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Endophytic fungi isolated from Brazilian medicinal plants as potential producers of antioxidants and their relations with anti-inflammatory activity

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Abstract

In this study, 19 endophytic fungi were isolated from Lafoensia pacari, Guazuma ulmifolia, Campomanesia xanthocarpa and Siparuna guianensis. Seventeen strains were molecularly identified as belonging to the genera Colletotrichum, Diaporthe, Bjerkandera, Talaromyces, Cochliobolus, Phaeophlebiopsis, Curvularia, and Xylaraceae. Assays for detecting antioxidant activity were performed by free radical scavenging activity using the DDPH and ABTS + methods. Based on the results with DPPH, two strains were selected to evaluate the presence of flavonoids and anti-inflammatory activity. A strong positive correlation was found between these activities and the presence of flavonoids. The anti-inflammatory activity of endophytic fungi is under explored; however, the Talaromyces obtained the best result of 87.33% protection of erythrocytes and Colletotrichium of 60.71%. This study demonstrated that endophytic fungi associated with selected plants are potential sources of novel antioxidant products.

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Acknowledgements

This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001.

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Authors and Affiliations

  1. Laboratory of Environmental Microbiology, Department of Biology, Federal University of São Carlos, Rodovia João Leme dos Santos Km 110, Sorocaba, SP, 18052-780, Brazil

    Tamara Fonseca Bastos Santos, Cleoni dos Santos Carvalho, Mônica Aparecida de Almeida, Tiago Palladino Delforno & Iolanda Cristina Silveira Duarte

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  1. Tamara Fonseca Bastos Santos
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  2. Cleoni dos Santos Carvalho
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  3. Mônica Aparecida de Almeida
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Correspondence to Iolanda Cristina Silveira Duarte.

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Santos, T.F.B., dos Santos Carvalho, C., de Almeida, M.A. et al. Endophytic fungi isolated from Brazilian medicinal plants as potential producers of antioxidants and their relations with anti-inflammatory activity. 3 Biotech 10, 223 (2020). https://doi.org/10.1007/s13205-020-02211-7

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