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Exponential Stability of Stochastic Genetic Regulatory Networks with Interval Uncertainties and Multiple Delays

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Abstract

In this paper, the delay-dependent exponential stability analysis problem for a class of genetic regulatory networks (GRNs) with multiple time-varying delays and interval parameter uncertainties is studied. By employing a new Lyapunov–Krasovskii functional and employing some free-weighting matrices, we derive sufficient delay-dependent conditions ensuring the exponential stability of interval GRNs with multiple time-varying delays and stochastic perturbations in the form of linear matrix inequalities. Finally, three numerical examples are used to demonstrate and verify the advantages of the main results.

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References

  1. Becskei A., Serrano L.: Engineering stability in gene networks by autoregulation. Nature 405, 590–593 (2000)

    Article  Google Scholar 

  2. Zhang W., Tang Y., Fang J., Wu X.: Stochastic stability of genetic regulatory networks with a finite set delay characterization. Chaos 22, 023106 (2012)

    Article  Google Scholar 

  3. Zhang W., Fang J., Tang Y.: Robust stability for genetic regulatory networks with linear fractional uncertainties. Commun. Nonlinear Sci. Numer Simul. 17, 1753–1765 (2012)

    Article  MATH  MathSciNet  Google Scholar 

  4. Elowitz M.B., Leibler S.: A synthetic oscillatory network of transcriptional regulators. Nature 403, 335–338 (2000)

    Article  Google Scholar 

  5. Gardner T.S., Cantor C.R., Collins J.J.: Construction of a genetic toggle switch in Escherichia coli. Nature 403, 339–342 (2000)

    Article  Google Scholar 

  6. Zhang W., Fang J., Tang Y.: Stochastic stability of Markovian jumping genetic regulatory networks with mixed time delays. Appl. Math. Computat. 217, 7210–7225 (2011)

    Article  MATH  MathSciNet  Google Scholar 

  7. Friedman N., Linial M., Nachman I. et al.: Using Bayesian networks to analyze expression data. J. Comput. Biol. 7, 601–620 (2000)

    Article  Google Scholar 

  8. Hartemink A.J., Gifford D.K., Jaakkola T.S. et al.: Bayesian methods for elucidating genetic regulatory networks. IEEE Intell. Syst. 17, 37–43 (2002)

    Google Scholar 

  9. Huang S.: Gene expression profiling genetic regulatory networks and cellular states: an integrating concept for tumorigenesis and drug discovery. J. Mol. Med. 77, 469–480 (1999)

    Article  Google Scholar 

  10. Kauffman S.A.: Metabolic stability and epigenesist in randomly constructed genetic nets. J. Theor. Biol. 22, 437–467 (1969)

    Article  MathSciNet  Google Scholar 

  11. Chen L., Aihara K.: Stability of genetic regulatory networks with time delay. IEEE Trans. CAS-I 49, 602–608 (2002)

    Article  MathSciNet  Google Scholar 

  12. Zhang W., Fang J., Tang Y.: New robust stability analysis for genetic regulatory networks with random discrete delays and distributed delays. Neurocomputing 74, 2344–2360 (2011)

    Article  Google Scholar 

  13. Tang Y., Wang Z., Fang J.: Parameters identification of unknown delayed genetic regulatory networks by a switching particle swarm optimization algorithm. Expert Syst. Appl. 38, 2523–2535 (2011)

    Article  Google Scholar 

  14. Li C., Chen L., Aihara K.: Stability of genetic networks with sum regulatory logic:Lur’s system and LMI approach. IEEE Trans. Circuits Syst. I 53, 2451–2458 (2006)

    Article  MathSciNet  Google Scholar 

  15. Cao J., Ren F.: Exponential stability of discrete-time genetic regulatory networks with delays. IEEE Trans. Neural Netw. 19, 520–523 (2008)

    Article  Google Scholar 

  16. He W., Cao J.: Robust stability of genetic regulatory networks with distrituted delay. Cogn. Neurodyn. 2, 355–361 (2008)

    Article  Google Scholar 

  17. Ren F., Cao J.: Asymptotic and robust stability of genetic regulatory networks with time-varying delays. Neurocomputing 71, 834–842 (2008)

    Article  Google Scholar 

  18. Wang Z., Gao H., Cao J., Liu X.: On delayed genetic regulatory networks with polytopic uncertainties: robust stability analysis. IEEE Trans. Nanbiosci. 7, 154–163 (2008)

    Article  Google Scholar 

  19. Wu, F.: Stability analysis of genetic regulatory networks with multiple time delays. In: Proceedings of the 29th Annual International Conference of the IEEE EMBS Cite Internationale, Lyon, France August 23–26 (2007)

  20. Wu F.: Delay-independent stability of genetic regulatory netowkrs with time delays. Adv. Complex Syst. 12, 3–19 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  21. Wang Y., Shen J., Niu B. et al.: Robustness of interval gene networks with multiple time-varying delays and noise. Neurocomputing 72, 3303–3310 (2009)

    Article  Google Scholar 

  22. Pan W., Wang Z., Gao H. et al.: On multistability of delayed genetic regulatory networks with multivariable regulation functions. Math. Biosci. 228, 100–109 (2010)

    Article  MATH  MathSciNet  Google Scholar 

  23. Wang Z., Lam J., Wei G. et al.: Filtering for nonlinear genetic regulatory networks with stochastic disturbances. IEEE Trans. Autom. Control 53, 2448–2457 (2008)

    Article  MathSciNet  Google Scholar 

  24. Tian T., Burragea K., Burragea P.M. et al.: Stochastic delay differential equations for genetic regulatory networks. J. Comput. Appl. 205, 696–707 (2007)

    Article  MATH  Google Scholar 

  25. Wang G., Cao J.: Robust exponential stability analysis for stochastic genetic network with uncertain parameters. Commun. Nonlinear Sic. Number. Simul. 14, 3369–3378 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  26. Sun Y., Feng G., Cao J.: Stochastic stability of Markovian switching genetic regulatory networks. Phys. Lett. A 373, 1646–1652 (2009)

    Article  MATH  MathSciNet  Google Scholar 

  27. Balasubramaniam P., Rakkiyappan R., Krishnasamy R.: Stochastic stability of Markovian jumping uncertain stochastic genetic regulatory network with interval time-varying delays. Math. Biosci. 226, 97–108 (2010)

    Article  MATH  MathSciNet  Google Scholar 

  28. Li P., Lam J., Shu Z.: On the transient and steady-state estimates of interval genetic regulatory networks. IEEE Trans. Syst. Man Cybern. Part B: Cybern. 40, 336–349 (2010)

    Article  Google Scholar 

  29. Kao, Y.; Wang, C.; Zhang, L.: Delay-dependent robust exponential stability of impulsive Markovian jumping reaction–diffusion Cohen–Grossberg neural networks, Neural Process. Lett. doi:10.1007/s11063-012-9269-2

  30. Yang, G.; Kao, Y.; Wang, C.: Exponential stability and periodicity of fuzzy delayed reaction–diffusion cellular neural networks with impulsive effect. Abstr. Appl. Anal. (2013), 645262, 9 p

  31. Yang, G.; Kao, Y.; Li, W.; Sun, X.: Exponential stability of impulsive stochastic fuzzy cellular neural networks with mixed delays and reactionCdiffusion terms. Neural Comput. Appl. doi:10.1007/s00521-012-1040-0

  32. Wang C., Kao Y., Yang G.: Exponential stability of impulsive stochastic fuzzy reaction–diffusion Cohen–Grossberg neural networks with mixed delays. Neurocomputing 89, 55–63 (2012)

    Article  Google Scholar 

  33. Kao Y., Wang C.: Global stability analysis for stochastic coupled reactionCdiffusion systems on networks. Nonlinear Anal. Real World Appl. 14, 1457–1465 (2013)

    Article  MATH  MathSciNet  Google Scholar 

  34. Zhang W., Tang Y., Fang J., Wu X.: Stability of delayed neural networks with time-varying impulses. Neural Netw. 36, 59–63 (2012)

    Article  MATH  Google Scholar 

  35. Baldi P., Atiya A.F.: How delays affect neural dynamics and learning. IEEE Trans. Neural Netw. 5, 612–621 (1994)

    Article  Google Scholar 

  36. Gu, K.: An integral inequality in the stability problem of time-delay systems. In: 39th IEEE Conference on Dscision and Control, Sydney, Australia, pp. 2805–2810 (Dec 2000)

  37. Boyd, S.; Ghaoui, L.E.; Feron E.; et al.: Linear Matrix Inequalities in System and Control Theory. SIAM, Philadelphia (1994)

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Li, Z., Chen, K. Exponential Stability of Stochastic Genetic Regulatory Networks with Interval Uncertainties and Multiple Delays. Arab J Sci Eng 39, 6507–6520 (2014). https://doi.org/10.1007/s13369-014-1206-4

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  • DOI: https://doi.org/10.1007/s13369-014-1206-4

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