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Tumor budding as a prognostic indicator in colorectal carcinoma: a retrospective study of primary colorectal carcinoma cases in a tertiary care center

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Abstract

Colorectal carcinoma (CRC) is the third most common cancer worldwide. Along with many established prognostic factors, tumor budding is emerging as a valuable marker of prognosis. Tumor budding is not yet universally reported but it has recently been suggested in guidelines by ITBCC (International Tumor Budding Consensus Conference). Our aim is to study prognostic implications of tumor budding in CRC. Hundred cases of primary CRC specimens were retrospectively studied from January, 2016, to February, 2017. Tumor bud count and other histopathological parameters were evaluated from hematoxyline and eosin (H & E) stained slides. Survival analysis was done using Cox proportional hazards model. Association of tumor budding and cancer-specific survival was found to be statistically significant (P = 0.018 for average tumor budding and P = 0.035 for highest tumor budding) Tumor budding was found to be significantly associated with other clinicopathological parameters such as T stage, N stage, TNM stage, and lymphovascular invasion with p value < 0.05. Tumor budding is a valuable prognostic indictor for primary CRC and also significantly associated with other prognostic parameters. It should be reported routinely as a guide to prognosis and further management of patients.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

We thank technical staff for their help and community oncology department for their guidance in statistical analysis.

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Authors and Affiliations

  1. Department of Oncopathology, Gujarat Cancer and Research Institute, Ahmedabad, 380016, Gujarat, India

    Ashini H. Shah, Amisha J. Gami, Neetal H. Desai, Jahnavi S. Gandhi & Priti P. Trivedi

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  1. Ashini H. Shah
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  2. Amisha J. Gami
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  3. Neetal H. Desai
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Contributions

Ashini Shah and Neetal Desai performed study concept, design, and development of methodology as well as writing and review of the article. Amisha Gami performed development of methodology, writing, and review of the article. Jahnavi Gandhi and Priti Trivedi performed review and revision of the article. All authors approved the final paper.

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Correspondence to Ashini H. Shah.

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Subject ontology

Tumor budding, Colorectal carcinoma, Survival.

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Shah, A.H., Gami, A.J., Desai, N.H. et al. Tumor budding as a prognostic indicator in colorectal carcinoma: a retrospective study of primary colorectal carcinoma cases in a tertiary care center. Indian J Surg Oncol 13, 459–467 (2022). https://doi.org/10.1007/s13193-022-01498-7

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  • DOI: https://doi.org/10.1007/s13193-022-01498-7

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