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Synchronous/Metachronous Bilateral Breast Cancer: a Long-Term Follow-up Single-Center Experience

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Abstract

We aimed to evaluate the ratio of bilateral breast cancer (BBC) to breast cancer and to compare the clinicopathological characteristics, treatment, and results of synchronous bilateral breast cancer (sBBC) and metachronous bilateral breast cancer (mBBC) with long-term follow-up. Patients with breast cancer (BC) who were treated consecutively between 2009 and 2019, included on accrual records, were examined. We determined the time interval for the development of two tumors to be detected within 6 months for the definition of synchronous tumors. In total, of the 2198 patients diagnosed with BC, 76 had BBC. Our BBC rate was 3.4%. The median age of tumor detection was 56 for sBBC and 51 for mBBC. As a result of the 5-year disease-free survival (DFS) analysis, the mean survival times of sBBC and mBBC were found to be 41 months and 60 months, respectively (p = 0.006). As a result of the 5-year overall survival (OS) analysis, the OS in sBBC and mBBC was 44 months and 60 months, respectively, and the difference in mean survival times between the groups was statistically significant (p = 0.001). The difference between the sBBC and mBBC groups was statistically significant for both DFS and OS, based on 10-year survival (p = 0.004 and p = 0.001, respectively). In this study conducted at a single center, disease-free survival and overall survival were worse in sBBC than in mBBC.

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Data Availability

All data generated or analyzed during this study are included in this published article. But restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of University of Health Sciences Istanbul Training and Research Hospital.

References

  1. Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660

    Article  PubMed  Google Scholar 

  2. Sim Y, Tan VKM, Sidek NAB et al (2018) Bilateral breast cancers in an Asian population, and a comparison between synchronous and metachronous tumours. ANZ J Surg 88(10):982–987. https://doi.org/10.1111/ans.14773

    Article  PubMed  Google Scholar 

  3. Sakai T, Ozkurt E, DeSantis S et al (2019) National trends of synchronous bilateral breast cancer incidence in the United States. Breast Cancer Res Treat 178(1):161–167. https://doi.org/10.1007/s10549-019-05363-0

    Article  PubMed  Google Scholar 

  4. Jobsen JJ, van der Palen J, Ong F et al (2015) Bilateral breast cancer, synchronous and metachronous; differences and outcome. Breast Cancer Res Treat 153(2):277–283. https://doi.org/10.1007/s10549-015-3538-5

    Article  CAS  PubMed  Google Scholar 

  5. Malone KE, Daling JR, Weiss NS et al (1996) Family history and survival of young women with invasive breast carcinoma. Cancer 78(7):1417–1425. https://doi.org/10.1002/(SICI)1097-0142(19961001)78:7%3c1417:AID-CNCR7%3e3.0.CO;2-H

    Article  CAS  PubMed  Google Scholar 

  6. Díaz R, Munárriz B, Santaballa A et al (2012) Synchronous and metachronous bilateral breast cancer: a long-term single-institution experience. Med Oncol (Northwood, London, England) 29(1):16–24. https://doi.org/10.1007/s12032-010-9785-8

    Article  Google Scholar 

  7. Jiang H, Zhang R, Liu X et al (2021) Bilateral breast cancer in China: a 10-year single-center retrospective study (2006–2016). Cancer Med 10(17):6089–6098. https://doi.org/10.1002/cam4.4141

    Article  PubMed  PubMed Central  Google Scholar 

  8. Liang X, Li D, Geng W et al (2013) The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients. Tumour Biol 34(2):995–1004. https://doi.org/10.1007/s13277-012-0636-4

    Article  CAS  PubMed  Google Scholar 

  9. Wadasadawala T, Lewis S, Parmar V et al (2018) Bilateral breast cancer after multimodality treatment: a report of clinical outcomes in an Asian population. Clin Breast Cancer 18(4):e727–e737. https://doi.org/10.1016/j.clbc.2017.11.003

    Article  PubMed  Google Scholar 

  10. Mishra S, Sable M, Das Majumdar SK et al (2022) Bilateral breast cancer-its clinicopathological profile and management: an experience from a tertiary care center from Eastern India. J Cancer Res Ther 18(Supplement):S341–S346. https://doi.org/10.4103/jcrt.JCRT_1729_20

    Article  PubMed  Google Scholar 

  11. Hong C, Zheng Y, Geng R et al (2022) Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data. Ann Transl Med 10(13):742. https://doi.org/10.21037/atm-21-5400

  12. Ozturk A, Alco G, Sarsenov D et al (2018) Synchronous and metachronous bilateral breast cancer: a long-term experience. J BUON 23(6):1591–1600

    PubMed  Google Scholar 

  13. Pan BO, Xu Y, Zhou YD et al (2019) The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: a meta-analysis of studies from recent decade (2008–2018). Cancer Med 8(6):2908–2918. https://doi.org/10.1002/cam4.2198

    Article  PubMed  PubMed Central  Google Scholar 

  14. Sarveazad A, Babahajian A, Shamseddin J, Bahardoust M (2018) 5‐year survival rates and prognostic factors in patients with synchronus and metachronus breast cancer from 2010 to 2015. Asian Pac J Cancer Prev 19(12):3489–3493. https://doi.org/10.31557/APJCP.2018.19.12.3489

  15. Jacob LA, Anand A, Lakshmaiah KC et al (2018) Clinicopathological profile and treatment outcomes of bilateral breast cancer: a study from tertiary cancer center in South India. Indian J Med Paediatr Oncol 39(1):58–61. https://doi.org/10.4103/ijmpo.ijmpo_56_17

    Article  Google Scholar 

  16. O’Brien JA, Ho A, Wright GP et al (2015) Breast-conserving surgery in bilateral breast cancer. Ann Surg Oncol 22(10):3389–3396. https://doi.org/10.1245/s10434-015-4746-2

    Article  PubMed  PubMed Central  Google Scholar 

  17. Kim H, Lee H, Choi DH et al (2022) Distribution of tumor subtypes in bilateral breast cancer: comparison between synchronous and metachronous cancer. Asia-Pac J Clin Oncol 18(1):28–34. https://doi.org/10.1111/ajco.13444

    Article  PubMed  Google Scholar 

  18. Huang KL, Liu YL, Hsu YY, Kuo WL (2021) Retrospective analysis of clinicopathological features and familial cancer history of synchronous bilateral breast cancer. Healthcare (Basel) 9(9):1203. https://doi.org/10.3390/healthcare9091203

    Article  PubMed  Google Scholar 

  19. Kheirelseid EA, Jumustafa H, Miller N et al (2011) Bilateral breast cancer: analysis of incidence, outcome, survival and disease characteristics. Breast Cancer Res Treat 126(1):131–140. https://doi.org/10.1007/s10549-010-1057-y

    Article  PubMed  Google Scholar 

  20. Gong SJ, Rha SY, Jeung HC et al (2007) Bilateral breast cancer: differential diagnosis using histological and biological parameters. Jpn J Clin Oncol 37(7):487–492. https://doi.org/10.1093/jjco/hym056

    Article  PubMed  Google Scholar 

  21. Qiu R, Zhao W, Yang J et al (2019) Comparative analysis of outcomes and clinicopathological characteristics of synchronous and metachronous contralateral breast cancer: a study of the SEER database. J Breast Cancer 22(2):297–310. https://doi.org/10.4048/jbc.2019.22.e18

    Article  PubMed  PubMed Central  Google Scholar 

  22. Huber A, Seidler SJ, Huber DE (2020) Clinicopathological characteristics, treatment and outcome of 123 patients with synchronous or metachronous bilateral breast cancer in a Swiss institutional retrospective series. Eur J Breast Health 16(2):129–136. https://doi.org/10.5152/ejbh.2020.5297

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Ozlem Mermut & Berrin Yalcın

  2. Department of Medical Oncology, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Rıza Umar Gürsu

  3. Department of General Surgery, Bahçeşehir University Hospital, Istanbul, Turkey

    Didem Can Trabulus

  4. Department of General Surgery, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Fatih Dal

  5. Department of Pathology, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Esra Canan Kelten Talu

  6. Department of Nuclear Medicine, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Esra Arslan

  7. Department of Radiology, University of Health Sciences Istanbul Training and Research Hospital, Istanbul, Turkey

    Emine Sevcan Ata

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  1. Ozlem Mermut
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Correspondence to Ozlem Mermut.

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Ethics Approval

All procedures performed in this study, involving human participants, were in accordance with the ethical standards of the İnstitutional Research Committee and 1964 Helsinki Declaration. Local ethics committee approval was obtained from University of Health Sciences Istanbul Training and Research Hospital (Date: 30/07/2021, Decision no: 2895).

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Mermut, O., Yalcın, B., Gürsu, R.U. et al. Synchronous/Metachronous Bilateral Breast Cancer: a Long-Term Follow-up Single-Center Experience. Indian J Surg (2023). https://doi.org/10.1007/s12262-023-03965-z

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