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Association of IL-8-251A>T polymorphisms with oral cancer risk: evidences from a meta-analysis

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Tumor Biology

Abstract

The findings of associations between interleukin-8 (IL-8) polymorphisms and risk of oral cancer are controversial. We conducted a meta-analysis on the basis of data from all published studies to provide evidence of the current understanding of the genetic association with oral cancer. Eligible studies were identified by means of an electronic search of PubMed, Elsevier, ScienceDirect, EMBASE, EBSCO, and CBM databases for studies published up to March 2013. In accordance with the inclusion and exclusion criteria, a total of six eligible studies were included in the pooled analyses. In the overall analysis, we did not observe any significant associations between the IL-8-251A>T polymorphism and oral cancer risk under any of the genetic models (all P > 0.05). In the stratified analysis by ethnicity, Caucasian individuals with genotype AA had a higher risk of oral cancer under the dominant model (OR = 1.35, 95 % CI 1.09–1.67, P = 0.006). This meta-analysis indicated that the IL-8-251A>T polymorphism was not associated with the susceptibility of oral cancer, while individuals in the Caucasian population with genotype AA had a higher risk of oral cancer under the dominant model.

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Authors and Affiliations

  1. Department of Clinical Laboratory, The Second People’s Hospital of Nanning, Guangxi, Nanning, China

    Lan Yang, Xu Zhu & Xiuyun Liang

  2. Department of Emergency, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

    Zhian Ling

  3. Department of Medicine Research, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

    Ruolin Li

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  1. Lan Yang
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  2. Xu Zhu
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  3. Xiuyun Liang
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  4. Zhian Ling
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Correspondence to Zhian Ling or Ruolin Li.

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Yang, L., Zhu, X., Liang, X. et al. Association of IL-8-251A>T polymorphisms with oral cancer risk: evidences from a meta-analysis. Tumor Biol. 35, 9211–9218 (2014). https://doi.org/10.1007/s13277-014-2193-5

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  • DOI: https://doi.org/10.1007/s13277-014-2193-5

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