Abstract
Objectives
To assess immunogenicity of a single dose of live attenuated hepatitis A vaccine in Indian children, ten years after immunization.
Methods
Of 143 children vaccinated in 2004, 121 children were evaluated in 2014, clinically and for anti-HAV antibodies.
Results
13 children were early vaccine failures who received two doses of HAV vaccine subsequently. 106 (98%) of 108 remaining children had seroprotective levels with a geometric mean titer of 100.5 mIU/mL. On analysis of all 121 children, the immunogenicity was 87.6%.
Conclusion
Single dose of live attenuated hepatitis A vaccine provides long-term immunity in Indian children.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
WHO position paper on hepatitis A vaccines: June 2012–Recommendations. Vaccine. 2013;(31):285–6.
Patwari AK, Shah N. Hepatitis A vaccines. In: Vashishtha VM, Choudhury P, Bansal CP, Yewale VN, Agarwal R, editors. IAP Guidebook on Immunization 2013-14. 1st ed. Gwalior: National Publication House; 2014. p. 249–56.
Vashishtha VM, Choudhury P, Kalra A, Bose A, Thacker N, Yewale VN, et al. Indian Academy of Pediatrics (IAP) Recommended Immunization Schedule for Children Aged 0 through 18 years–India, 2014 and Updates on Immunization. Indian Pediatr. 2014;(51):785–800.
Mao JS, Chai SA, Xie RY, Chen NL, Jiang Q, Zhu XZ, et al. Further evaluation of the safety and protective efficacy of live attenuated hepatitis A vaccine (H2-strain) in humans. Vaccine. 1997;(15):944–7.
Zhuang FC, Qian W, Mao ZA, Gong YP, Jiang Q, Jiang LM, et al. Persistent efficacy of live attenuated hepatitis A vaccine (H2-strain) after a mass vaccination program. Chin Med J (Engl). 2005;(118):1851–6.
Bhave S, Bavdekar A, Madan Z, Jha R, Bhure S, Chaudhari J, et al. Evaluation of immunogenicity and tolerability of a live attenuated hepatitis A vaccine in Indian children. Indian Pediatr. 2006;(43):983–7.
Bhave S, Bavdekar A, Sapru A, Bawangade S, Pandit A. Immunogenicity of single dose live attenuated hepatitis A vaccine. Indian Pediatr. 2011;(48):135–7.
Cobas e 411 Analyzer. Available from: www.rochediagnostics.hu/fmfiles/re7193001/Hungary/roche.hu/Diagnostic/Termekek/CobasE411/cobas_e_411_EN.pdf. Accessed October 7, 2014.
Zhang QY, Chen H, Lin Z, Lin JM. Comparison of chemiluminescence enzyme immunoassay based on magnetic microparticles with traditional colorimetric ELISA for the detection of serum á-fetoprotein. J Pharm Analysis. 2012;(2):130–5.
Wang XY, Xu ZY, Ma JC, von Seidlein L, Zhang Y, Hao ZY, et al. Long-term immunogenicity after single and booster dose of a live attenuated hepatitis A vaccine: results from 8-year follow-up. Vaccine. 2007;(25):446–9.
Fiore AE, Feinstone SM, Bell BP. Hepatitis A vaccines. In: Plotkin SA, Orenstein WA, Offit PA, editors. Vaccines. 5th ed. Philadelphia, PA: Elsevier Inc.; 2008. p. 191.
Ott JJ, Wiersma ST. Single-dose administration of inactivated hepatitis A vaccination in the context of hepatitis A vaccine recommendations. Int J Infect Dis. 2013;17:e939–44.
Faridi MM, Shah N, Ghosh TK, Sankaranarayanan VS, Arankalle V, Aggarwal A, et al. Immunogenicity and safety of live attenuated hepatitis A vaccine: A multicentric study. Indian Pediatr. 2009;46:29–34.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Bhave, S., Sapru, A., Bavdekar, A. et al. Long-term immunogenicity of single dose of live attenuated hepatitis A vaccine in Indian children. Indian Pediatr 52, 687–690 (2015). https://doi.org/10.1007/s13312-015-0697-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13312-015-0697-8