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In vitro Antitumor, Antibacterial, and Antifungal Activities of Phenylthio-Ethyl Benzoate Derivatives

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Abstract

In this study, four compounds of 2-(phenylthio)-ethyl benzoate derivatives were synthesized and evaluated for their antitumor, antibacterial, and antifungal activities. These compounds were characterized and evaluated for their cytotoxic activity in MCF-7-human carcinoma cells that showed a significant decrease for compounds 2a–2d in the average of G2-M phase as 8.13 ± 1.4, 10.66 ± 1.5, 14 ± 2.2, and 3.66 ± 0.8%, respectively, compared with untreated cells (21 ± 2%; p < 0.05). The data suggest that 2d compound could have an anticancer potential in the G2-M phase arrest of MCF-7 cells ultimately leading to necrosis. The compounds were tested for their antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Proteus vulgaris, Enterococcus faecium, Pseudomonas aeruginosa, MRSA, and Candida albicans and showed antimicrobial potential with MIC value average (3.125–6.25 mg/ml), compared with ampicillin (0.001–3.125 mg/ml). When the MIC of the four compounds was compared with known references, we found that the 2a compound has the same MIC as fluconazole (1.56 mg/ml), inhibitor of Candida growth. Moreover, 2a, 2b,, and 2d have the same MIC as ampicillin (3.125 mg/ml) for the inhibition of S. aureus.

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Acknowledgements

The authors would like to acknowledge the Faculty of Graduate Studies, Pharmaceutical Sciences Program, at An-Najah National University for facilitating the accomplishment of the current study.

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Authors and Affiliations

  1. Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, P.O. Box 7, 00970, Nablus, Palestine

    Nidal Jaradat, Ahmad Khasati, Maram Hawi & Mohammed Hawash

  2. Department of Biomedical Sciences, Physiology, Pharmacology and Toxicology Division, Faculty of Medicine and Health Sciences, An-Najah National University, 00970, Nablus, Palestine

    Mohammad Qadi & Johnny Amer

Authors
  1. Nidal Jaradat
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  2. Ahmad Khasati
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  3. Maram Hawi
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  4. Mohammad Qadi
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  5. Johnny Amer
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  6. Mohammed Hawash
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The current research was done by the authors.

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Correspondence to Nidal Jaradat.

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Jaradat, N., Khasati, A., Hawi, M. et al. In vitro Antitumor, Antibacterial, and Antifungal Activities of Phenylthio-Ethyl Benzoate Derivatives. Arab J Sci Eng 46, 5339–5344 (2021). https://doi.org/10.1007/s13369-020-05114-0

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  • DOI: https://doi.org/10.1007/s13369-020-05114-0

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