Abstract
This paper reports various types of cancer, their incidence, and prevalence all over the globe. Along with the discovery of novel natural drugs for cancer treatment, these present a promising option which are eco-friendly, safe, and provide better acceptability in comparison to synthetic agents that carries multiple side effects. This paper provides an idea about various nanocarriers and phytochemicals, along with how their solubility and bioavailability can be enhanced in nanocarrier system. This report combines the data from various literature available on public domain including PubMed on research articles, reviews, and along with report from various national and international sites. Specialized metabolites (polyphenols, alkaloids, and steroids etc) from medicinal plants are promising alternatives to existing drugs. Studies have suggested that the treatment of cancer using plant products could be an alternative and a safe option. Studies have shown with the several cell lines as well as animal models, that phytomolecules are important in preventing/treating cancer. Phytochemicals often outperform chemical treatments by modulating a diverse array of cellular signaling pathways, promoting cell cycle arrest, apoptosis activation, and metastatic suppression, among others. However, limited water solubility, bioavailability, and cell penetration limit their potential clinical manifestations. The development of plant extract loaded nanostructures, rendering improved specificity and efficacy at lower concentrations could prove effective. Nanocarriers, such as liposomes, nanostructured lipids, polymers, and metal nanoparticles, have been tested for the delivery of plant products with enhanced effects. Recent advances have achieved improvement in the the stability, solubility, bioavailability, circulation time, and target specificity by nanostructure-mediated delivery of phytochemicals. Nanoparticles have been considered and attempted as a novel, targeted, and safe option. Newer approaches such as phyto-nanocarriers with carbohydrates, lignin, and polymers have been considered even more selective and effective modes of drug delivery in biomedical or diagnostic applications.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
5. References
Acebes-Fernández V, Landeira-Viñuela A, Juanes-Velasco P, Hernández AP, Otazo-Perez A, Manzano-Román R, Gongora R, Fuentes M (2020) Nanomedicine and onco-immunotherapy: from the bench to bedside to biomarkers. Nanomaterials 10:1274. https://doi.org/10.3390/nano10071274
Agarwal H, Menon S, Kumar SV, Rajeshkumar S (2018) Mechanistic study on antibacterial action of zincoxide nanoparticles synthesized using green route. Chemico-Biol Interact 286:60–70. https://doi.org/10.1016/j.cbi.2018.03.008
Aghebati-Maleki A, Dolati S, Ahmadi M, Baghbanzhadeh A, Asadi M, Fotouhi A, Yousefi M, Aghebati-Maleki L (2020) Nanoparticles and cancer therapy: perspectives for application of nanoparticles in the treatment of cancers. J Cell Physiol 235:1962–1972. https://doi.org/10.1002/jcp.29126
Ahlawat J, Henriquez G, Narayan M (2018) Enhancing the delivery of chemotherapeutics: role of biodegradable polymeric nanoparticles. Molecules. https://doi.org/10.3390/molecules23092157
Akhtar MJ, Ahamed M, Alhadlaq HA, Alrokayan SA, Kumar S (2014) Targeted anticancer therapy: overexpressed receptors and nanotechnology. Clin Chim Acta 436:78–92. https://doi.org/10.1016/j.cca.2014.05.004
Almatroodi SA, Alsahli MA, Almatroudi A, Verma AK, Aloliqi A, Allemailem KS, Rahmani AH (2021) Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules 26(5):1315. https://doi.org/10.3390/molecules26051315
Al-Shabib NA, Husain FM, Qais FA, Ahmad N, Khan A, Alyousef AA, Shahzad SA (2020) Phyto-mediated synthesis of porous titanium dioxide nanoparticles from Withania somnifera root extract: broad-spectrum attenuation of biofilm and cytotoxic properties against HepG2 cell lines. Front Microbiol 11:1680. https://doi.org/10.3389/fmicb.2020.01680
Amarowicz R, Pegg RB (2019) Natural antioxidants of plant origin. Advances in food and nutrition research, vol 90. Academic Press, New York, pp 1–81. https://doi.org/10.1016/bs.afnr.2019.02.01
American Cancer Society (2016) Cancer facts and figures 2016. American Cancer Society, Atlanta
Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Aggarwal BB (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116. https://doi.org/10.1007/s11095-008-9661-9
Andleeb A, Andleeb A, Asghar S, Zaman G, Tariq M, Mehmood A, Abbasi BH (2021) A systematic review of biosynthesized metallic nanoparticles as a promising anti-cancer-strategy. Cancers 13(11):2818. https://doi.org/10.3390/cancers13112818
Arunachalam KD, Arun LB, Annamalai SK, Arunachalam AM (2015) Potential anticancer properties of bioactive compounds of Gymnema sylvestre and its biofunctionalized silver nanoparticles. Int J Nanomed 10:31. https://doi.org/10.2147/IJN.S71182.eCollection2015
Ashrafizadeh M, Zarrabi A, Hushmandi K, Zarrin V, Moghadam ER, Hashemi F, Mirzaei H (2020) Toward regulatory effects of curcumin on transforming growth factor-beta across different diseases: a review. Front Pharmacol. https://doi.org/10.3389/fphar.2020.585413
Astefanei A, Núñez O, Galceran MT (2015) Characterisation and determination of fullerenes: a critical review. Anal Chim Acta 882:1–21. https://doi.org/10.1016/j.aca.2015.03.025
Avato P, Argentieri MP (2015) Brassicaceae: a rich source of health improving phytochemicals. Phytochem Rev 14:1019–1033. https://doi.org/10.1007/s11101-015-9414-4
Avgerinos KI, Spyrou N, Mantzoros CS, Dalamaga M (2019) Obesity and cancer risk: emerging biological mechanisms and perspectives. Metabolism 92:121–135. https://doi.org/10.1016/j.metabol.2018.11.001
Baharara J, Namvar F, Ramezani T, Mousavi M, Mohamad R (2015) Silver nanoparticles biosynthesized using Achillea biebersteinii flower extract: apoptosis induction in MCF-7 cells via caspase activation and regulation of Bax and Bcl-2 gene expression. Molecules 20:2693–2706. https://doi.org/10.3390/molecules20022693
Banerjee K, Das S, Choudhury P, Ghosh S, Baral R, Choudhuri SK (2017) A novel approach of synthesizing and evaluating the anticancer potential of silver oxide nanoparticles in vitro. Chemotherapy 62:279–289. https://doi.org/10.1159/000453446
Bao R, Shu Y, Wu X, Weng H, Ding Q, Cao Y, Li M, Mu J, Wu W, Ding Q (2014) Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway. BMC Cancer 14:1–13. https://doi.org/10.1186/1471-2407-14-217
Baskar AA, Ignacimuthu S, Paulraj GM, Al Numair KS (2010) Chemopreventive potential of β-sitosterol in experimental colon cancer model-an in vitro and in vivo study. BMC Complement Altern Med 10:1–10. https://doi.org/10.1186/1472-6882-10-24
Behera B, Pradhan S, Samantaray A, Pradhan D (2020) Antiproliferative and cytotoxic activity of Hematite (-Fe2O3) nanoparticles from Butea monosperma on MCF-7 Cells. Afr J Pharm Pharmacol 14(2):29–40. https://doi.org/10.5897/AJPP2019.5111
Bhattacharyya S, Kudgus RA, Bhattacharya R, Mukherjee P (2011) Inorganic nanoparticles in cancer therapy. Pharm Res 28:237–259. https://doi.org/10.1007/s11095-010-0318-0
Boubaker J, Ben Toumia I, Sassi A, Bzouich-Mokded I, Ghoul Mazgar S, Sioud F, Bedoui A, Safta Skhiri S, Ghedira K, Chekir-Ghedira L (2018) Antitumoral potency by immunomodulation of chloroform extract from leaves of Nitraria retusa, Tunisian medicinal plant, via its major compounds -sitosterol and palmitic acid in BALB/c mice bearing induced tumor. Nutr Cancer 70:650–662. https://doi.org/10.1080/01635581.2018.1460683
Boutayeb A, Boutayeb S (2005) The burden of non communicable diseases in developing countries. Int J Equity Health 4:1–8. https://doi.org/10.1186/1475-9276-4-2
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424. https://doi.org/10.3322/caac.21492
Carneiro LJ, Tasso TO, Santos MF, Goulart MO, Santos RAD, Bastos JK, da Silva JJ, Crotti AE, Parreira RL, Orenha RP, Veneziani R (2020) Copaifera multijuga, Copaifera pubiflora and Copaifera trapezifolia oleoresins: chemical characterization and in vitro cytotoxic potential against tumoral cell lines. J Braz Chem Soc 3:1679–1689. https://doi.org/10.2157/0103-5053.20200054
Chamcheu JC, Roy T, Uddin MB, Banang-Mbeumi S, Chamcheu RN, Walker AL, Liu YY, Huang S (2019) Role and therapeutic targeting of the PI3K/Akt/mTOR signaling pathway in skin cancer: a review of current status and future trends on natural and synthetic agents therapy. Cells 8(8):803. https://doi.org/10.3390/cells8080803
Chanthini AB, Balasubramani G, Ramkumar R, Sowmiya R, Balakumaran MD, Kalaichelvan PT, Perumal P (2015) Structural characterization, antioxidant and in vitro cytotoxic properties of seagrass, Cymodocea serrulata (R.Br.) Asch. and magnus mediated silver nanoparticles. J Photochem Photobiol B 153:145–152. https://doi.org/10.1016/j.jphotobiol.2015.09.014
Cheng Z, Li M, Dey R, Chen Y (2021) Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol 14(1):85. https://doi.org/10.1186/s13045-021-01096-0
Chou CW, Batnyam O, Hung HS, Harn HJ, Lee WF, Lin HR (2013) Highly bioavailable anticancer herbal-loaded nanocarriers for use against breast and colon cancer in vitro and in vivo systems. Polym Chem 4(6):2040–2052
Choudhari AS, Mandave PC, Deshpande M, Ranjekar P, Prakash O (2020) Phytochemicals in cancer treatment: from preclinical studies to clinical practice. Front Pharmacol. https://doi.org/10.3389/fphar.2019.01614
Christina F, Christopher JL, Murray TA (2019) Global Burden of Disease Cancer Collaboration. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability and disability-adjusted life-years for 29 cancer groups, 1990 to 2017. JAMA Oncol 5:1–21. https://doi.org/10.1001/jamaoncol.2019.2996
Clarke TC, Black LI, Stussman BJ et al (2015) Trends in the use of complementary health approaches among adults: United States, 2002–2012. Natl Health Stat Report 79:1
Conde J, Doria G, Baptista P (2012) Noble metal nanoparticles applications in cancer. J Drug Deliv. https://doi.org/10.1155/2012/751075
Conde J, Rosa J, Lima JC, Baptista PV (2012) Nanophotonics for molecular diagnostics and therapy applications. Int J Photoenergy. https://doi.org/10.1155/2012/619530b
Devaraj P, Aarti C, Kumari P (2014) Synthesis and characterization of silver nanoparticles using Tabernaemontana divaricata and its cytotoxic activity against MCF7 cell line. Int J Pharm Sci 6:86–90
Dhupal M, Chowdhury D (2020) Phytochemical-based nanomedicine for advanced cancer theranostics: perspectives on clinical trials to clinical use. Int J Nanomed 15:9125. https://doi.org/10.2147/IJN.S259628
Diwan D, Cheng L, Usmani Z, Sharma M, Holden N, Willoughby N, Sangwan N, Raju R, Liu C, Gupta VK (2021) Microbial cancer therapeutics: a promising approach. Semin Cancer Biol S1044-579X(21) 00131-0
Dreaden EC, Alkilany AM, Huang X, Murphy CJ, El-Sayed MA (2012) The golden age: gold nanoparticles for biomedicine. Chem Soc Rev 41:2740–2779. https://doi.org/10.1039/c1cs15237h
Dutta D, Paul B, Mukherjee B, Mondal L, Sen S, Chowdhury C, Debnath MC (2019) Nanoencapsulated betulinic acid analogue distinctively improves colorectal carcinoma in vitro and in vivo. Sci Rep 9:1–20. https://doi.org/10.1038/s41598-019-47743-y
Elangovan K, Elumalai D, Anupriya S, Shenbhagaraman R, Kaleena P, Murugesan K (2015) Phyto mediated biogenic synthesis of silver nanoparticles using leaf extract of Andrographis echioides and its bioefficacy on anticancer and antibacterial activities. J Photochem Photobiol B Biol 151:118–124. https://doi.org/10.1016/j.jphotobiol.2015.05.015
Elisabete W (2010) Lifestyle and cancer risk. J Prevent Med Public Health 43(6):459–471. https://doi.org/10.3961/jpmph.2010.43.6.459
Fimognari C, Turrini E, Ferruzzi L, Lenzi M, Hrelia P (2012) Natural isothiocyanates: genotoxic potential versus chemoprevention. Mutat Res 750:107–131. https://doi.org/10.1016/j.mrrev.2011.12.001
Firdhouse J, Lalitha P (2015) Apoptotic efficacy of biogenic silver nanoparticles on human breast cancer MCF-7 cell lines. Prog Biomater 4:113–121. https://doi.org/10.1007/s40204-015-0042-2
Firdhouse MJ, Lalitha P (2020) Facile synthesis of anisotropic gold nanoparticles and its synergistic effect on breast cancer cell lines. IET Nanobiotechnol 14(3):224–229. https://doi.org/10.1049/iet-nbt.2019.0279
García-Pinel B, Porras-Alcalá C, Ortega-Rodríguez A, Sarabia F, Prados J, Melguizo C, López-Romero JM (2019) Lipid-based nanoparticles: application and recent advances in cancer treatment. Nanomaterials 9:638. https://doi.org/10.3390/nano9040638
Gaziano JM, Glynn RJ, Christen WG, Kurth T, Belanger C, MacFadyen BJE (2009) Vitamins E and C in the prevention of prostate and total cancer in men: the Physicians’ Health Study II randomized controlled trial. JAMA 301(1):52–62. https://doi.org/10.1001/jama.2008.862
Ge J, Liu Y, LiQ GX, Gu L, Ma ZG, Zhu YP (2013) Resveratrol induces apoptosis and autophagy in T-cell acute lymphoblastic leukemia cells by inhibiting Akt/mTOR and activating p38-MAPK. Biomed Environ Sci 26:902–911. https://doi.org/10.3967/bes2013.019
Gobinath P, Packialakshmi P, Hatamleh AA, Al-Dosary MA, Al-Wasel YA, Balasubramani R, Idhayadhulla A (2022) Calotropis gigantea assisted synthesis of zinc oxide nanoparticle catalysis: synthesis of novel 3-amino thymoquinone connected 1, 4-dihyropyridine derivatives and their cytotoxic activity. J Nanomater. https://doi.org/10.1155/2022/9697057
Gomaa EZ (2013) In vitro antioxidant, antimicrobial, and antitumor activities of bitter almond and sweet apricot (Prunus armeniaca L.) kernels. Food Sci Biotechnol 22:455–463. https://doi.org/10.1007/s10068-013-0101-1
Gomes HIO, Martins CSM, Prior JAV (2021) Silver nanoparticles as carriers of anticancer drugs for efficient target treatment of cancer cells. Nanomaterials 11:964. https://doi.org/10.1007/s10068-013-0101-1
Greenwell M, Rahman PKSM (2015) Medicinal plants: their use in anticancer treatment. Int J Pharm Sci Res 6:4103. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12
Gupta B, Johnson NW, Kumar N (2016) Global epidemiology of head and neck cancers: a continuing challenge. Oncology 91(1):13–23. https://doi.org/10.1159/000446117
Gupta S, Hemlata H, Tejavath K (2020) Synthesis, characterization and comparative anticancer potential of phytosynthesized mono and bimetallic nanoparticles using Moringa oleifera aqueous leaf extract. Beilstein Arch 1:95. https://doi.org/10.3762/bxiv.2020.95.v1
Gurunathan S, Jeong JK, Han JW, Zhang XF, Park JH, Kim JH (2015) Multidimensional effects of biologically synthesized silver nanoparticles in Helicobacter pylori, Helicobacter felis, and human lung (L132) and lung carcinoma A549 cells. Nanoscale Res Lett 10:1–17. https://doi.org/10.1186/s11671-015-0747-0
Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013
Haura EB, Turkson J, Jove R (2005) Mechanisms of disease: Insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2:315–324. https://doi.org/10.1038/ncponc0195
He Y, Du Z, Ma S, Cheng S, Jiang S, Liu Y, Li D, Huang H, Zhang K, Zheng X (2016a) Biosynthesis, antibacterial activity and anticancer effects against prostate cancer (PC-3) cells of silver nanoparticles using Dimocarpus longan Lour. Nanoscale Res Lett 11:1–10. https://doi.org/10.1186/s11671-016-1511-9
He Y, Du Z, Ma S, Liu Y, Li D, Huang H, Jiang S, Cheng S, Wu W, Zhang K (2016b) Effects of green synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors in vivo. Int J Nanomed 11:1879a. https://doi.org/10.2147/IJN.S103695
Huynh J, Etemad N, Hollande F, Ernst M, Buchert M (2017) The JAK/STAT3 axis: a comprehensive drug target for solid malignancies. Seminars in cancer biology, vol 45. Academic Press, New York, pp 13–22. https://doi.org/10.1016/j.semcancer.2017.06.001
Imtiaz T, Rajeshkumar S, Ezhilarasan D, Lakshmi T (2022) Preparation of Ficus benghalensis mediated copper nanoparticles and its based mouthwash and to check its cytotoxic activity. Int J Early Childh 14(03):2022
Indoria S, Singh V, Hsieh MF (2020) Recent advances in theranostic polymeric nanoparticles for cancer treatment: a review. Int J Pharm 582:119314. https://doi.org/10.1016/j.ijpharm.2020.119314
Iqbal SZ, Jubeen F, Sher F (2019) Future of 5-fluorouracil in cancer therapeutics, current pharmacokinetics issues and a way forward. J Cancer Res Pract 6(4):155. https://doi.org/10.4103/JCRP.JCRP_10_19
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69–90. https://doi.org/10.3322/caac.20107
Jubeen F, Liaqat A, Sultan M, Zafar Iqbal S, Sajid I, Sher F (2019) Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents. Saudi Pharm J 27(8):1164–1173. https://doi.org/10.1016/j.jsps.2019.09.013
Jubeen F, Liaqat A, Amjad F, Sultan M, Iqbal SZ, Sajid I, Sher F (2020) Synthesis of 5-fluorouracil cocrystals with novel organic acids as coformers and anticancer evaluation against HCT-116 colorectal cell lines. Cryst Growth Des 20(4):2406–2414. https://doi.org/10.1021/acs.cgd.9b01570
Kabeer FA, Rajalekshmi DS, Nair MS, Prathapan R (2019) In vitro and in vivo antitumor activity of deoxyelephantopin from a potential medicinal plant Elephantopus scaber against Ehrlich ascites carcinoma. Biocatal Agric Biotechnol 19:101106. https://doi.org/10.1016/j.bcab.2019.101106
Kabir SR, Asaduzzaman AKM, Amin R, Haque AT, Ghose R, Rahman MM, Alam MT (2020) Zizyphus mauritiana fruit extract-mediated synthesized silver/silver chloride nanoparticles retain antimicrobial activity and induce apoptosis in MCF-7 cells through the Fas pathway. ACS Omega 5(32):20599–20608. https://doi.org/10.1021/acsomega.0c02878
Kapusta-Duch J, Kopec A, Piatkowska E, Borczak B, Leszczynska T (2012) The beneficial effects of Brassica vegetables on human health. Roczniki Państwowego Zakładu Higieny 63
Karikas GA (2010) Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects. J BUON 15:627–638
Katzke VA, Kaaks R, Kühn T (2015) Lifestyle and cancer risk. Cancer J 21(2):104–110. https://doi.org/10.1097/PPO.0000000000000101
Khan AQ, Kuttikrishnan S, Siveen KS, Prabhu KS, Shanmugakonar M, Al-Naemi HA, Haris M, Dermime S, Uddi S (2019a) RAS-mediated oncogenic signaling pathways in human malignancies. Seminars in cancer biology, vol 54. Academic Pressa, New York, pp 1–13. https://doi.org/10.1016/j.semcancer.2018.03.001
Khan I, Saeed K, Khan I (2019b) Nanoparticles: properties, applications and toxicities. Arab J Chem 12:908–931b. https://doi.org/10.1016/j.arabjc.2017.05.011
Khan T, Ali M, Khan A, Nisar P, Jan SA, Afridi S, Shinwari ZK (2020) Anticancer plants: a review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules 10:47. https://doi.org/10.3390/biom10010047
Kikuchi T, NiheiM NH, Fukushi H, Tabata K, Suzuki T, Akihisa T (2010) Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line. Chem Pharm Bull 58:568–571. https://doi.org/10.1248/cpb.58.568
Kim B, Park JE, Im E, Cho Y, Lee J, Lee HJ, Kim SH (2021) Recent advances in nanotechnology with nano-phytochemicals: molecular mechanisms and clinical implications in cancer progression. Int J Mol Sci 22(7):3571. https://doi.org/10.3390/ijms22073571
Kirar S, Chaudhari D, Thakur NS, Jain S, Bhaumik J, Laha JK, Banerjee UC (2021) Light-assisted anticancer photodynamic therapy using porphyrin-doped nanoencapsulates. J Photochem Photobiol B 220:112209. https://doi.org/10.1016/j.jphotobiol.2021.112209
Ko JH, Sethi G, Um JY, Shanmugam MK, Arfuso F, Kumar AP, Ahn KS (2017) The role of resveratrol in cancer therapy. Int J Mol Sci 18:2589. https://doi.org/10.3390/ijms18122589
Korani S, Rashidi K, Hamelian M, Jalalvand AR, Tajehmiri A, Korani M, Sahebkar A (2021) Evaluation of antimicrobial and wound healing effects of gold nanoparticles containing Abelmoschus esculentus (L.) aqueous extract. Bioinorgan Chem Appl. https://doi.org/10.1155/2021/7019130
Kowalczyk T, Sitarek P, Skała E, Toma M, Wielanek M, PytelD WJ, Szemraj J, Śliwiński T (2019) Induction of apoptosis by in vitro and in vivo plant extracts derived from Menyanthes trifoliata L. in human cancer cells. Cytotechnology 71:165–180. https://doi.org/10.1007/s10616-018-0274-9
Krishnan V, Bupesh G, Manikandan E, Thanigai AK, Magesh S, Kalyanaraman R, Maaza M (2016) Green synthesis of silver nanoparticles using Piper nigrum concoction and its anticancer activity against MCF-7 and Hep-2 cell lines. J Antimicro 2(3):2472–1212. https://doi.org/10.4172/2472-1212.1000123
Lakshmi S, Suresh S, Rahul BS, SaikantR MV, Gopi M, Padmaja G, Remani P (2019) In vitro and in vivo studies of 5, 7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma. Med Chem Res 28:39–51. https://doi.org/10.1007/s00044-018-2260-3
Lee HJ, Cho HS, Jun S, Lee JJ, Yoon J, Lee JH, Song H, Choi S, Kim S, Saloura V et al (2014) Tussilago farfara L. augments TRAIL-induced apoptosis through MKK7/JNK activation by inhibition of MKK7TIPRL in human hepatocellular carcinoma cells. Oncol Rep 32:1117–1123. https://doi.org/10.3892/or.2014.3279
Li J, Sun J, Song J (2012) Experimental research on effect of Hedyotis diffusa Willd on blood metastasis in H22 mice. Lishizhen Med Mater Med Res 23:2434–2435. https://doi.org/10.3390/molecules21060710
Li Y, Gu JF, Zou X, Wu J, Zhang MH, Jiang J, Qin D, Zhou JY, Liu BXZ, Zhu YT (2013) The anti-lung cancer activities of steroidal saponins of P. polyphylla Smith var. chinensis (Franch.) Hara through enhanced immunostimulation in experimental Lewis tumor-bearing C57BL/6 mice and induction of apoptosis in the A549 cell line. Molecules 18:12916–12936. https://doi.org/10.3390/molecules181012916
Li P, Kumar AS, Wu SB, Liu B, Guo ZY, FataJE KEJ, Long CL (2016) Comparative UPLC-QTOF-MS-based metabolomics and bioactivities analyses of Garcinia oblongifolia. J Chromatogr B 1011:179–195. https://doi.org/10.1016/j.jchromb.2015.12.061
Li F, Wang W, Xiao H (2019) The evaluation of anti-breast cancer activity and safety pharmacology of the ethanol extract of Aralia elata Seem. leaves. Drug Chem Toxicol. https://doi.org/10.1080/01480545.2019.1601211
Liu Q, Wu F, Chen Y, Alrashood ST, Alharbi SA (2021) Anti-human colon cancer properties of a novel chemotherapeutic supplement formulated by gold nanoparticles containing Allium sativum L. leaf aqueous extract and investigation of its cytotoxicity and antioxidant activities. Arab J Chem 14(4):103039. https://doi.org/10.1016/j.arabjc.2021.103039
Lohse I, Wildermuth E, Brothers SP (2018) Naturally occurring compounds as pancreatic cancer therapeutics. Oncotarget 9:35448. https://doi.org/10.18632/oncotarget.26234
MacEwan SR, Callahan DJ, Chilkoti A (2010) Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery. Nanomedicine 5:793–806. https://doi.org/10.2217/nnm.10.50
Madakka M, Jayaraju N, Rajesh N (2021) Evaluating the antimicrobial activity and antitumor screening of green synthesized silver nanoparticles compounds, using Syzygium jambolanum, towards MCF7 cell line (Breast cancer cell line). J Photochem Photobiol 6:100028. https://doi.org/10.1016/j.jpap.2021.100028
Mader JS, Hoskin DW (2006) Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin Investig Drugs 15:933–946. https://doi.org/10.1517/13543784.15.8.933
Maheswari P, Harish S, Navaneethan M, Muthamizhchelvan C, PonnusamyS HY (2020) Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications. Mater Sci Eng C 108:110457. https://doi.org/10.1016/j.msec.2019.110457
Mandrich L, Caputo E (2020) Brassicaceae-derived anticancer agents: towards a green approach to beat cancer. Nutrients 12:868. https://doi.org/10.3390/nu12030868
Manjamalai A, Grace V (2012) Antioxidant activity of essential oils from Wedelia chinensis (Osbeck) in vitro and in vivo lung cancer bearing C57BL/6 mice. Asian Pac J Cancer Prev 13:3065–3071. https://doi.org/10.7314/apjcp.2012.13.7.3065
Mansha M, Khan I, Ullah N, Qurashi A (2017) Synthesis, characterization and visible-light-driven photoelectrochemical hydrogen evolution reaction of carbazole-containing conjugated polymers. Int J Hydrogen Energy 42:10961. https://doi.org/10.1016/j.dyepig.2017.04.028
Maqsood M, Mushtaq Z, Rasheed T, Nisa ZU, Sher F (2021) Thrombolytic and cytotoxic activity of different bioactive extracts of E. coli case studies in chemical and environmental. Engineering 3:100080. https://doi.org/10.1016/j.cscee.2021.100080
Marghoob MU, Noureen A, Raza A, Khan WS, Iftikhar M, Sher F (2021) Synthesis and toxicity assessment of environment friendly high yield ceria nanoparticles for biosafety. J Environ Chem Eng 10(1):107029. https://doi.org/10.1016/j.jece.2021.107029
Mashaghi S, Jadidi T, Koenderink G, Mashaghi A (2013) Lipid nanotechnology. Int J Mol Sci. https://doi.org/10.3390/ijms14024242
Mittal AK, Thanki K, Jain S, Banerjee UC (2016) Comparative studies of anticancer and antimicrobial potential of bioinspired silver and silver-selenium nanoparticles. Appl Nanomed 1:1–6
Mobaraki F, MomeniM YMET, Meshka Z, ToosiM S, Hosseini SM (2021) Plant-derived synthesis and characterization of gold nanoparticles: Investigation of its antioxidant and anticancer activity against human testicular embryonic carcinoma stem cells. Process Biochem 111:167–177. https://doi.org/10.1016/j.procbio.2021.09.010
Moghadamtousi SZ, Kamarudin MNA, Chan CK, Goh BH, Kadir HA (2014) Phytochemistry and biology of Loranthus parasiticus Merr, a commonly used herbal medicine. Am J Chin Med 42:23–35. https://doi.org/10.1142/S0192415X14500025
Mondal S, Bandyopadhyay S, Ghosh KM, Mukhopadhyay S, Roy S, Mandal C (2012) Natural products: promising resources for cancer drug discovery. Anti-Cancer Agents Med Chem (formerly Current Medicinal Chemistry-Anti-Cancer Agents) 12:49–75. https://doi.org/10.2174/187152012798764697
Mondal A, Gandhi A, Fimognari C, AtanasovAG BA (2019) Alkaloids for cancer prevention and therapy: current progress and future perspectives. Eur J Pharmacol 858:172472. https://doi.org/10.1016/j.ejphar.2019.172472
Montalbán MG, Coburn JM, Lozano-Pérez AA, CenisJL VG, Kaplan DL (2018) Production of curcumin-loaded silk fibroin nanoparticles for cancer therapy. Nanomaterials 8(2):126. https://doi.org/10.3390/nano8020126
Montané X, Kowalczyk O, Reig-Vano B, Bajek A, Roszkowski K, Tomczyk R, Tylkowski B (2020) Current perspectives of the applications of polyphenols and flavonoids in cancer therapy. Molecule 25:3342. https://doi.org/10.3390/molecules25153342
Murthy D, Attri KS, Singh PK (2018) Phosphoinositide 3-kinase signaling pathway in pancreatic ductal adenocarcinoma progression, pathogenesis, and therapeutics. Front Physiol 9:335. https://doi.org/10.3389/fphys.2018.00335
Nair A, Chauhan P, Saha B, Kubatzky KF (2019) Conceptual evolution of cell signaling. Int J Mol Sci 20:3292. https://doi.org/10.3390/ijms20133292
Narnoliya LK, Sangwan N, Jadaun JS, Bansal S, Sangwan RS (2021) Defining the role of a caffeic acid 3-O-methyltransferase from Azadirachta indica fruits in the biosynthesis of ferulic acid through heterologous over-expression in Ocimum species and Withania somnifera. Planta 253:20. https://doi.org/10.1007/s00425-020-03514-y
Oliveira CR, Spindola DG, Garcia DM, ErustesA BA, Palmeira-dos-Santos C, Smaili SS, Pereira GJ, Hinsberger A, Viriato EP (2019) Medicinal properties of Angelica archangelica root extract: cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development. J Integr Med 17:132–140. https://doi.org/10.1016/j.joim.2019.02.001
Palaniappan P, Sathishkumar G, Sankar R (2015) Fabrication of nano-silver particles using Cymodocea serrulata and its cytotoxicity effect against human lung cancer A549 cells line. Spectrochim Acta Part A Mol Biomol Spectrosc 138:885–890. https://doi.org/10.1016/j.saa.2014.10.072
Paramee S, Sookkhee S, Sakonwasun C, Takuathung MN, Mungkornasawakul P, Nimlamool W, Potikanond S (2018) Anti-cancer effects of Kaempferia parviflora on ovarian cancer SKOV3 cells. BMC Complement Altern Med 18:178. https://doi.org/10.1186/s12906-018-2241-6
Parveen R, Parveen B, Parveen A, Ahmad S (2019) Andrographis paniculata: from traditional to nano drug for cancer therapy. Nanomater Plant Potential. https://doi.org/10.1007/978-3-030-05569-1_13
Patra JK, Das G, Fraceto LF, Campos EVR, Rodriguez-Torres MDP, Acosta-Torres LS, Diaz-Torres LA, Grillo R, Swamy MK, Sharma S, Habtemariam S, Shin HS (2018) Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol 16(1):71. https://doi.org/10.1186/s12951-018-0392-8
Peppercorn J, Herndon J, Kornblith AB, Peters W, Ahles T, Vredenburgh J, Cancer and Leukemia Group B (CALGB), The Southwestern Oncology Group (SWOG) Group (2005) Quality of life among patients with Stage II and III breast carcinoma randomized to receive high-dose chemotherapy with autologous bone marrow support or intermediate-dose chemotherapy: results from Cancer and Leukemia Group B 9066. Cancer 104:1580–1589. https://doi.org/10.1002/cncr.21363
Priyadarshni and Mahalingam (2017) Antimicrobial and anticancer activity of silver nanoparticles from Edible Mushroom: a review. Asian J Pharmaceut Clin Res 10:37–40. https://doi.org/10.22159/ajpcr.2017.v10i3.16027
Rai M, Kon K, Ingle A, DuranN GS, Galdiero M (2014) Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects. Appl Microbiol Biotechnol 98:1951–1961. https://doi.org/10.1007/s00253-013-5473-x
Ramakanth GSH, Kumar CU, Kishan PV, Usharani P (2016) A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med 7(3):151–157. https://doi.org/10.1016/j.jaim.2016.05.003
Ramar M, Manikandan B, Marimuthu PN, Raman T, Mahalingam A, Subramanian P, KarthickS MA (2015) Synthesis of silver nanoparticles using Solanum trilobatumfruits extract and its antibacterial, cytotoxic activity against human breast cancer cell line MCF 7. Spectrochim Acta Part A Mol Biomol Spectrosc 140:223–228. https://doi.org/10.1016/j.saa.2014.12.060
Reddy P, Pradeep S, Gopinath SM, Ramu R, Kollur SP, Shivamallu C (2022) Anti-breast cancer potential of MnO2 nanoparticles using Terminalia chebula fruit extract against MCF-7 cell line through in vitro cell cycle and apoptotic studies. Mater Today Proc 62:5526
Ren B, Kwah MXY, Liu C, Ma Z, Shanmugam MK, Ding L, Goh BC (2021) Resveratrol for cancer therapy: challenges and future perspectives. Cancer Lett 515:63–72. https://doi.org/10.1016/j.canlet.2021.05.001
Saleem J, Wang L, Chen C (2018) Carbon-based nanomaterials for cancer therapy via targeting tumor microenvironment. Adv Healthc Mater 7:1800525. https://doi.org/10.1002/adhm.201800525
Sangwan NS, Sangwan RS (2014) Secondary metabolites of traditional medical plants – a case study Ashwaganda. In: Opatrný Z, Nick P (eds) Applied cell technology. Plant cell monographs. Springer, Germany, pp 325–367
Sangwan NS, Tripathi S, Srivastava Y, Mishra B, Pandey N (2017) Phytochemical genomics of Ashwagandha. Science of Ashwagandha: preventive and therapeutic potentials. Springer, Cham, pp 3–36
Sathiyavimal S, Durán-Lara EF, Vasantharaj S, Saravanan M, Sabour A, Alshiekheid M, Pugazhendhi A (2022) Green synthesis of copper oxide nanoparticles using Abutilon indicum leaves extract and their evaluation of antibacterial, anticancer in human A549 lung and MDA-MB-231 breast cancer cells. Food Chem Toxicol. https://doi.org/10.1016/j.fct.2022.113330
Sato D, Kondo S, Yazawa K, Mukudai Y, Li C, Kamatani T, Katsuta H, Yoshihama Y, Shirota T, Shintani S (2013) The potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on human oral squamous cell carcinoma cells. Mol Clin Oncol 1:105–111. https://doi.org/10.3892/mco.2012.14
Sharma VK, Sangwan NS (2022) Biotechnology applications in neurodegenerative diseases in biotechnology in healthcare: technologies and innovations. In: Barh D (ed) Biotechnology approaches in developing novel drug delivery systems, Biotechnology in Healthcare: Technologies and Innovations, vol 2
Sharma A, Goyal AK, Rath G (2018) Recent advances in metal nanoparticles in cancer therapy. J Drug Targ 26:617–632a. https://doi.org/10.1080/1061186X.2017.1400553
Sharma A, Kaur M, Katnoria JK, Nagpal AK (2018) Polyphenols in food: cancer prevention and apoptosis induction. Curr Med Chem 25:4740–4757b. https://doi.org/10.2174/0929867324666171006144208
Shirzad H, Taji F, Rafieian-Kopaei M (2011) Correlation between antioxidant activity of garlic extracts and WEHI-164 fibrosarcoma tumor growth in BALB/c mice. J Med Food 14:969–974. https://doi.org/10.1089/jmf.2011.1594
Siddique AA, Joshi P, Misra LN, Sangwan NS, Darokar MP (2014) 5,6-De-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from Withania somnifera L. Dunal leaves. Nat Product Res 28(6):392–398. https://doi.org/10.1080/14786419.2013.871545
Siegel RL, Miller KD, Jemal A (2020) Cancer statistics, 2020. CA Cancer J Clin. https://doi.org/10.3322/caac.21590
Sre PR, Reka M, Poovazhagi R, Kumar MA, Murugesan K (2015) Antibacterial and cytotoxic effect of biologically synthesized silver nanoparticles using aqueous root extract of Erythrina indicam. Spectrochim Acta Part A Mol Biomol Spectrosc 135:1137–1144. https://doi.org/10.1016/j.saa.2014.08.019
Srikrishna D, Sachsenmeier K (2021) We need to bring R0 < 1 to treat cancer too. Genome Med 13(1):120. https://doi.org/10.1186/s13073-021-00940-9
Srivastava Y, Sangwan NS (2020) Improving medicinal crops through phytochemical perspective: Withania somnifera (Ashwagandha). In: Tuteja N (ed) Advancement in crop improvement techniques. WoodHead Publishing, Sawston, pp 275–295. https://doi.org/10.1016/B978-0-12-818581-0.00017-6
Sultana S, Munir N, Mahmood Z, Riaz M, Akram M, Rebezov M, Rengasamy KR (2021) Molecular targets for the management of cancer using Curcuma longa Linn. phytoconstituents: a review. Biomed Pharmacother 135:111078. https://doi.org/10.1016/j.biopha.2020.111078
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. https://doi.org/10.3322/caac.21660
Tan J, Tay J, Hedrick J, Yang YY (2020) Synthetic macromolecules as therapeutics that overcome resistance in cancer and microbial infection. Biomaterials 252:120078. https://doi.org/10.1016/j.biomaterials.2020.120078
Thomson CA, Dickinson S, Bowden T (2010) Cruciferous vegetables, isothiocyanates, indoles, and cancer prevention. Nutrition and health: bioactive compounds and cancer. Springer, Berlin, pp 535–566
Tripathi D, Modi A, Narayan G, Rai SP (2019a) Green and cost effective synthesis of silver nanoparticles from endangered medicinal plant Withania coagulans and their potential biomedical properties. Mater Sci Eng C 100:152–164. https://doi.org/10.1016/j.msec.2019.02.113
Tripathi SK, Mahakud AK, Biswa BK (2019b) A green approach towards formulation, characterization, and antimicrobial activity of poly (Lactic-co-Glycolic) acid-Alstonia scholaris based nanoparticle. Mater Res Express 6(9):095325. https://doi.org/10.1088/2053-1591/ab30d1
Turan I, Demir S, Kilinc K, Burnaz NA, Yaman SO, Akbulut K, Mentese A, Aliyazicioglu Y, Deger O (2017) Antiproliferative and apoptotic effect of Morus nigra extract on human prostate cancer cells. Saudi Pharm J 25:241–248. https://doi.org/10.1016/j.jsps.2016.06.002
Vakayil R, Muruganantham S, Kabeerdass N, Rajendran M, Ramasamy S, Alahmadi TA, Mathanmohun M (2021) Acorus calamus-zinc oxide nanoparticle coated cotton fabrics shows antimicrobial and cytotoxic activities against skin cancer cells. Process Biochem 111:1–8. https://doi.org/10.15666/aeer/2002_919929
Valsalam ASP, Arasu MV, Al-Dhabi NA, Ghilan AM, Kaviyaras K, Ravindran B, Chang SW, Arokiyaraj S (2019) Rapid biosynthesis and characterization of silver nanoparticles from the leaf extract of Tropaeolum majus L. and its enhanced in-vitro antibacterial, antifungal, antioxidant and anticancer properties. J Photochem Photobiol B Biol 191:65–74. https://doi.org/10.1016/j.jphotobiol.2018.12.010
Wang N, Feng Y, Zhu M, Tsang CM, Man K, Tong Y, Tsao SW (2010) Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem 111:1426–1436. https://doi.org/10.1002/jcb.22869
Wang S, Zhong Z, Wan J, Tan W, Wu G, Chen M, Wang Y (2013) Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med 41:177–196. https://doi.org/10.1142/S0192415X13500134
Wang Y, Shen Y, Wang S, Shen Q, Zhou X (2018) The role of STAT3 in leading the crosstalk between human cancers and the immune system. Cancer Lett 415:117–128. https://doi.org/10.1016/j.canlet.2017.12.003
Wang N, Dheen ST, Fuh JYH, Kumar AS (2021a) A review of multi-functional ceramic nanoparticles in 3D printed bone tissue engineering. Bioprinting 23:e00146. https://doi.org/10.1016/j.bprint.2021.e00146
Wang T, SuitaY MS, Dean J, Tapinos N, Shen J (2021b) Advances in lipid-based nanoparticles for cancer chemoimmunotherapy. Pharmaceutics 13(4):520a. https://doi.org/10.3390/pharmaceutics13040520
Xia QH, Ma YJ, Wang JW (2016) Biosynthesis of silver nanoparticles using Taxus yunnanensis callus and their antibacterial activity and cytotoxicity in human cancer cells. Nanomaterials 6:160. https://doi.org/10.3390/nano6090160
Xia L, Tan S, Zhou Y, Lin J, Wang H, Oyang L, Tian Y, Liu L, Su M, Wang H, Cao D (2018) Role of the NFκB-signaling pathway in cancer. Onco Targets Ther 11:2063. https://doi.org/10.2147/OTT.S161109
Yadav N, Sangwan NS (2022) Biotechnology approaches in developing novel drug delivery systems. In: Barh D (ed) Elsevier Chapter 13: Biotechnology approaches in developing novel drug delivery systems. Biotechnology in Healthcare: Technologies and Innovations, vol 1
Yallapu MM, Jaggi M, Chauhan CS (2013) Curcumin nanomedicine: a road to cancer therapeutics. Curr Pharm Des 19:1994–2010. https://doi.org/10.2174/138161213805289219
Yang X, Yang Y, Tang S, Tang H, Yang G, Xu Q, Wu J (2014) Anti-tumor effect of polysaccharides from Scutellaria barbata D. Don on the 95-D xenograft model via inhibition of the C-met pathway. J Pharmacol Sci 125:255–263. https://doi.org/10.1254/jphs.13276fp
Yao Y, Dai W (2014) Genomic instability and cancer. J Carcinogenes Mutagenis. https://doi.org/10.4172/2157-2518.1000165
Yu JS, Kim AK (2010) Platycodin D induces apoptosis in MCF-7 human breast cancer cells. J Med Food 13:298–305. https://doi.org/10.1089/jmf.2009.1226
Zargar T, Kumar D, Sahni B, Shoket N, Bala K, Angurana S (2021) Dietary risk factors for colorectal cancer: A hospital-based case–control study. Cancer Res Stat Treatment 4(3):479. https://doi.org/10.4103/crst.crst_116_21
Zhang P, Li H, Yang B, Yang F, Zhan LL, Kong QY, Liu J (2014) Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells. Genes Cancer 5(5–6):154. https://doi.org/10.18632/genesandcancer.15
Zhang X, Xiong Y, Xia Q, Wu F, Liu L, Zhou Y, Zen L, Zhou C, Xia C, Jiang W, Liao XL, Liu L, Yang H, Guan R, Li K, Wang J, Lei G, Zhang Y, Yang N (2020) Efficacy and safety of apatinib plus vinorelbine in patients with wild-type advanced non-small cell lung cancer after second-line treatment failure: a nonrandomized clinical trial. JAMA Netw Open 3(3):e201226. https://doi.org/10.1001/jamanetworkopen.2020.1226
Zheng X, Li H, He Y, Yuan M, Shen M, Yang R, Yang C (2019) Preparation and in vitro release of total alkaloids from alstonia scholaris leaves loaded mPEG-PLA microspheres. Materials 12(9):1457. https://doi.org/10.3390/ma12091457
Zhu XY, Guo DW, Lao QC, Xu YQ, Meng ZK, Xia B, Yang H, Li CQ, Li P (2019) Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep 9:4541. https://doi.org/10.1038/s41598-019-40866-2
Zocchi L, Wu SC, Wu J, Hayama KL, Benavente CA (2018) The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells. Oncotarget 9:23505. https://doi.org/10.18632/oncotarget.25239
Acknowledgements
NY is thankful to UGC (536 CSIR-UGC NET DEC. 2018) for fellowship. NSS is thankful to DST for financial grant. The funding agency had no role in the interpretation or writing the manuscript.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors state that there are no conflicts of interest to disclose.
Rights and permissions
Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Yadav, N., Singh, D., Rawat, M. et al. Novel archetype in cancer therapeutics: exploring prospective of phytonanocarriers. 3 Biotech 12, 324 (2022). https://doi.org/10.1007/s13205-022-03372-3
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s13205-022-03372-3