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Pattern of Venous Thrombosis in Cancer Patients: Frequency and Survival Effect; Single Center Experience

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Venous thromboembolism (VTE) represents one of the most important causes of morbidity and mortality in cancer patients. This investigation was undertaken to investigate the natural history of VTE in the oncology center in a tertiary care hospital. We did a retrospective study on cancer patients who presented to King Abdullah Medical city in Holly capital; a tertiary care hospital; from May 2011 to June 2013. Follow up period was calculated from time of VTE diagnosis till the last clinical visit or till patient death. Among 1,678 cancer patients, 132 (7.87 %) were diagnosed with VTE. The median patient age was 53.5 years, with female to male ratio 1.3/1. Thirty one patients (23.5 %) were diagnosed with VTE and cancer simultaneously, seventy four patients (56.1 %) were on chemotherapy and twenty eight patients (21.2 %) were on best supportive care.VTE were symptomatic in 110 patients (83.3 %) and asymptomatic in 22 patients (16.7 %). Lower limbs were the commonest site (42.4 %) with the highest incidence in patients with advanced stages (93 %). Forty nine (37 %) patients were receiving LMWH as prophylaxis. Median survival in months for patients with VTE prophylaxis versus without prophylactic, and asymptomatic versus symptomatic were (12.6 vs 6.3; p 0.12 and 9.8 vs 12.4; p 0.885, respectively). There is underutilization of thromboprophylaxis in our region, which needs more effort to reduce VTE burden. Also we need large prospective studies to clarify the impact of VTE symptoms and presentation on patient’s survival.

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Ethical Consideration

Ethical approval to conduct the study was taken from the IRB review committee before the commencement of the study.

Conflict of Interest

The authors certify that is no potential or actual conflict of interest related to this research.

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Authors and Affiliations

  1. Oncology Center, King Abdullah Medical City, Muzdallifa Street, P.O. Box 57657, Holy Capital, 21995, Saudi Arabia

    Amrallah A. Mohammed, Abdullah S. Al-Zahrani, Hafez M. Ghanem & Hani M. EL-Khatib

  2. Medical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Amrallah A. Mohammed

  3. Strategic Planning Department, King Abdullah Medical City, Holy Capital, Saudi Arabia

    Mian U. Farooq

  4. Clinical Oncology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

    Lobna A. Abdelaziz

Authors
  1. Amrallah A. Mohammed
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  2. Abdullah S. Al-Zahrani
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  3. Mian U. Farooq
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  4. Hafez M. Ghanem
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  5. Lobna A. Abdelaziz
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  6. Hani M. EL-Khatib
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Correspondence to Amrallah A. Mohammed.

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Mohammed, A.A., Al-Zahrani, A.S., Farooq, M.U. et al. Pattern of Venous Thrombosis in Cancer Patients: Frequency and Survival Effect; Single Center Experience. Indian J Hematol Blood Transfus 31, 439–445 (2015). https://doi.org/10.1007/s12288-014-0496-8

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  • DOI: https://doi.org/10.1007/s12288-014-0496-8

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