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Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats

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Abstract

The present study was undertaken to evaluate the antidiabetic and hypolipidemic action of leaf extract of Barleria cristata Linn in rats. Diabetes was induced in the rats by a single intraperitoneal (IP) injection of alloxan (150 mg/kg) and randomly divided into 7 groups. Animals were treated with low (250 mg/kg) and high (500 mg/kg) doses of ethyl acetate leaf extract (EALE) and hydro-alcoholic leaf extract (HALE) up to 21 days. The body weight and blood glucose level (BGL) were measured on weekly basis. The rats were killed under mild ether anesthesia on 21st day, blood and the vital organ were collected to estimate biochemical parameters and to study histopathological changes. A single-dose administration of alloxan induced hyperglycemia in all the groups. A regular increase in BGL was observed in toxic control groups when compared with the normal control. Daily oral administration of rats with extracts (HALE and EALE) and standard drug (Glimepiride, 5 mg/kg), reduced elevated BGL significantly (p < 0.001), and body weight was regained in diabetic rats. The extract treatment also improved the normal functioning of the liver and kidneys as evidenced by the restoration of the biochemical profile. The study revealed that B. cristata possesses promising antidiabetic and hypolipidemic activity.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia

    Mohd Nazam Ansari & Abdulaziz S. Saeedan

  2. Department of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India

    Sakshi Bajaj & Lakhveer Singh

Authors
  1. Mohd Nazam Ansari
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  2. Abdulaziz S. Saeedan
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  3. Sakshi Bajaj
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  4. Lakhveer Singh
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Contributions

We declare that this work was done by the author(s) named in this article. MNA, ASS, SB and LS designed the study. SB and LS did experimental work. MNA and ASS collected and analyzed the data. MNA wrote the manuscript with support from ASS, SB and LS. All the authors read and approved the manuscript for publication.

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Correspondence to Mohd Nazam Ansari.

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Ansari, M.N., Saeedan, A.S., Bajaj, S. et al. Evaluation of antidiabetic and hypolipidemic activity of Barleria cristata Linn. leaves in alloxan-induced diabetic rats. 3 Biotech 11, 170 (2021). https://doi.org/10.1007/s13205-021-02728-5

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