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Forced vital capacity predicts long-term survival for curative-resected NSCLC

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Abstract

We conducted a retrospective study in patients with non-small cell lung cancer (NSCLC) who underwent curative lung resection to seek for better lung function parameters associated with long-term survival after lung resection. From January 2006 to December 2008, 470 patients who underwent lung resection with a postoperative diagnosis of NSCLC were studied. Median survival time was 60 months. Patients with pulmonary function values <80 % of predicted were defined as lung function impairment. Patients with impaired vital capacity, maximal voluntary ventilation, forced vital capacity (FVC), forced expiratory volume in one second (FEV1) or diffusion capacity for carbon monoxide (DLCO) had significant shorter overall survival time (P = 0.024; P = 0.026; P < 0.001; P = 0.027; P = 0.007). In univariate analysis, VC, FVC, FEV1 and DLCO were found to have significant effect on overall survival. In multivariate analysis, FVC (HR, 2.029; 95 % CI 1.126–3.659; P = 0.019) was found to be an independent prognostic predictor of long-term overall survival. For cancer-specific survival, FVC (HR 2.404; 95 % CI 1.300–4.445; P = 0.005) was also found to be an independent prognostic predictor in multivariable analysis. Preoperative FVC, rather than FEV1 or DLCO, is an independent prognostic predictor for long-term survival. FVC is not only an indicator of lung function but also of great value for surgeons to predict survival after lung resection.

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Abbreviations

NSCLC:

Non-small cell lung cancer

VC:

Vital capacity

MVV:

Maximal voluntary ventilation

FVC:

Forced vital capacity

FEV1:

Forced expiratory volume in one second

PEF:

Peak expiratory flow

MMEF:

Maximum mid-expiratory flow

DLCO:

Diffusion capacity for carbon monoxide

RV/TLC:

Residual volume/total lung capacity

MST:

Median survival time

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Acknowledgments

The work was supported by Provincial Science and Technology Development Planning of Shandong (2011GGH21819) and Provincial Science and Technology Development Planning of Shandong (2012G0021836).

Conflict of interest

None of the authors declared Conflicts of Interest Statement of the article titled “Forced vital capacity is an independent prognostic predictor of long-term survival for curative resected NSCLC”.

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Authors and Affiliations

  1. Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, People’s Republic of China

    Xi Guo, Hongxin Cao, Jun Xu, Jianyu Yu, Chunlong Zheng & Jiajun Du

  2. Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, 250021, People’s Republic of China

    Long Meng & Jiajun Du

  3. Department of Critical Care Medicine, Qilu Hospital of Shandong University (Qingdao), Qingdao, Shandong, People’s Republic of China

    Xi Guo

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  1. Xi Guo
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  2. Hongxin Cao
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  3. Jun Xu
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  4. Jianyu Yu
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  5. Chunlong Zheng
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Correspondence to Long Meng or Jiajun Du.

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Xi Guo and Hongxin Cao have contributed equally to this work.

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Guo, X., Cao, H., Xu, J. et al. Forced vital capacity predicts long-term survival for curative-resected NSCLC. Med Oncol 31, 146 (2014). https://doi.org/10.1007/s12032-014-0146-x

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  • DOI: https://doi.org/10.1007/s12032-014-0146-x

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