Skip to main content

Advertisement

SpringerLink
Log in

Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET

  • Original Article
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).

Methods

We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50–70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.

Results

The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).

Conclusions

We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimer’s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013;12:207–16.

    Article  CAS  Google Scholar 

  2. Sabri O, Seibyl J, Rowe C, Barthel H. Beta-amyloid imaging with florbetaben. Clin Transl Imaging. 2015;3:13–26.

    Article  Google Scholar 

  3. Landau SM. Optimizing longitudinal amyloid-β PET measurement: the challenges of intensity normalization. J Nucl Med. 2018;59:1581–2.

    Article  CAS  Google Scholar 

  4. Tuszynski T, Rullmann M, Luthardt J, Butzke D, Tiepolt S, Gertz H, et al. Evaluation of software tools for automated identification of neuroanatomical structures in quantitative β-amyloid PET imaging to diagnose Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 2016;43:1077–87.

    Article  CAS  Google Scholar 

  5. Veronese M, Bodini B, García-Lorenzo D, Battaglini M, Bongarzone S, Comtat C, et al. Quantification of C-11 PIB PET for imaging myelin in the human brain: a test—retest reproducibility study in high-resolution research tomography. J Cereb Blood Flow Metab. 2015;35:1771–82.

    Article  Google Scholar 

  6. Barthel H, Senda M, Luthardt J, Strick A, Yamane T, Patt M, et al. Influence of ethnic group, age, gender, and tracer mass dose on florbetaben β-amyloid brain PET results in elderly normal controls. Alzheimers Dement. 2010;6:S436.

    Article  Google Scholar 

  7. Um YH, Choi WH, Jung WS, Park YH, Lee C, Lim HK. Whole brain voxel-wise analysis of cerebral retention of Beta-amyloid in cognitively normal older adults using 18F-florbetaben. Psychiatry Investig. 2017;14:883.

    Article  Google Scholar 

  8. Alzheimer’s Association. 2018 Alzheimer’s disease facts and figures. Alzheimers Dement. 2018;14:367–429.

    Article  Google Scholar 

  9. Ampil ER, Fook-Chong S, Sodagar SN, Chen CPH, Auchus AP. Ethnic variability in dementia: results from Singapore. Alzheimer Dis Assoc Disord. 2005;19:184–5.

    Article  Google Scholar 

  10. Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, et al. Amyloid-β associated cortical thinning in clinically normal elderly. Ann Neurol. 2011;69:1032–42.

    Article  CAS  Google Scholar 

  11. Presotto L, Laccarino L, Sala A, Vanoli EG, Muscio C, Nigri A, et al. Low-dose CT for the spatial normalization of PET images: a validation procedure for amyloid-PET semi-quantification. NeuroImage Clin. 2018;20:153–60.

    Article  Google Scholar 

  12. Barthel H, Gertz H, Dresel S, Peters O, Bartenstein P, Buerger K, et al. Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer’s disease and healthy controls: a multicentre phase 2 diagnostic study. Lancet Neurol. 2011;10:424–35.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors are grateful to Dr. Yoon for the assistance with data arrangement and Prof. Yumi Kim for the comments on the statistical analysis.

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, 26 Daesingongwon-ro, Seo-gu, Busan, 602-715, South Korea

    Jieun Jeong, Young Jin Jeong & Do-Young Kang

  2. Institute of Convergence Bio-Health, Dong-A University, Busan, South Korea

    Jieun Jeong, Young Jin Jeong, Kyung Won Park & Do-Young Kang

  3. Department of Neurology, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, South Korea

    Kyung Won Park

Authors
  1. Jieun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Young Jin Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kyung Won Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Do-Young Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Do-Young Kang.

Ethics declarations

Conflict of Interest

Jieun Jeong, Yong Jin Jeong, Kyung Won Park, and Do-Young Kang declare that they have no conflict of interest. This research was supported by the project at Institute of Convergence Bio-Health, DongA University, funded by Busan Institute of S&T Evaluation and Planning.

Ethical Statement

This study was performed in accordance with the ethical standards laid down in the Helsinki Declaration of 1964 and its later revisions.

Informed Consent

Informed consent was obtained from all individual participants included in this prospective study.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jeong, J., Jeong, Y.J., Park, K.W. et al. Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET. Nucl Med Mol Imaging 53, 334–339 (2019). https://doi.org/10.1007/s13139-019-00609-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-019-00609-7

Keywords

Search

Navigation