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Phytosynthesized nanoparticles as a potential cancer therapeutic agent

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Abstract

Plants are the well-known sources for the hyper-accumulation and reduction of metallic ions. Analysis of various plant extracts has justified the presence of different types of phytochemicals that possess the stabilization and reduction functionalities of precursors to form nanoparticles. Such characteristics make plants as an attractive source for synthesizing eco-friendly nanoparticles (NPs) with potentially less toxicity to the body. Recently, phytosynthesized nanoparticles have been explored for targeted inhibition and diagnosis of cancer cells without affecting non-cancerous healthy cells. The aim of this review is to discuss the characteristic performance of NPs synthesized from various plant sources for the diagnosis and inhibition of cancer. The mode of action of phytosynthesized nanoparticles for anti-cancer applications are also discussed.

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Acknowledgements

The author (Dr. Jaison Jeevanandam) acknowledge the support of FCT-Fundação para a Ciência e a Tecnologia (Base Fund UIDB/00674/2020 and Programmatic Fund UIDP/00674/2020, Portuguese Government Funds), ARDITI-Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação through the project M1420-01-0145-FEDER-000005-CQM+ (Madeira 14-20 Program). All the authors would like to thank their respective departments for the support provided during the preparation of this article.

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105, Funchal, Portugal

    Jaison Jeevanandam

  2. Department of Chemistry and Biomolecular Science, University of Ottawa, Ottawa, ON, K1N6N5, Canada

    Prabir Kumar Kulabhusan

  3. Chemical Engineering Department, University of Tennessee, Chattanooga, TN, 37403, USA

    Godfred Sabbih & Michael K. Danquah

  4. Department of Eastern Medicine, Government College University, Faisalabad, 38000, Pakistan

    Muhammad Akram

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  1. Jaison Jeevanandam
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  2. Prabir Kumar Kulabhusan
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  3. Godfred Sabbih
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  4. Muhammad Akram
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  5. Michael K. Danquah
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Contributions

JJ drafted the content, compiled and corrected all the sections. PKK, MA and GS contributed each section in the manuscript and MKD reviewed the final version of the manuscript to ensure technical coherence. All authors read and approved the final version of the manuscript.

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Correspondence to Michael K. Danquah.

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Jeevanandam, J., Kulabhusan, P.K., Sabbih, G. et al. Phytosynthesized nanoparticles as a potential cancer therapeutic agent. 3 Biotech 10, 535 (2020). https://doi.org/10.1007/s13205-020-02516-7

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