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Targeting inflammation using celecoxib with glimepiride in the treatment of obese type 2 diabetic Egyptian patients

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International Journal of Diabetes in Developing Countries Aims and scope Submit manuscript

Abstract

Obesity, insulin resistance (IR), inflammation, and progressive decline in pancreatic β cell function are major features of type 2 diabetes mellitus (T2DM). We aimed to investigate the effect of co-administration of celecoxib (CE) with glimepiride (GL) in the treatment of obese T2DM patients. Body Mass Index (BMI), serum glucose, C-peptide, lipid profile, adiponectin, tumor necrosis factor-α (TNF-α), visfatin, and leptin levels were determined in 40 obese T2DM patients before and after treatment with GL alone or in combination with a selective cyclooxygenase-2 (COX-2) inhibitor CE for 3 months. Homeostasis model assessment of insulin resistance (HOMA2-IR) and atherogenic index (AI) was calculated. Increased levels of serum glucose, C-peptide, total cholesterol (TCH), low-density lipoprotein (LDL-C), triglycerides (TGs), visfatin, TNF-α, leptin, AI, and HOMA2-IR shown in obese diabetic patients were significantly decreased after co-treatment with GL plus CE compared to patients who received GL alone. On the other hand, adiponectin levels showed a significant increase after treatment. The obtained results demonstrate that targeting inflammation using celecoxib with glimepiride improves insulin resistance, glycemia, and inflammatory process in obese type 2 diabetics.

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Abbreviations

BG:

Blood glucose

COPD:

Chronic obstructive pulmonary disease

COX-2:

Cyclooxygenase-2

CVD:

Cardiovascular disease

ELISA:

Enzyme-linked immunosorbent assay

GIT:

Gastrointestinal tract

HDL-C:

High-density lipoprotein

HOMA2-IR:

Homeostasis model assessment of insulin resistance

HOMA2-β:

Homeostasis model assessment of beta cell functionality

LDL-C:

Low-density lipoprotein

T2DM:

Type 2 diabetes mellitus

TCH:

Total cholesterol

TGs:

Triglycerides

TNF-α:

Tumor necrosis factor alpha

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Acknowledgments

The author gratefully acknowledges Prof. Dr. Osama M. Ibrahim, Chairman of the Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, for his support and helpful assistance in instruments supply and lab availability.

Conflict of interest

The authors declared that there are no conflicts of interest.

Author’s contribution

Hoda El-Bahrawy did the conception and design of the study and final approval of the version to be published. Sahar Hegazy followed up the patients and drafted the article or revised it critically for important intellectual content. Wael Farrag took the detailed history from patients, examined the patients clinically, and analyzed and interpreted the data. Rehab Werida followed up the patients and collected samples from them; performed anthropometric evaluations and biochemical assay for selected parameters; analyzed obtained data; and drafted the article or revised it critically for important intellectual content, and gave final approval of the version to be published.

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Authors and Affiliations

  1. Biochemistry Department, Faculty of Pharmacy, Tanta University, El-Gharbia, Egypt

    Hoda El-Bahrawy

  2. Clinical Pharmacy Department, Faculty of Pharmacy, Tanta University, El-Gharbia, Egypt

    Sahar Hegazy

  3. Internal Medicine Department, Faculty of Medicine, Tanta University, El-Gharbia, Egypt

    Wael Farrag

  4. Drug Information Center, Faculty of Pharmacy, Tanta University, El-Gharbia, 31527, Egypt

    Rehab Werida

Authors
  1. Hoda El-Bahrawy
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  2. Sahar Hegazy
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  3. Wael Farrag
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  4. Rehab Werida
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Corresponding author

Correspondence to Rehab Werida.

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El-Bahrawy, H., Hegazy, S., Farrag, W. et al. Targeting inflammation using celecoxib with glimepiride in the treatment of obese type 2 diabetic Egyptian patients. Int J Diabetes Dev Ctries 37, 97–102 (2017). https://doi.org/10.1007/s13410-015-0355-7

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  • DOI: https://doi.org/10.1007/s13410-015-0355-7

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