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The role of lysosome in cell death regulation

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Tumor Biology

Abstract

Lysosome is a highly membrane-bound organelle which possesses a sequence of biological functions including protein degradation, cell signal transduction, plasma membrane repairment, homoeostasis, and autophagy. The lysosome contains more than 50 soluble acid hydrolases, and the acidification of lysosome is the most important biological characteristic. The integrity of lysosome is of vital importance. During the past few years, it was reported that the destabilization of lysosomal membrane can result in the release of lysosomal contents into cytosol and trigger cell death in a caspase-dependent or caspase-independent pathway. Lysosome functions at the late stage of autophagy and degrades cellular components delivered by autophagosome, which is a complicated process. The present article will summarize the current knowledge on the role of lysosome in cell death regulation and the underlying mechanisms.

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Acknowledgments

This work was supported by NSFC grant (31370837 and 81573082).

Author information

Authors and Affiliations

  1. Key Laboratory of Radiobiology (Ministry of Health), School of Public Health, Jilin University, Changchun, 130021, China

    Feifei Yu, Zongyan Chen, Benli Wang, Zhao Jin, Yufei Hou, Shumei Ma & Xiaodong Liu

  2. Center for Radiological Research, Columbia University, New York, NY, 10032, USA

    Xiaodong Liu

  3. Department Cancer Care, University of Manitoba, Winnipeg, MB, R3T 3T2, Canada

    Shumei Ma

Authors
  1. Feifei Yu
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  2. Zongyan Chen
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  3. Benli Wang
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  4. Zhao Jin
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  5. Yufei Hou
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  6. Shumei Ma
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  7. Xiaodong Liu
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Corresponding authors

Correspondence to Shumei Ma or Xiaodong Liu.

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Yu, F., Chen, Z., Wang, B. et al. The role of lysosome in cell death regulation. Tumor Biol. 37, 1427–1436 (2016). https://doi.org/10.1007/s13277-015-4516-6

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  • DOI: https://doi.org/10.1007/s13277-015-4516-6

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