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Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis

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European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

Aim

To evaluate the possible relevance of the IL-18-137 G>C (rs187238), IL-18-607 C>A (rs1946518) and IL-4-590 C>T (rs2243250) polymorphisms to the genetic susceptibility of head and neck cancer.

Methods

Data were retrieved from PubMed, EMBASE, Web of Science and CNKI databases, and the results were independently analysed by two reviewers using Stata 14.0 software.

Results

After searching for and assessing the literature, a total of thirteen studies involving 2,959 patients newly diagnosed as head and neck cancer and 3,622 controls from healthy donors were analysed. The results suggested that a strong relationship between patients and healthy controls was observed in the IL-18-137 G>C polymorphism in consistence with the result (CC vs. GG + GC: OR = 1.63, P = 0.004; CC vs. GG: OR = 1.82, P = 0.001). When stratified by cancer type, ethnicity and the source of control samples, significant and elevated risks were obtained in the genetic susceptibility to Asian patients with NPC in all genetic models and in those studies using the PCR-RFLP test method. In addition, comparable results were obtained for the IL-18-607 C>A polymorphism, especially for Asian patients with NPC.

Conclusions

It should be a potential association between IL-18 variants and nasopharyngeal carcinoma. Furthermore, IL-18 gene variants might be considered as a critical role in predicting the occurrence of nasopharyngeal carcinoma in Asian population. However, the IL-4-590 C>T polymorphism does not influence the development of head and neck cancer.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, China

    Ting-Ting Xiao, Ying Xu & Yong Li

  2. Chongqing Key Laboratory of Oral Disease and Biomedical Sciences, Chongqing, China

    Ting-Ting Xiao, Xian Li, Ying Xu & Yong Li

  3. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China

    Xian Li & Yong Li

Authors
  1. Ting-Ting Xiao
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  2. Xian Li
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  4. Yong Li
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Correspondence to Yong Li.

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Funding

This study was supported by the Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education and the Program for Innovation Team Building at Institutions of Higher Education in Chongqing in 2016, NO CXTDG201602006.

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We declare that we have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Xiao, TT., Li, X., Xu, Y. et al. Significant association of the cytokine variants with head and neck cancer risk: evidence from meta-analysis. Eur Arch Otorhinolaryngol 275, 483–496 (2018). https://doi.org/10.1007/s00405-017-4820-4

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  • DOI: https://doi.org/10.1007/s00405-017-4820-4

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