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Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis

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Abstract

Psoriasis, an autoimmune inflammatory skin disorder, is one of the commonest immune-mediated disease conditions affecting individuals globally. At the moment, the conventional methods applied against psoriasis treatment have various drawbacks involving limited efficacy, skin irritation, immunosuppression, etc. Therefore, it is important for scientists to find a more potent and alternative drug approach towards psoriasis therapeutics. Natural medicine still remains an important source for new drug discovery due to its therapeutical significance in various drug administration routes. However, the traditional formulation of topical therapies for psoriasis is limited in efficacy, which limits the use of natural medicine. Based on the aforementioned limitations, the use of nanocarriers in preparation of these topical herbal products could be tremendously beneficial in enhancing the efficacy of topical medications. Growing pieces of evidence have proposed that the utilization of nanocarriers in transdermal preparation as a prospective technique, with regards to better potency, directs drug absorption to site of action, and minimum toxicity effect respectively. In the course of this review, we emphasized the pathological mechanism of psoriasis, natural medicine formula, active components of natural medicine, and nanopreparations used in the treatment of psoriasis.

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Funding

This work was financially supported by a grant (81803862) from the National Natural Science Foundation of China, Tianjin Municipal Education Commission research project (2017KJ131).

Author information

Authors and Affiliations

  1. State Key Laboratory of Component Natural Medicine, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin, 301617, China

    Zhiyue Zhao, Tao Liu, Shan Zhu, Jiaxin Pi, Pan Guo, Dongli Qi, Zhidong Liu & Nan Li

  2. Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique, Ministry of Education, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China

    Zhiyue Zhao, Jiaxin Pi, Pan Guo, Dongli Qi, Zhidong Liu & Nan Li

Authors
  1. Zhiyue Zhao
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  2. Tao Liu
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  3. Shan Zhu
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  4. Jiaxin Pi
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  5. Pan Guo
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  6. Dongli Qi
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  7. Zhidong Liu
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  8. Nan Li
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Contributions

Li Nan and Liu Zhidong had the idea for the article; Zhao Zhiyue, Liu Tao, and Zhu Shan performed the literature search and data analysis, and Pi Jiaxin, Guo Pan, Qi Dongli, and Li Nan drafted and critically revised the work.

Corresponding authors

Correspondence to Zhidong Liu or Nan Li.

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Zhao, Z., Liu, T., Zhu, S. et al. Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis. Drug Deliv. and Transl. Res. 12, 1326–1338 (2022). https://doi.org/10.1007/s13346-021-01031-3

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  • DOI: https://doi.org/10.1007/s13346-021-01031-3

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