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An efficient deep eutectic magnetic nano gel for rapid ultrasound-assisted dispersive µ-solid phase extraction of residue of tetracyclines in food samples

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Abstract

In the present study, a magnetic nano gel as the sorbent which is the combination of octatonic acid: cumarin as eutectic solvent and Fe3O4@SiO2 was introduced as the sorbent in ultrasound-assisted dispersive µ-solid phase extraction process coupled with high performance liquid chromatography with photo diode array detector for simultaneous separation and determination of tetracyclines residues in food samples. FT-IR, SEM, VSM were used for the characterization of the synthetized magnetic nano gel. Under obtained optimum conditions, the obtained linear ranges were 1.5–500 (µg L−1), 2.5–750 (µg L−1), 2–750 (µg L−1), and 2.5–500 (µg L−1) for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. Moreover, the below level of quantification (BLQ) (based on S/N = 3) of 0.47 µg L−1, 0.11 µg L−1, 0.85 µg L−1, 0.66 µg L−1, 0.81 µg L−1 and the limit of quantification (based on S/N = 10) of 1.61, 2.74, 2.23 (µg L−1), and 2.66 were achieved for tetracycline, oxytetracycline, chlortetracycline, and doxycycline, respectively. The intra-day and inter-day precision (%) of the procedure were less than 3.2 and 3.8, respectively. The recoveries over 95% confirmed high sufficiency of the proposed method for application in complex matrices such as honey, milk, and egg.

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Funding

This research has been supported by the University of Jiroft under Grant No. 3813–1400–1.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, University of Jiroft, P. O. Box 7867161167, Jiroft, Iran

    Mahboube Shirani

  2. Research Group of Food, Halal and Agricultural Products, Research Department of Food Technology and Agricultural Products, Standard Research Institute (SRI), P.O. Box 31745-139, Karaj, Iran

    Mohammad Faraji

  3. Department of Food Science and Technology, Faculty of Food Industry and Agriculture, Standard Research Institute, Karaj, Iran

    Hamid Rashidi Nodeh

  4. Food and Drug Laboratory Research Center, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Islamic Republic of Iran

    Behrouz Akbari-adergani

  5. Laboratories of Food and Drug Control, Vice Chancellery for Food and Drug, Isfahan University of Medical Sciences, Isfahan, Iran

    Soheila Sepahi

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  1. Mahboube Shirani
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  4. Behrouz Akbari-adergani
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MS Investigation, writing-original draft, conceptualization, methodology, MF, HRN, BA-a Conceptualization, Editing, SS conceptualization, methodology.

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Correspondence to Mahboube Shirani.

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Shirani, M., Faraji, M., Rashidi Nodeh, H. et al. An efficient deep eutectic magnetic nano gel for rapid ultrasound-assisted dispersive µ-solid phase extraction of residue of tetracyclines in food samples. J Food Sci Technol 60, 2802–2812 (2023). https://doi.org/10.1007/s13197-023-05798-w

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