Skip to main content

Advertisement

Log in

Prediction of pulmonary function after lobectomy

  • Research Clinical Study
  • Published:
Hellenic Journal of Surgery

Abstract

Aim-Background

Lung cancer is the most common cause of cancer death in both men and women in our country. It has been estimated that there will be 7,000 lung cancer deaths every year in Greece. However, many patients with bronchogenic carcinoma also have coexistent obstructive lung disease. In these patients, preoperative prediction of functional status after lung resection is mandatory. The aim of our study was to determine the effect of lobectomy on postoperative spirometric lung function.

Methods

Seventy-two patients underwent spirometric pulmonary tests preoperatively, and at three and six months after surgery. The predicted postoperative forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were calculated using the following formula suggested by Juhl and Frost.

Results

The functional percentage loss at six months for lobectomies was 7.34% for FVC and 7.72% for FEV1 respectively. The linear regression analysis derived from the correlation between predicted and measured FEV1 revealed the following equation: FEV 1 POSTOP = 0.00211+0.896660 X FEV 1 PREOP.

Conclusions

We conclude that our formula is a reliable method for predicting postoperative respiratory function of the patients with lung cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012; 62:10–29

    Article  PubMed  Google Scholar 

  2. Jemal A, Bray F, Center M, Ferlay J, Ward E, Forman D. Cancer Global statistics. CA Cancer J Clin 2011; 61:69–90

    Article  PubMed  Google Scholar 

  3. Bray F, Weiderpass E. Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970–2007. IJC 2010; 126:1454–1466

    CAS  Google Scholar 

  4. Malvezzi M, Bosetti C, Rosso T, Bertuccio P, Chatenoud L, Levi F, et al. Lung cancer mortality in European men: Trends and predictions. Lung Cancer 2013; 80:138–145

    Article  PubMed  Google Scholar 

  5. Beckles MA, Spiro SG, Colice GL, Rudd RM; American College of Chest Physicians. The physiologic evaluation of patients with lung cancer being considered for resectional surgery. Chest 2003; 123(Suppl 1):105–114

    Article  Google Scholar 

  6. Lim E, Baldwin D, Beckles MA, Duffy J, Entwisle J, Faivre-Finn C, et al. Guidelines on the radical management of patients with lung cancer. Thorax 2010; 65(Suppl 3):1–27

    Google Scholar 

  7. Schipper H, Clinch J, McMurray A, Levitt M. Measuring the quality of life of cancer patients: the Functional Living Index-Cancer: development and validation. J Clin Oncol 1984; 2:472–483

    CAS  PubMed  Google Scholar 

  8. De Leyn P, Lardinois D, Van Schil PE, Rami-Porta R, Passlick B, Zielinski M et al. ESTS guidelines for preoperative lymph node staging for non-small cell lung cancer. Eur J Cardiothorac Surg 2007; 32:1–8

    Article  PubMed  Google Scholar 

  9. Goldstraw P. The 7th Edition of TNM for Lung and Pleural Tumours. J Clin Anal Med 2012; 3:123–127

    Article  Google Scholar 

  10. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J 2005; 26:319–338

    Article  CAS  PubMed  Google Scholar 

  11. ATS/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med 2003; 167:211–277

  12. Juhl B, Frost N. A comparison between measured and calculated changes in the lung function after operation for pulmonary cancer. Acta Anaesth Scand 1975; 57(Suppl):39–45

    Article  CAS  Google Scholar 

  13. David EA, Marshall MB. Physiologic Evaluation of Lung Resection Candidates. Thor Surg Clin 2012; 22:47–54

    Article  Google Scholar 

  14. Alberts M. Introduction to the Third Edition: Diagnosis and Management of Lung Cancer (3rd ed.): ACCP Evidence-Based Clinical Practice Guidelines Chest 2013; 143(Suppl 5):38–40

    Google Scholar 

  15. Nikolouzos S. Complications after major pulmonary resec tions for lung cancer. A prospective study. Tesis; Postgraduate course (Msc) in Thoracic Oncology. National and Kapodestrian University of Athens, Medical School. 2013:1–130

    Google Scholar 

  16. Mazzone P. Preoperative evaluation of the lung resection candidate. Cleveland Clinic Journal of Medicine, 2012; 79(e-Suppl1):17–22

    Google Scholar 

  17. Armstrong P, Congleton J, Fountain SW, Jagoe T, McAuley DF, MacMahon J, et al. BTS guidelines on the selection of patients with lung cancer for surgery. Thorax 2001; 56:89–108

    Google Scholar 

  18. Shapiro M, Swanson SJ, Wright CD, Chin C, Sheng S, Wisnivesky J, et al. Predictors of major morbidity and mortality after pneumonectomy utilizing the Society for Thoracic Surgeons General Thoracic Surgery Database. Ann Thorac Surg 2010; 90:927–935

    Article  PubMed  Google Scholar 

  19. Solli P, Leo F, Veronesi G, Curigliano G, Martinoni A, Spaggiari L, et al. Impact of limited pulmonary function on the management of resectable lung cancer. Lung Cancer 2003; 41:71–79

    Article  PubMed  Google Scholar 

  20. Cetindag IB, Olson W, Hazelrigg SR. Acute and chronic reduction of pulmonary function after lung surgery. Thorac Surg Clin 2004; (14):317–323

    Article  PubMed  Google Scholar 

  21. Caglar M, Kara M, Aksoy T, Kiratli PO, Karabulut E, Dogan R. Is the predicted postoperative FEV1 estimated by planar lung perfusion scintigraphy accurate in patients undergoing pulmonary resection? Comparison of two processing methods. Ann Nucl Med 2010; 24:447–453

    Article  PubMed  Google Scholar 

  22. Yamashita CM, Langridge J, Hergott CA, Inculet RI, Malthaner RA, Lefcoe MS, et al. Predicting Postoperative FEV1 Using Spiral Computed Tomography. Academic Radiology 2010; 17:607–613

    Article  PubMed  Google Scholar 

  23. Mineo TC, Schillaci O, Pompeo E, Mineo D, Simonetti G. Usefulness of lung perfusion scintigraphy before lung cancer resection in patients with ventilatory obstruction. Ann Thorac Surg 2006; 82:1828–1834

    Article  PubMed  Google Scholar 

  24. Mariano-Goulart D, Barbotte E, Basurko C, Comte F, Rossi M. Accuracy and precision of perfusion lung scintigraphy versus 133Xe-radiospirometry for preoperative pulmonary functional assessment of patients with lung cancer. Eur J Nucl Med Molec Imag 2006; 33:1048–1054

    Article  Google Scholar 

  25. Zeicher BG, Gross TJ, Kern JA, Lanza LA, Peterson MW. Predicting postoperative pulmonary function in patients undergoing lung resection. Chest 1995; 108:68–72

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Nikolouzos.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Baltayiannis, N., Nikolouzos, S., Anagnostopoulos, D. et al. Prediction of pulmonary function after lobectomy. Hellenic J Surg 86, 159–165 (2014). https://doi.org/10.1007/s13126-014-0119-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13126-014-0119-8

Key words

Navigation