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Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome

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Abstract

Objective

To find the prevalence of thyroid autoimmunity in PCOS women of reproductive age group.

Methods

Study design: Observational study was done at ESIMC and PGIMSR K.K. Nagar March 2013–Feb 2014. Ninety cases of women with PCOS based on Rotterdam’s criteria and an equal number of age-matched controls (women without PCOS) were included in the study. Thyroid profile, antithyroid peroxidase titre, serum progesterone, testosterone and fasting blood sugar were estimated using standardised techniques.

Results

Menstrual irregularity (oligomenorrhoea and amenorrhoea) was the most common abnormality found in patients with PCOS compared with non-PCOS (p < 0.0001). Hyperandrogenism was the second most common manifestation present in PCOS of our study group. Hirsutism was the striking hyperandrogenic feature that was present in study group. PCOS patients had higher BMI compared to controls (p < 0.0001). The prevalence of thyroid dysfunction was not significantly different in both the groups (p < 0.80). Anti-TPO titre was higher in PCOS patients (25.8 ± 2.9 IU/ml) compared to the controls (14.5 ± 2.3 IU/ml) (p < 0.009).

Conclusion

The present study shows that PCOS was associated with increased anti-TPO titres, thus emphasising the importance of screening all PCOS patients for anti-TPO along with routine thyroid profile.

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References

  1. Al Saab R, Haddad S. Detection of thyroid autoimmunity markers in euthyroid women with polycystic ovary syndrome: a case control study from Syria. Int J Endocrinol Metab. 2014;12(3):e17954.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Macklon NS. Polycystic ovary syndome. BMJ. 2011;343:d6407.

    Article  PubMed  Google Scholar 

  3. Janseen OE, Mehlmauer N, Hahn S, et al. High prevalence of autoimmune thyroidits in patients with polycystic ovary syndrome. Eur J Endocrinol. 2004;150(3):363–9.

    Article  Google Scholar 

  4. Artini PG, Uccelli A, Papini F, et al. Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity. Gynecol Endocrinol. 2013;29(1):36–41.

    Article  CAS  PubMed  Google Scholar 

  5. Poppe K, Velkeniers B, Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008;4(7):394–405.

    Article  CAS  PubMed  Google Scholar 

  6. Melmed S, Polonsky KS, Larsen PR, et al. Williams textbook of endocrinology. PCOS. 2015;13:954–65.

    Google Scholar 

  7. Rotterdam EAPCWG. Revised 2003 consensus on diagnostic criteria and long term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41–7.

    Article  Google Scholar 

  8. Balen AH, Laven JS, Tan ST, et al. Ultrasound assessment of the polycystic ovary, international consensus definitions. Hum Reprod Update. 2003;9(6):505–14.

    Article  PubMed  Google Scholar 

  9. Petrikova J, Lazurova I, Yehuda S. Polycystic ovary syndrome and autoimmunity. Eur J Intern Med. 2010;21(5):369–71.

    Article  PubMed  Google Scholar 

  10. Ganie MA, Marwaha RK, Aggarwal R, et al. High prevalence of polycystic ovary syndrome characteristics in girls with euthyroid chronic lymphocytic thyroiditis: a case control study. Eur J Endocrinol. 2010;162(6):1117–22.

    Article  CAS  PubMed  Google Scholar 

  11. Petrikova J, Lazurova I, Yehuda S. Polycystic ovarian syndrome and auto immunity. Eur J Intern Med. 2010;21:369–71.

    Article  PubMed  Google Scholar 

  12. Sinha U, Sinharay K, Saha S, et al. Thyroid disorders in polycystic ovarian syndrome subjects: a tertiary hospital based cross sectional study from Eastern India. Indian J Endocrinol Metab. 2013;17(2):304–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Singla R, Gupta Y, Khemani M, et al. Thyroid disorders and polycystic ovary syndrome: an emerging relationship. Indian J Endocrinol Metab. 2015;19(1):25–9. doi:10.103/2230-8210.1468606.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Anaforoglu I, Topbas M, Algun E. Relative association of polycystic ovarian syndrome and metabolic syndrome with thyroid function, volume, nodularity and autoimmunity. J Endocrinol Invest. 2011;34(9):e259–64. doi:10.3275/7681.

    CAS  PubMed  Google Scholar 

  15. Duran C, Basaran M, Kutlu O. Frequency of nodular goiter and autoimmune thyroiditis in patients with polycystic ovarian syndrome. J Endocr. 2015;49(2):464–9.

    Article  CAS  Google Scholar 

  16. Garelli S, Masiero S, Plebani M, et al. High prevalence of chronic thyroiditis in patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2013;169:248–51.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology, ESIC Medical College and PGIMSR, Chennai, 600078, India

    Maya Menon & Vijayalakshmi Ramachandran

Authors
  1. Maya Menon
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  2. Vijayalakshmi Ramachandran
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Corresponding author

Correspondence to Maya Menon.

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Conflict of interest

All the authors note that there is no conflict of interest.

Ethical Approval

All procedures performed in study involving human participants were in accordance with ethical standards of the institutional and/or national research committee and with the Helsinki Declaration revised 2008.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Additional information

Dr. Maya Menon is a Associate Professor in Department of Obstetrics and Gynaecology at ESIC Medical College and PGIMSR; Dr. Vijayalakshmi Ramachandran is a postgraduate in Department of Obstetrics and Gynaecology at ESIC Medical College and PGIMSR.

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Menon, M., Ramachandran, V. Antithyroid Peroxidase Antibodies in Women with Polycystic Ovary Syndrome. J Obstet Gynecol India 67, 61–65 (2017). https://doi.org/10.1007/s13224-016-0914-y

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  • DOI: https://doi.org/10.1007/s13224-016-0914-y

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