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Pharmacokinetic study of rosuvastatin in males and females

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Abstract

Rosuvastatin is used to treat dyslipidemia and is metabolized by CYP2C9 that shows variable metabolic activity in males and females. Pharmacokinetics (PK) of drugs varies in males and females that may result in altered drug response and therapeutic efficacy. In current study, PK of rosuvastatin has been evaluated in males and females. A single oral dose (40 mg rosuvastatin), open-label and non-controlled PK study was arranged. A reversed phase HPLC method was applied for quantification of rosuvastatin in serum samples. PK parameters of rosuvastatin were compared in males and females by applying student t test at 95 % confidence interval. The C max, \([{\text{AUC}} ]_{0}^{8}\)and \([{\text{AUC}} ]_{0}^{\infty }\)of rosuvastatin was significantly higher (p < 0.05) in females compared with males. The Vd/F of rosuvastatin was insignificantly higher (p > 0.05) in males compared with females while CL/F was significantly (p < 0.05) faster in males when compared at 95 % confidence interval. Rosuvastatin plasma level was significantly high in females compared with males that may be a possible reason for higher incidence of cardiac myopathy and other side effects in females. The variation in PK of drugs in males and females may require dose adjustment for maximum therapeutic effectiveness and safety.

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Acknowledgments

We are thankful to University of Peshawar for providing facilities and technical support to conduct the study. We pay special thanks to Ferozsons private limited for providing us with standards of rosuvastatin.

Conflict of interest

No conflict of interest/financial exists.

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Authors and Affiliations

  1. University of Swabi, Swabi, Pakistan

    Yasar Shah, Lateef Ahmad & Abad Khan

  2. University of Peshawar, Peshawar, Pakistan

    Zafar Iqbal

  3. Kohat University of Science and Technology, Kohat, Pakistan

    Shabnam Nazir

Authors
  1. Shabnam Nazir
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  2. Zafar Iqbal
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  3. Yasar Shah
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  4. Lateef Ahmad
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  5. Abad Khan
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Correspondence to Shabnam Nazir.

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Nazir, S., Iqbal, Z., Shah, Y. et al. Pharmacokinetic study of rosuvastatin in males and females. Eur J Drug Metab Pharmacokinet 40, 313–318 (2015). https://doi.org/10.1007/s13318-014-0211-z

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  • DOI: https://doi.org/10.1007/s13318-014-0211-z

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