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Auxiliary liver transplantation for acute liver failure

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Abstract

Background

Auxiliary partial orthotopic liver transplantation is a technique where part of diseased native liver is removed and replaced with healthy donor liver so that, the left behind native liver could later regenerate.

Case characteristics

2½-year-old girl with acute liver failure due to Hepatitis A. She underwent a successful auxiliary partial orthotopic liver transplantation.

Outcome

Successful native liver regeneration and immunosuppression withdrawal after two and half years of surgery.

Message

In selective cases of acute liver failure, auxiliary partial orthotopic liver transplantation could provide a chance for native liver regeneration and immunosuppression-free life.

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References

  1. Shanmugam NP, Dhawan A. Selection criteria for liver transplantation in paediatric acute liver failure: The saga continues. Pediatr Transplant. 2011;15:5–6.

    Article  PubMed  Google Scholar 

  2. Gubernatis G, Pichlmayr R, Kemnitz J, Gratz K. Auxiliary partial orthotopic liver transplantation (APOLT) for fulminant hepatic failure: First successful case report. World J Surg. 1991;15:660–5.

    Article  PubMed  CAS  Google Scholar 

  3. Kasahara M, Takada Y, Egawa H, Fujimoto Y, Ogura Y, Ogawa K, et al. Auxiliary partial orthotopic living donor liver transplantation: Kyoto University experience. Am J Transplant. 2005;5:558–65.

    Article  PubMed  Google Scholar 

  4. Faraj W, Dar F, Bartlett A, Melendez HV, Marangoni G, Mukherji D, et al. Auxiliary liver transplantation for acute liver failure in children. Ann Surg. 2010;251:351–6.

    Article  PubMed  Google Scholar 

  5. Quaglia A, Portmann BC, Knisely AS, Srinivasan P, Muiesan P, Wendon J, et al. Auxiliary transplantation for acute liver failure: Histopathological study of native liver regeneration. Liver Transpl. 2008;14:1437–48.

    Article  PubMed  Google Scholar 

  6. Li T, Qiu F, Qian ZR, Wan J, Qi XK, Wu BY. Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors. World J Gastroenterol. 2014;20:118–25.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Sarvida ME, O’Dorisio MS. Neuroendocrine tumors in children and young adults: Rare or not so rare. Endocrinol Metab Clin N Am. 2011;40:65–80.

    Article  Google Scholar 

  8. Howell DL, M. Sue O’Dorisio MS. Management of neuroendocrine tumors in children, adolescents, and young adults. J Pediatr Hematol Oncol. 2012;34:64–8.

    Article  Google Scholar 

  9. Anthony LB, Strosberg JR, Klimstra DS, Maples WJ, O’Dorisio TM, Warner RR, et al. The NANETS Consensus Guidelines for the Diagnosis and Management of Gastrointestinal Neuroendocrine Tumors (NETs): Welldifferentiated nets of the distal colon and rectum. Pancreas. 2010;39:767–74.

    Article  PubMed  Google Scholar 

  10. Cockburn AN, Morgan CJ, Genta RM. Neuroendocrine Proliferations of the Stomach: A pragmatic approach for the perplexed pathologist. Adv Anat Pathol. 2013;20:148–57.

    Article  PubMed  CAS  Google Scholar 

  11. Waldum HL, Hauso Ø, Fossmark R. The regulation of gastric acid secretion - clinical perspectives. Acta Physiol (Oxf). 2014;210:239–56.

    Article  CAS  Google Scholar 

  12. Yang R, Cheung MC, Zhuge Y, Armstrong C, Koniaris LG, Sola JE. Primary solid tumors of the colon and rectum in the pediatric patient: A review of 270 cases. J Surg Res. 2010;161:209–16.

    Article  PubMed  Google Scholar 

  13. Alexandraki KI, Nikolaou A, Thomas D, Syriou V, Korkolopoulou P, Sougioultzis S, et al. Are patients with autoimmune thyroid disease and autoimmune gastritis at risk of gastric neuroendocrine neoplasms type 1? Clin Endocrinol (Oxf). 2014;80:685–90.

    Article  CAS  Google Scholar 

  14. Johnson PR. Gastroenteropancreatic neuroendocrine (carcinoid) tumors in children. Semin Pediatr Surg. 2014;23:91–5.

    Article  PubMed  Google Scholar 

  15. Peracchi M, Gebbia C, Basilisco G, Quatrini M, Tarantino C, Vescarelli C, et al. Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enterochromaffin-like cel lesions and gastric carcinoids. Eur J Endocrinol. 2005;152:443–8.

    Article  PubMed  CAS  Google Scholar 

  16. Arjun KM. Indian agriculture - status, importance and role in Indian Economy. International Journal of Agriculture and Food Science Technology. 2013;4;343–6.

    Google Scholar 

  17. Akhtar W, Sengupta D, Chowdhury A. Impact of pesticides use in agricultural: their impact and hazards. Interdiscip Toxicol. 2009;2:1–12.

    Article  Google Scholar 

  18. Mukherjee I, Haldar D, Ghosh S, Moulik SP. Physicochemical Studies on an All-Purpose Pesticide Spray Adjuvant (APSA-80). J Dispers Sci Technol. 2009;10:1430–41.

    Article  Google Scholar 

  19. Amway.com, Michigan. Resource Centre documents. Available from http://www.amway.com/en/Resource CenterDocuments/APSA-80. Accessed April 1, 2015.

  20. Dutta AK, Seth A, Goyal PK, Aggarwal V, Mittal SK, Sharma R, et al. Poisoning in children: Indian scenario. Indian J Pediatr. 1998;65:365–70.

    Article  PubMed  CAS  Google Scholar 

  21. Gupta SK, Shah SP, Srivastava A, Kaleekal T. A study of childhood poisoning at National Poisons Information Centre. J. Occup Health. 2003;45:191–6.

    Article  PubMed  Google Scholar 

  22. Gunnel D, Michael E. Suicide by intentional ingestion of pesticides: A continuing tragedy in developing countries. Int J Epidemiol. 2003;32:902–9.

    Article  Google Scholar 

  23. Swisher RD. Surfactant effects on human and other mammals; The soap and Detergent Association Scientific and Technical Report 4. 1966:1–15.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Paediatric Gastroenterology, Hepatology and Transplantation, Global Health City, 439, Cheran Nagar, Perumbakkam, Chennai, 600 100, Tamilnadu, India

    Naresh P. Shanmugam & Chaya Kelgeri

  2. Institute of Liver Diseases and Transplantation, Global Health City, Chennai, India

    Tawfiq Al-Lawati

  3. Department of Paediatric Gastroenterology, Hepatology and Nutrition, The Royal Hospital, Muscat, Sultanate of Oman

    Mohamed Rela

  4. Departments of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Suleyman Demirel University Faculty of Medicine, Cunur, Isparta, Turkey

    Tugba Koca, Selim Dereci & Mustafa Akcam

  5. Department of Pathology; Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey

    Nermin Karahan

  6. DUKE - NUS and YLL NUS Graduate School of Medicine, Singapore, Singapore

    Krishna Gopagondanahalli Revanna

  7. Department of Pediatric Surgery, Columbia Asia Referral Hospital, Yeshwanthpur, Bangalore, Karnataka, India

    Saiprasad & Arvind Kasaragod

  8. Department of Neonatology, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore

    Suresh Chandran

Authors
  1. Naresh P. Shanmugam
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  2. Tawfiq Al-Lawati
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  3. Chaya Kelgeri
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  4. Mohamed Rela
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  5. Tugba Koca
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  6. Selim Dereci
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  7. Nermin Karahan
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  8. Mustafa Akcam
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  9. Krishna Gopagondanahalli Revanna
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  10. Suresh Chandran
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  11. Saiprasad
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  12. Arvind Kasaragod
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Corresponding author

Correspondence to Naresh P. Shanmugam.

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Shanmugam, N.P., Al-Lawati, T., Kelgeri, C. et al. Auxiliary liver transplantation for acute liver failure. Indian Pediatr 53, 67–74 (2016). https://doi.org/10.1007/s13312-016-0795-2

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  • DOI: https://doi.org/10.1007/s13312-016-0795-2

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