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Non-vaccine Pneumococcal Serotypes Among Children with Invasive Pneumococcal Disease

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Abstract

Objective

To report the percentage of non-vaccine pneumococcal serotypes and their antibiotic susceptibility pattern in children with invasive peumococcal disease.

Methods

Invasive pneumococcal isolates of children <5 years during January 2007 to December 2016 were serotyped by a co-agglutination reaction and sequential multiplex polymerase chain reaction.

Results

Among the total 170 S. pneumoniae invasive isolates, 54 (31.8%) and 44 (25.9 %) were the serotypes, which are not included in current 10-valent or 13-valent vaccines, respectively. Very low resistance was observed against penicillin (4.5%) and all isolates were susceptible to cefotaxime.

Conclusions

One-fourth to one-third of the S. pneumoniae serotypes in under-five children with invasive pneumococcal disease are not covered by existing pneumococcal vaccines in India.

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Authors and Affiliations

  1. Department of Clinical Microbiology, Christian Medical College and Hospital, Vellore, 632004, Tamil Nadu, India

    James John, Rosemol Varghese, Jones Lionell, Ayyanraj Neeravi & Balaji Veeraraghavan

Authors
  1. James John
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  2. Rosemol Varghese
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  3. Jones Lionell
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  4. Ayyanraj Neeravi
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  5. Balaji Veeraraghavan
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Corresponding author

Correspondence to Balaji Veeraraghavan.

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John, J., Varghese, R., Lionell, J. et al. Non-vaccine Pneumococcal Serotypes Among Children with Invasive Pneumococcal Disease. Indian Pediatr 55, 874–876 (2018). https://doi.org/10.1007/s13312-018-1398-x

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  • DOI: https://doi.org/10.1007/s13312-018-1398-x

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