 2016.

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Authors and Affiliations

  1. United States Air Force School of Aerospace Medicine, Epidemiology Consult Service Division, 2510 Fifth Street, Building 840, Wright-Patterson AFB, OH, 45433, USA

    Jameson D. Voss

  2. Department of Nutritional Sciences, Texas Tech University, Box 41270, Lubbock, TX, 79409-1240, USA

    Nikhil V. Dhurandhar

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  1. Jameson D. Voss
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  2. Nikhil V. Dhurandhar
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Correspondence to Nikhil V. Dhurandhar.

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Jameson D. Voss declares that he has no conflict of interest.

Nikhil V. Dhurandhar has several patents in viral obesity and adenovirus 36 including uses for E1A, E4-ORF1 gene and protein, and AKT1 inhibitor, and has ongoing grant support from Vital Health Interventions for determining anti-diabetic properties of E4-ORF1 protein.

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This article does not report any original research with human or animal subjects performed by any of the authors.

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No funding was obtained for this work.

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This article is part of the Topical Collection on Etiology of Obesity

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Voss, J.D., Dhurandhar, N.V. Viral Infections and Obesity. Curr Obes Rep 6, 28–37 (2017). https://doi.org/10.1007/s13679-017-0251-1

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