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Retrospective Analysis of Hyperemesis Gravidarum and Its Psychological Impact during Hospital Admission

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Abstract

Background

The aim of this study was to evaluate hyperemesis gravidarum in pregnant women and its psychological impact.

Methods

This retrospective study included 109 pregnant females suffering from hyperemesis gravidarum admitted during 2019–2020 at Maternity Ain shams university hospital.

Results

Disease severity and laboratory investigations such as Na and K levels (P = 0.007 and < 0.001, respectively) and serum creatinine level (P < 0.001) were significantly positively correlated. Depressive symptoms included guilt feeling for leaving family (49.5% patients), suicidal thoughts (9.2%), crying (56.9%) and lost concentration (33.9%).

Conclusions

Medical staff should be aware of psychological impact of the disease and refer to specialists if needed.

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Data Availability

Data can be shared if required.

References

  1. Nithiyasri P, Monika S, Leelashree T et al. Prevalance and risk factors of hyperemesis gravidarum: a retrospective study. Med Leg Update. 2020;20:132–5. https://doi.org/10.37506/mlu.v20i2.1081.

    Article  Google Scholar 

  2. Gadsby R, Barnie-Adshead AM, Jagger C. A prospective study of nausea and vomiting during pregnancy. Br J Gen Pract. 1993;43:245–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Kim KO. Nausea and vomiting in pregnancy. Korean J Med. 2012;82:525. https://doi.org/10.3904/kjm.2012.82.5.525.

    Article  CAS  Google Scholar 

  4. Brämer GR. International statistical classification of diseases and related health problems. Tenth Revis World Health Stat Q. 1988;41:32–6.

    Google Scholar 

  5. Goodwin TM, Montoro M, Mestman JH. Transient hyperthyroidism and hyperemesis gravidarum: clinical aspects. Am J Obstet Gynecol. 1992;167:648–52.

    Article  CAS  PubMed  Google Scholar 

  6. Tsakiridis I, Mamopoulos A, Athanasiadis A, et al. The management of nausea and vomiting of pregnancy: synthesis of national guidelines. Obstet Gynecol Surv. 2019;74:161–9. https://doi.org/10.1097/OGX.0000000000000654.

    Article  PubMed  Google Scholar 

  7. David M, Borde T, Siedentopf F. Do immigration and acculturation have an impact on hyperemesis gravidarum? Results of a study in Berlin/Germany. J Psychosom Obstet Gynecol. 2012;33:78–84. https://doi.org/10.3109/0167482X.2012.666594.

    Article  Google Scholar 

  8. Matsuo K, Ushioda N, Nagamatsu M, et al. Hyperemesis gravidarum in eastern asian population. Gynecol Obstet Invest. 2007;64:213–6. https://doi.org/10.1159/000106493.

    Article  PubMed  Google Scholar 

  9. Boelig RC, Barton SJ, Saccone G, et al. Interventions for treating hyperemesis gravidarum. Cochrane Database Syst Rev. 2016. https://doi.org/10.1002/14651858.CD010607.pub2.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Austin K, Wilson K, Saha S. Hyperemesis gravidarum. Nutr Clin Pract. 2019;34:226–41. https://doi.org/10.1002/ncp.10205.

    Article  PubMed  Google Scholar 

  11. Sandven I, Abdelnoor M, Nesheim B-I, et al. Helicobacter pylori infection and hyperemesis gravidarum: a systematic review and meta-analysis of case-control studies. Acta Obstet Gynecol Scand. 2009;88:1190–200.

    Article  PubMed  Google Scholar 

  12. Gillispie V, Longo S. Hyperemesis gravidarum. Evid-Based Obstet Gynecol. 2019. https://doi.org/10.1002/9781119072980.ch22.

    Article  Google Scholar 

  13. Ebrahimi N, Maltepe C, Bournissen FG, et al. Nausea and vomiting of pregnancy: using the 24-hour pregnancy-unique quantification of emesis (PUQE-24) scale. J Obstet Gynaecol Can. 2009;31:803–7. https://doi.org/10.1016/S1701-2163(16)34298-0.

    Article  PubMed  Google Scholar 

  14. Veenendaal M, van Abeelen A, Painter R, et al. Consequences of hyperemesis gravidarum for offspring: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2011;118:1302–13. https://doi.org/10.1111/j.1471-0528.2011.03023.x.

    Article  CAS  Google Scholar 

  15. Maltepe C, Koren G. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum–a 2013 update. J Popul Ther Clin Pharmacol. 2013;20:e184-92.

    PubMed  Google Scholar 

  16. Attard CL, Kohli MA, Coleman S, et al. The burden of illness of severe nausea and vomiting of pregnancy in the United States. Am J Obstet Gynecol. 2002;186:S220-7. https://doi.org/10.1067/mob.2002.122605.

    Article  PubMed  Google Scholar 

  17. Mitchell-Jones N, Gallos I, Farren J, et al. Psychological morbidity associated with hyperemesis gravidarum: a systematic review and meta-analysis. BJOG An Int J Obstet Gynaecol. 2017;124:20–30. https://doi.org/10.1111/1471-0528.14180.

    Article  CAS  Google Scholar 

  18. Vikanes A, Grjibovski AM, Vangen S, et al. Variations in prevalence of hyperemesis gravidarum by country of birth: a study of 900,074 pregnancies in Norway, 1967–2005. Scand J Public Health. 2008;36:135–42. https://doi.org/10.1177/1403494807085189.

    Article  PubMed  Google Scholar 

  19. Kjeldgaard HK, Eberhard-Gran M, Benth JŠ, et al. Hyperemesis gravidarum and the risk of emotional distress during and after pregnancy. Arch Womens Ment Health. 2017;20:747–56. https://doi.org/10.1007/s00737-017-0770-5.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Havnen GC, Truong MBT, Do MLH, et al. Women’s perspectives on the management and consequences of hyperemesis gravidarum–a descriptive interview study. Scand J Prim Health Care. 2019;37:30–40. https://doi.org/10.1080/02813432.2019.1569424.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Mazzota P, Magee L, Koren G. Therapeutic abortions due to severe morning sickness. Unaccept Comb Can Fam Phys. 1997;43:1055–7.

    CAS  Google Scholar 

  22. Koren G, Levichek Z. The teratogenicity of drugs for nausea and vomiting of pregnancy: perceived versus true risk. Am J Obstet Gynecol. 2002;186:S248–52. https://doi.org/10.1067/mob.2002.122601.

    Article  CAS  PubMed  Google Scholar 

  23. Shim S-M, Ryu A-L, Kim Y-S. Acute kidney injury arising from severe hyperemesis gravidarum: case report with a review of literatures. Soonchunhyang Med Sci. 2015;21:28–30. https://doi.org/10.0000/sms.2015.21.1.28.

    Article  Google Scholar 

  24. Senturk MB, Yıldız G, Yıldız P, et al. The relationship between hyperemesis gravidarum and maternal psychiatric well-being during and after pregnancy: controlled study. J Matern Neonatal Med. 2017;30:1314–9. https://doi.org/10.1080/14767058.2016.1212331.

    Article  Google Scholar 

  25. McCarthy FP, Khashan AS, North RA, et al. A prospective cohort study investigating associations between hyperemesis gravidarum and cognitive, behavioural and emotional well-being in pregnancy. PLoS One. 2011;6:e27678. https://doi.org/10.1371/journal.pone.0027678.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Mitchell-Jones N, Lawson K, Bobdiwala S, et al. Association between hyperemesis gravidarum and psychological symptoms, psychosocial outcomes and infant bonding: a two-point prospective case-control multicentre survey study in an inner city setting. BMJ Open. 2020;10:e039715. https://doi.org/10.1136/bmjopen-2020-039715.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

The authors acknowledge the contribution of Ain Shams Hospital manager and medical students who helped us in completing our research.

Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

    Rania Gamal Anwar El-Skaan, Rehab Mohamed Abdelrahman & Ahmed Mohamed Abdelhamed Hassan

Authors
  1. Rania Gamal Anwar El-Skaan
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  2. Rehab Mohamed Abdelrahman
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  3. Ahmed Mohamed Abdelhamed Hassan
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Contributions

Protocol design: AMA; Data collection, analysis, and manuscript writing: RGElS; Manuscript writing: RMA.

Corresponding author

Correspondence to Rania Gamal Anwar El-Skaan.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical Approval

The study was approved by the Institutional Review Board of Ain Shams University. We also recorded the treatment received and any intervention needed, need for ICU admission and condition of patient on discharge from the medical records of the Obstetrics and Gynecology Department, Ain Shams Maternity Hospital. The research protocols used in this research were approved by the local Institutional Review Board and in accordance with the Declaration of Helsinki.

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Rania Gamal Anwar EL-skaan (MD), Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Rehab Mohamed Abdel Rahman (MD),Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Ahmed Mohamed Abdelhamed Hassan (MD), Department of Obstetrics and Gynecology, Faculty of Medicine, Ain Shams University, Cairo, Egypt

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El-Skaan, R.G.A., Abdelrahman, R.M. & Hassan, A.M.A. Retrospective Analysis of Hyperemesis Gravidarum and Its Psychological Impact during Hospital Admission. J Obstet Gynecol India 73 (Suppl 1), 19–24 (2023). https://doi.org/10.1007/s13224-023-01787-3

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  • DOI: https://doi.org/10.1007/s13224-023-01787-3

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