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Association of the rs7903146 variant (IVS3C> T) of TCF7L2 with the prevalence of the metabolic syndrome and its components in population from Ahvaz cohort study: a case-control study in Iran

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Abstract

Background

The metabolic syndrome consists of a combination of metabolic abnormalities and genetic predisposition that both contribute significantly to its development. Numerous studies have established a strong association between single nucleotide polymorphisms (SNPs) of the rs7903146 variant in the TCF7L2 gene and the metabolic syndrome (MetS) as well as type 2 diabetes.

Objective

The aim of this study was to assess the impact of rs7903146 on MetS and its components.

Methods

For this cross-sectional study, 325 individuals aged 25 to 86 who were selected from the baseline data of the Ahvaz cohort study were examined. Body mass index, blood pressure, fasting blood glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were measured following standard protocols. MetS subjects were identified based on the National Cholesterol Education Program guidelines. Genotyping was conducted using the PCR-RFLP method.

Results

Our findings revealed that individuals with the CT genotype of rs7903146 had an increased risk of MetS (OR 2.24; 95% CI, 1.26–3.98; p < 0.006). This genotype was also found to be associated with a higher risk of hypertension and low HDL cholesterol (p < 0.05). Moreover, plasma triglyceride levels were slightly higher in individuals with TT and CT genotypes, although not significantly so (p = 0.06).

Conclusion

In conclusion, the CT genotype of the TCF7L2 rs7903146 polymorphism exhibited higher odds for MetS. While lifestyle factors and other genes are also implicated in MetS, our findings suggest that studying TCF7L2 polymorphisms in high-risk groups could contribute to the development of genotype-specific prevention or treatment strategies. However, further research is required to validate these results.

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Data Availability

Data will be made available on request.

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Funding

This study was supported by grants from Ahvaz Jundishapur University of Medical Sciences (IR.AJUMS.REC.1397.137) and experimentally done in Department of Laboratory Sciences, Iran.

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Authors and Affiliations

  1. Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Mojdeh Rahimi & Hajieh Shahbazian

  2. Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Negar dinarvand & Narges Mohammadtaghvaei

  3. Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Maryam Tahmasebi Birgani

  4. Alimentary Tract Research Center, Department of Biostatistics & Epidemiology School of Public Health, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

    Bahman cheraghian

Authors
  1. Mojdeh Rahimi
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  2. Negar dinarvand
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  3. Hajieh Shahbazian
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  4. Maryam Tahmasebi Birgani
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  5. Bahman cheraghian
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  6. Narges Mohammadtaghvaei
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Contributions

NM conceived and supervised the study; MR and HS performed experiments; MTB and BC analyzed data; ND and MR wrote the paper. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Narges Mohammadtaghvaei.

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Conflict of interest

The authors declare no competing interests.

Ethical clearance, consent of participant

The study protocol was approved by the Research Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (HLRC-9505), and informed consent was obtained from all participants.

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Rahimi, M., dinarvand, N., Shahbazian, H. et al. Association of the rs7903146 variant (IVS3C> T) of TCF7L2 with the prevalence of the metabolic syndrome and its components in population from Ahvaz cohort study: a case-control study in Iran. Int J Diabetes Dev Ctries (2023). https://doi.org/10.1007/s13410-023-01286-1

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