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CuO-NPs/TFA: a New Catalytic System to Synthesize a Novel Series of Pyrazole Imines with High Antioxidant Properties

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Abstract

We report here the synthesis of a novel series of pyrazole analogs involving the condensation reaction between 5-amino-1H-pyrazole-4-carbonitrile derivatives and carbonyl compounds. The reactions proceeded in acidic media, and were catalyzed by copper oxide nanoparticles (CuO- NPs) which were synthesized under green condition. The tea leaves extract served as green reducing agent for the conversion of copper nitrate to CuO-NPs. The developed methodology afforded the desired products up to 90% yields in 6 h. The newly synthesized compounds were tested for antioxidant properties. Out of 15 newly developed pyrazole compounds, 11 showed better antioxidant activity than the standard antioxidant drug Trolox.

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Acknowledgements

Hanan Elnagdy thanks ICCR, New Delhi, for a fellowship. DS is thankful to DST, New Delhi, India, for a research grant [No. EMR/2016/002345].

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  1. Department of Chemistry, Dibrugarh University, Dibrugarh, 786004, Assam, India

    Hanan Mohamed Fathy Elnagdy, Nishi Gandha Gogoi, Jyotirekha G. Handique & Diganta Sarma

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  1. Hanan Mohamed Fathy Elnagdy
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  2. Nishi Gandha Gogoi
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  3. Jyotirekha G. Handique
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Correspondence to Diganta Sarma.

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12668_2021_888_MOESM1_ESM.docx

Supplementary file1 The spectra analysis of all synthesized pyrazole compounds is included in the supplementary information document. (DOCX 4310 KB)

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Elnagdy, H.M.F., Gogoi, N.G., Handique, J.G. et al. CuO-NPs/TFA: a New Catalytic System to Synthesize a Novel Series of Pyrazole Imines with High Antioxidant Properties. BioNanoSci. 11, 929–938 (2021). https://doi.org/10.1007/s12668-021-00888-5

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