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Eco-friendly phytofabrication of silver nanoparticles using aqueous extract of Aristolochia bracteolata Lam: its antioxidant potential, antibacterial activities against clinical pathogens and malarial larvicidal effects

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Abstract

The silver nitrate was reduced into silver nanoparticles by using the Aristolochia bracteolata plant aqueous extract. The green-synthesized nanoparticles were characterized through UV–Vis spectrophotometry, FTIR, EDAX, XRD, and TEM analysis. Results of TEM analysis clearly show that synthesized AgNP size range is 6 to 20 nm. The average particle size and zeta potential value was determined and found to be 16.7 nm and − 24.2 mV, respectively. The silver nanoparticles showed remarkable antibacterial, DPPH, ABTS, and FRAP activity. Silver nanoparticles exhibited strong antiradical effectiveness with minimal concentration. AgNPs had a dose-dependent effect on Anopheles stephensi larvae, with LC50 values of 21.3, 45.5, 12.7, and 7.9 and LC90 values of 32.4, 65.3, 20.1, and 15.4 µg/mL, respectively. The highest pupal activity was observed at 2.0 µg/mL, with the LC50 being 4.0 and the LC90 being 9.1 µg/mL, respectively. The biotoxicity assay of A. salina shows 6.33–48.33% mortality, which was exhibited by the A. bracteolata-bioconverted AgNPs. The LC50 and LC90 values were 610.381 and 6214 µg/mL. No behavioral variations were observed. The present study provides the first scientific information on the antibacterial, larvicidal, and pupicidal properties of AgNPs produced from a leaf extract of A. bracteolata.

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Data availability

During the present research entities, the datasets gathered and generated from the analysis after synthesis of AgNPs using A. bracteolata and the evaluated biological results are available from the corresponding author on reasonable request.

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Acknowledgements

We acknowledged the Department of Biotechnology, School of Biosciences, Periyar University, Salem, Tamil Nadu, India, for providing the infrastructural facility to carry out this research work. We thank the Department of Physics, Periyar University, Salem, for XRD and FTIR analyses of samples. Our special gratitude goes to the Indian Institute of Technology (IIT, Chennai), Tamil Nadu, for analyzing the sample (TEM and EDX). This research work was partially supported by Chiang Mai University.

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Authors and Affiliations

  1. Natural Drug Research Laboratory, Department of Biotechnology, School of Biosciences, Periyar University, Periyar Palkalai Nagar, Salem, 636 011, Tamil Nadu, India

    Ragavendran Chinnasamy

  2. Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 600 077, India

    Ragavendran Chinnasamy

  3. Interdisciplinary Institute of Indian System of Medicine (IIISM), Directorate of Research and Virtual Education, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Chennai, 603203, Tamil Nadu, India

    Kamaraj Chinnaperumal

  4. Department of Ocean Studies and Marine Biology, Pondicherry University, Port Blair Campus, Brookshabad, Port Blair, Andamans, 744112, India

    Tijo Cherian

  5. Department of Microbiology, Sona College of Arts and Science, Salem, 636005, Tamil Nadu, India

    Kayalvizhi Thamilchelvan

  6. Department of Research and Innovation, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, 602105, Tamil Nadu, India

    Balasubramani Govindasamy

  7. Carbon Capture Lab, Department of Chemical Engineering, SSN College of Engineering, Kalavakkam, Chennai, 603110, Tamil Nadu, India

    Cittrarasu Vetrivel

  8. Department of Anatomy, Saveetha Dental College and Hosppitals, Chennai, India

    Cittrarasu Vetrivel

  9. Department of Entomology and Plant Pathology, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand

    Vivekanandhan Perumal & Patcharin Krutmuang

  10. Institute of Environmental Sciences (CML), Leiden University, P.O. Box 9518, 2300 RA, Leiden, The Netherlands

    Peijnenburg Willie

  11. Center for Safety of Substances and Products, National Institute of Public Health and the Environment (RIVM), P.O. Box 1, Bilthoven, The Netherlands

    Peijnenburg Willie

  12. Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai, 50200, Thailand

    Patcharin Krutmuang

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  1. Ragavendran Chinnasamy
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Contributions

CR, GB, JR, and CK all contributed to the experiment’s overall design and planning, larval data processing, and result interpretation. CT, CV, and TK were used throughout the antibacterial activity, from pathogen collection through interpretation. CR and TJ conducted the toxicology testing on Brine Shrimp at its labs. In order to conduct the mosquito larvicidal toxicity test, CRI was used. The manuscript was written by CR, GB, SSN, PV, and CK. All authors, with the exception of WJGMP, PK, and CR, have reviewed and approved the final manuscript for publication.

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Correspondence to Ragavendran Chinnasamy or Patcharin Krutmuang.

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Chinnasamy, R., Chinnaperumal, K., Cherian, T. et al. Eco-friendly phytofabrication of silver nanoparticles using aqueous extract of Aristolochia bracteolata Lam: its antioxidant potential, antibacterial activities against clinical pathogens and malarial larvicidal effects. Biomass Conv. Bioref. (2023). https://doi.org/10.1007/s13399-023-03750-8

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