Skip to main content
SpringerLink
Log in

Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography

  • Original Article
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Objective

A recently introduced single-photon emission computed tomography (SPECT), based on cadmium-zinc-telluride (CZT) detectors (D-SPECT), supports high energy resolution for cardiac imaging. Importantly, the high energy resolution may allow simultaneous dual-isotope (SDI) imaging (e.g., using Tc-99m and I-123). We quantitatively evaluated Tc-99m/I-123 SDI imaging by D-SPECT in comparison with conventional T1-201/I-123.

Materials and Methods

Energy resolution was measured as a percentage of the full width at half maximum (FWHM) for Tc-99m, I-123, and Tl-201. The impact of cross-talk and reconstructed image contrast were quantified by measuring the contrast-to-noise ratio (CNR), and the transmural defect contrast in the left ventricle wall (CTD) induced by a difference in energy, for combinations of Tc-99m/I-123 or Tl-201/I-123, using an RH-2 cardiac phantom. Corresponding measurement was also carried out in Anger SPECT (A-SPECT).

Results

The energy resolution of the D-SPECT system was 5.4%/5.1% for Tc-99m/I-123 and 5.4%/5.3% for Tl-201/I-123, which was approximately two times higher than the A-SPECT. No notable difference was confirmed in the CNRs of the two systems, but T1-201/I-123 showed overall higher value than Tc-99m/I-123. Compared to A-SPECT, CTD of D-SPECT significantly increased with both Tc-99m/I-123 and T1-201/I-123 (p < 0.05). In DSPECT, the combination of Tc-99m/I-123 had a slightly better CTD than T1-201/I-123. In addition, CTD of Tc-99m/I-123 was improved with scatter correction at both nuclides (p < 0.05), but in Tl-201/I-123, no significant improvement was confirmed in I-123 (p > 0.05).

Conclusion

D-SPECT was considered to be capable of performing high-quality SDI imaging using Tc-99m/I-123.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: new designs and clinical implications. J Nucl Med. 2011;52:210–7.

    Article  PubMed  Google Scholar 

  2. Neill J, Prvulovich EM, Fish MB, Berman DS, Slomka PJ, Sharir T, et al. Initial multicenter experience of high-speed myocardial perfusion imaging: comparison between high-speed and conventional single-photon emission computed tomography with angiographic validation. Eur J Nucl Med Mol Imaging. 2013;40:1084–94.

    Article  PubMed  CAS  Google Scholar 

  3. Duvall WL, Slomka PJ, Gerlach JR, Sweeny JM, Baber U, Croft LB, et al. High-efficiency SPECT MPI: comparison of automated quantification, visual interpretation, and coronary angiography. J Nucl Cardiol. 2013;20:763–73.

    Article  PubMed  Google Scholar 

  4. Ben-Haim S, Kacperski K, Hain S, Van Gramberg D, Hutton BF, Erlandsson K, et al. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging. 2010;37:1710–21.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ko T, Utanohara Y, Suzuki Y, Kurihara M, Iguchi N, Umemura J, et al. A preliminary feasibility study of simultaneous dual-isotope imaging with a solid-state dedicated cardiac camera for evaluating myocardial perfusion and fatty acid metabolism. Heart Vessel. 2016;31:38–45.

    Article  Google Scholar 

  6. Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, et al. Simultaneous acquisition of (99m)Tc- and (123)I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors. Ann Nucl Med. 2016;30:263–71.

    Article  PubMed  CAS  Google Scholar 

  7. Blaire T, Bailliez A, Bouallegue FB, Bellevre D, Agostini D, Manrique A. Left ventricular function assessment using 123I/99mTc dual-isotope acquisition with two semi-conductor cadmium–zinc–telluride (CZT) cameras: a gated cardiac phantom study. EJNMMI Phys. 2016;3:27–37.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Berger HJ, Gottschalk A, Zaret BL. Dual radionuclide study of acute myocardial infarction: comparison of thallium-201 and technetium-99m stannous prophosphate imaging in man. Ann Intern Med. 1978;88:145–54.

    Article  PubMed  CAS  Google Scholar 

  9. Tsuji A, Kojima A, Matsumoto M, Oyama Y, Tomiguchi S, Kira T, et al. A new method for crosstalk correction in simultaneous dual-isotope myocardial imaging with Tl-201 and I-123. Ann Nucl Med. 1999;13:317–23.

    Article  PubMed  CAS  Google Scholar 

  10. Nakajima K, Shimizu K, Taki J, Uetani Y, Konishi S, Tonami N, et al. Utility of iodine-123-BMIPP in the diagnosis and follow-up of vasospastic angina. J NucI Med. 1995;36:1934–40.

    CAS  Google Scholar 

  11. Yamagishi H, Akioka K, Shirai N, Yoshiyama M, Teragaki M, Takeuchi K, et al. Effects of smoking on myocardial injury in patients with conservatively treated acute myocardial infarction—a study with resting 123I-15-iodophenyl 3-methyl pentadecanoic acid/201Tl myocardial single photon emission computed tomography. Jpn Circ J. 2001;65:769–74.

    Article  PubMed  CAS  Google Scholar 

  12. Einstein AJ, Moser KW, Thompson RC, Cerqueira MD, Henzlova MJ. Radiation dose to patients from cardiac diagnostic imaging. Circulation. 2007;116:1290–305.

    Article  PubMed  Google Scholar 

  13. Einstein AJ, Pascual TNB, Mercuri M, Karthikeyan G, Vitola JV, Mahmarian JJ, et al. Current worldwide nuclear cardiology practices and radiation exposure: results from the 65 country IAEA Nuclear Cardiology Protocols Cross-Sectional Study (INCAPS). Eur Heart J. 2015;36:1689–96.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Gambhir SS, Berman DS, Ziffer J, Nagler M, Sandler M, Patton J, et al. A novel high-sensitivity rapid-acquisition single-photon cardiac imaging camera. J Nucl Med. 2009;50:635–43.

    Article  PubMed  Google Scholar 

  15. Erlandsson K, Kacperski K, van Gramberg D, Hutton BF. Performance evaluation of D-SPECT: a novel SPECT system for nuclear cardiology. Phys Med Biol. 2009;54:2635–49.

    Article  PubMed  Google Scholar 

  16. Verger A, Imbert L, Yagdigul Y, Fay R, Djaballah W, Rouzet F, et al. Factors affecting the myocardial activity acquired during exercise SPECT with a high-sensitivity cardiac CZT camera as compared with conventional Anger camera. Eur J Nucl Med Mol Imaging. 2014;41:522–8.

    Article  PubMed  Google Scholar 

  17. Park MA, Moore SC, Muller SP, McQuaid SJ, Kijewski MF. Performance of a high-sensitivity dedicated cardiac SPECT scanner for striatal uptake quantification in the brain based on analysis of projection data. Med Phys. 2013;40:042504.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kacperski K, Erlandsson K, Ben-Haim S, Hutton BF. Iterative deconvolution of simultaneous 99mTc and 201Tl projection data measured on a CdZnTe-based cardiac SPECT scanner. Phys Med Biol. 2011;56:1397–414.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Niimi T, Sugimoto M, Nanasato M, Maeda H. Evaluation of cadmium-zinc-telluride detector-based single-photon emission computed tomography for nuclear cardiology: a comparison with conventional Anger single-photon emission computed tomography. Nucl Med Mol Imaging. 2017;51:331–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Esquerre JP, Coca FJ, Martinez SJ, Guiraud RF. Prone decubitus: a solution to inferior wall attenuation in thallium-201 myocardial tomography. J Nucl Med. 1989;30:398–401.

    PubMed  CAS  Google Scholar 

  21. Zoccarato O, Lizio D, Savi A, Indovina L, Scabbio C, Leva L, et al. Comparative analysis of cadmium-zincum-telluride cameras dedicated to myocardial perfusion SPECT: a phantom study. J Nucl Cardiol. 2016;23:885–93.

    Article  PubMed  Google Scholar 

  22. Kadrmas DJ, Frey EC, Tsui BMW. Simultaneous technetium-99m/thallium-201 SPECT imaging with model-based compensation for cross-contaminating effects. Phys Med Biol. 1999;44:1843–60.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  23. Nakazato R, Berman DS, Hayes SW, Fish M, Padgett R, Xu Y, et al. Myocardial perfusion imaging with a solid-state camera: simulation of a very low dose imaging protocol. J Nucl Med. 2013;54:373–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to acknowledge the assistance, support, and advice of the engineers of Spectrum Dynamics and the staff of Biosensors Japan. They also acknowledge the advice of M. Sugumi and the EIZO Corporation for the measurements of contrast-to-noise ratio, and the transmural defect contrast in the left ventricle wall.

Author information

Authors and Affiliations

  1. Department of Radiological Technology, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650, Japan

    Takanaga Niimi & Mitsuo Sugimoto

  2. Cardiovascular Center, Nagoya Daini Red Cross Hospital, 2-9 Myouken-cho, Showa-ku, Nagoya, 466-8650, Japan

    Mamoru Nanasato

  3. Department of Radiological Technology, Nagoya University School of Health Sciences, 1-1-20 Daiko-minami, Higashi-ku, Nagoya, 461-8673, Japan

    Hisatoshi Maeda

Authors
  1. Takanaga Niimi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mamoru Nanasato
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mitsuo Sugimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hisatoshi Maeda
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takanaga Niimi.

Ethics declarations

Conflict of Interest

Takanaga Niimi, Mamoru Nanasato, Mitsuo Sugimoto, and Hisatoshi Maeda declare that they have no conflict of interest.

Ethical Approval

This study was approved by the institutional review board of the hospital on October 25, 2016 and has been performed in accordance with the ethical standards laid down in the Helsinki Declaration of 1964 and later revision.

Informed Consent

All subjects in the study gave written informed consent or the institutional review board waived the need to obtain informed consent.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Niimi, T., Nanasato, M., Sugimoto, M. et al. Comparative Cardiac Phantom Study Using Tc-99m/I-123 and Tl-201/I-123 Tracers with Cadmium-Zinc-Telluride Detector-Based Single-Photon Emission Computed Tomography. Nucl Med Mol Imaging 53, 57–63 (2019). https://doi.org/10.1007/s13139-018-0559-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-018-0559-0

Keywords

Search

Navigation