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Patients’ Survival with Astrocytoma After Treatment: a Systematic Review and Meta-analysis of Clinical Trial Studies

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Abstract

About half of the brain tumours are primary and the rest are metastatic. The impact of each of these treatments alone or together on the prognosis of patients with astrocytoma tumours, especially low-grade astrocytoma, is unclear which may pose many challenges in the decision-making of surgeons and patients. Considering the importance of patient’s outcomes with astrocytoma and lack of general statistics, this study aimed to determine the survival of patients with high-grade astrocytoma and low-grade astrocytoma after treatments. This study follows a systematic review and a meta-analysis approach. Following a systematic review and meta-analysis method, articles dated from 1982 to March 2020 were extracted from Embase, ScienceDirect, Scopus, PubMed and Web of Science (WoS) international databases. Random effects model was used for analysis, and heterogeneity of studies was investigated considering the I2 index. Data were analysed using the Comprehensive Meta-Analysis software (version 2). According to a meta-analysis of studies, the mean overall survival in patients with high-grade astrocytoma was 31.9 ± 2.7 months, for 2-year survival, 38.1% (95% CI: 27.5–50.1%) and for 5-year survival was 28.6% (95% CI: 24.1–33.4%). Mean overall survival in patients with low-grade astrocytoma was 64.8 ± 7.4 months, for 2-year survival was 74.3% (95% CI: 32.6–94.5%) and for 5-year survival was 74.4% (95% CI: 57.9–86%). The highest mean for survival in patients with high-grade astrocytoma and in chemotherapy and radiation therapy treatments was 45.2 ± 5.2 months, and also the highest mean for survival in patients with low-grade astrocytoma in surgical treatment was 71.4 ± 8.8 months. The results of this study show that the average survival in patients with low-grade astrocytoma is high following the treatment, and in high-grade astrocytoma, there will be the highest survival rate, if the surgical treatment is combined with chemotherapy and radiation therapy. This study summarizes retrospective studies up to 2020 to evaluate the prognosis and survival of patients with brain astrocytoma tumours, and the results of this meta-analysis can be of interest to surgeons and specialists in this field.

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Data availability

Datasets are available through the corresponding author upon reasonable request.

Abbreviations

CNS:

Central nervous system

CONSORT:

Consolidated Standards of Reporting Trials

PRISMA:

Preferred Reporting Items for Systematic Reviews and Meta-Analysis

WoS:

Web of Science

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Acknowledgements

The authors thank the Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Funding

The research funding was supported by the student research committee of Kermanshah University of Medical Sciences, grant no. 990652.

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Authors and Affiliations

  1. Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Nader Salari

  2. Department of Neurosurgery, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Reza Fatahian

  3. Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mohsen Kazeminia

  4. Department of Business Systems & Operations, University of Northampton, Northampton, UK

    Amin Hosseinian-Far

  5. Department of Biology, Faculty of Science, University Putra Malaysia, Serdang, Selangor, Malaysia

    Shamarina Shohaimi

  6. Cellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash , Iran

    Masoud Mohammadi

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  1. Nader Salari
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  3. Mohsen Kazeminia
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Contributions

RF, NS and MK contributed to the design, and MM participated in statistical analysis and most of the study steps. MM, AHF and SHSH prepared the manuscript. MM, MK and NS assisted in designing the study, and helped in the interpretation of the study. All authors have read and approved the content of the manuscript.

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Correspondence to Masoud Mohammadi.

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Ethics approval was received from the ethics committee of deputy of research and technology, Kermanshah University of Medical Sciences (IR.KUMS.REC.1399.652).

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The authors declare no competing interests.

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Salari, N., Fatahian, R., Kazeminia, M. et al. Patients’ Survival with Astrocytoma After Treatment: a Systematic Review and Meta-analysis of Clinical Trial Studies. Indian J Surg Oncol 13, 329–342 (2022). https://doi.org/10.1007/s13193-022-01533-7

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