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Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry

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Abstract

The multi-disciplinary field of microfluidics has the potential to provide solutions to a diverse set of problems. It offers the advantages of high-throughput, continuous, rapid and expeditious analysis requiring minute quantities of sample. However, even as this field has yielded many mass-manufacturable and cost-efficient point-of-care devices, its direct and practical applications into the field of disease diagnostics still remain limited and largely overlooked by the industry. This review focuses on the phenomenon of hydrodynamic focusing and its potential to materialize solutions for appropriate diagnosis and prognosis. The study aims to look beyond its intended cytometric applications and focus on unambiguous disease detection, monitoring, drug delivery, studies conducted on DNA and highlight the instances in the scientific literature that have proposed such approach.

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Acknowledgements

The authors would like to acknowledge the aid provided by the Birla Institute of Technology and Science, Pilani, KK Birla Goa Campus via ‘Research Initiation Grant’.

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  1. Department of Mechanical Engineering, Birla Institute of Technology and Science, Pilani, K. K. Birla Goa Campus, Zuarinagar, Sancoale, Goa, 403726, India

    Aakash Rajawat & Siddhartha Tripathi

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Manuscript: AR, Writing: AR, Reviewing and editing the final manuscript: ST, Writing the original draft: AR, Figure preparation: AR, Resources: ST.

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Correspondence to Siddhartha Tripathi.

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Rajawat, A., Tripathi, S. Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry. Biomed. Eng. Lett. 10, 241–257 (2020). https://doi.org/10.1007/s13534-019-00144-6

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