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miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151

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Tumor Biology

Abstract

We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.

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Authors and Affiliations

  1. Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Ronglin Zhai, Bo Wang, Hansong Du, Yueping Long, Heshui Wu, Kaixiong Tao & Guobin Wang

  2. Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Xuefeng Kan

  3. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Lihong Bao, Fen Li & Wanli Zhang

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  1. Ronglin Zhai
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  2. Xuefeng Kan
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  3. Bo Wang
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  4. Hansong Du
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  5. Yueping Long
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  6. Heshui Wu
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  7. Kaixiong Tao
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  8. Guobin Wang
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  9. Lihong Bao
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  10. Fen Li
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  11. Wanli Zhang
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Correspondence to Wanli Zhang.

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Zhai, R., Kan, X., Wang, B. et al. miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151. Tumor Biol. 35, 11367–11373 (2014). https://doi.org/10.1007/s13277-014-2471-2

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  • DOI: https://doi.org/10.1007/s13277-014-2471-2

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