Abstract
Cancer-associated deep venous thrombosis (DVT) and venous thromboembolism (VTE) are exceedingly common in patients with cancer. One-fifth of DVT events occur in patients with cancer and it is the second leading cause of death in patients with cancer after cancer itself. Data on DVT in cancer patients on medical therapy, especially from Indian experiences, are sparse. Here, we present our experience in ambulatory patients with solid organ cancer. The purpose of the study was to study the incidence of DVT in cancer patients on medical therapy and to analyze probable DVT risk factors. This study was a hospital-based single-arm retrospective collection and analysis of hospital records from patients receiving medical therapy on an outpatient and short-stay basis. From January 2016 to February 2017, adult solid organ cancer patients attending the medical oncology outpatient department (OPD), receiving active anticancer treatment, either oral or injectable, were included. The data was retrieved from the medical records department and the department of radiology. Descriptive statistics were used to analyze the data. Twenty-nine out of 1190 patients were documented to have developed DVT during the study period. The incidence of DVT in the outpatient settings was 2.4%, and DVT associated with venous access device in situ was seen in 4.05% (20/493) of the patients. Gynecological, breast, and hepatobiliary malignancies comprised most of the cases. Cancer patients are clearly at increased risk for DVT, but this risk is highly variable. It differs between subgroups of cancer patients. Five points Khorana risk model can predict risk for DVT in the ambulatory cancer patients receiving chemotherapy; however, the routine use of thromboprophylaxis in all cancer patients is not recommended. High-risk patients especially those with venous access devices need careful evaluation and counseling for prompt reporting and recognition of venous thrombosis.
Similar content being viewed by others
Data Availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Gao S, Escalante C (2004) Venous thromboembolism and malignancy. Expert Rev Anticancer Ther 4:303–320
Khorana AA (2009) Cancer and thrombosis: implications of published guidelines for clinical practice. Ann Oncol 20:1619–1630
Moser KM, Fedullo PF, LitteJohn JK, Crawford R (1994) Frequent asymptomatic pulmonary embolism in patients with deep venous thrombosis. JAMA 271(3):223–225
Stein PD, Henry JW (1995) Prevalence of acute pulmonary embolism among patients in a general hospital and at autopsy. Chest 108:978–981
Palareti G (2012) Recurrent venous thromboembolism: what is the risk and how to prevent it. Scientifica (Cairo) 2012:391734
Connolly GC, Khorana AA (2010) Emerging risk stratification approaches to cancer-associated thrombosis: risk factors, biomarkers and a risk score. Thromb Res 125(Suppl 2):S1–S7
Jakhetiya A, Shukla NK, Deo SV, Garg PK, Thulkar S (2016) Deep vein thrombosis in Indian cancer patients undergoing major thoracic and abdomino-pelvic surgery. Indian J Surg Oncol 7(4):425–429
Nair CK, Bhattacharjee A, Raghavan V, Babu S, Balasubramanian S (2015) Impact of thrombosis on standard treatment in solid tumors. Thromb Res 136(5):943–946
Sawant SP, Banumathy S, Daddi A, Dhir AA (2012) Pulmonary embolism in cancer patients. Indian J Cancer 49(1):119–124
Khorana AA, Dalal M, Tangirala K, Miao R (2011) Higher incidence of venous thromboembolism in the outpatient versus the inpatient setting among U.S. cancer patients[abstract]. Blood 118:Abstract 674
Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW (2008) Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood 111(10):4902–4907
Murray J, Precious E, Alikhan R (2013) Catheter-related thrombosis in cancer patients. Br J Haematol 162(6):748–757
Chopra V, Anand S, Hickner A, Buist M, Rogers MA, Saint S et al (2013) Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis. Lancet 382(9889):311–325
Sundriyal D, Shirsi N, Kapoor R, Jain S, Mittal G, Khivasara J et al (2014) Peripherally inserted central catheters: our experience from a cancer research centre. Indian J Surg Oncol 5(4):274–277
Code Availability
Not applicable.
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. Data collection and analysis were performed by AS, AC, and DG. The manuscript was written by DS, AS, GSM, and AC. Manuscript review and editing was done by AS, DG, and DS. All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Ethics Approval
Approved by the Institutional Ethics Committee.
Consent to Participate
Not applicable for record based retrospective studies and waived off.
Consent for Publication
No individual person’s data contained in the publication.
Conflict of Interest
The authors declare no conflict of interest.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Sehrawat, A., Mittal, G.S., Sundriyal, D. et al. Cancer-Associated Venous Thromboembolism in Ambulatory Solid Organ Malignancy Patients: Experience from a Cancer Research Institute. Indian J Surg Oncol 12, 246–250 (2021). https://doi.org/10.1007/s13193-021-01303-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-021-01303-x