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Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease

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Abstract

Chronic obstructive pulmonary disease (COPD) is associated with cognitive decline, but the molecular link between COPD and dementia or Alzheimer’s disease (AD) remains unclear. This study was aimed to investigate whether serum Aβ levels are correlated with COPD. 77 cognitively normal COPD patients and 45 age- and gender-matched normal controls were admitted to the study. Serum Aβ40 and Aβ42 levels were measured using ELISA kits. Serum C-reactive protein (CRP), interleukin 6 (IL-6), and procalcitonin (PCT) measurements were done using standard laboratory methods. Pulmonary function tests were performed to assess the pulmonary function and determine the degree of lung damage. Significantly increased levels of serum Aβ40, Aβ42, and total Aβ levels were found in patients with COPD in comparison with normal controls. In COPD patients, serum Aβ levels were higher in subjects with serum CRP, IL-6, and PCT upper the limit of normal. Moreover, serum Aβ levels were dramatically higher in COPD patients with worse pulmonary function. Our study suggests that cognitively normal COPD patients may undergo AD-related pathological changes, and COPD might facilitate AD-type pathogenesis.

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Acknowledgments

This study was supported by National Natural Science Foundation of China (Grant Nos. 81270423 and 81471296).

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    Authors and Affiliations

    1. Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China

      Xian-Le Bu, Lin-Lin Shen, Yang Xiang, Shu-Sheng Jiao, Yu-Hui Liu, Chi Zhu, Fan Zeng, Qing-Hua Wang, Ye-Ran Wang, Hua-Dong Zhou & Yan-Jiang Wang

    2. Department of Respiratory Medicine, Daping Hospital, Third Military Medical University, 10 Changjiang Branch Road, Yuzhong District, Chongqing, China

      Guo-Qiang Cao & Yong He

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    1. Xian-Le Bu
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    Correspondence to Yan-Jiang Wang.

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    Xian-Le Bu and Guo-Qiang Cao have contributed equally to this work.

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    Bu, XL., Cao, GQ., Shen, LL. et al. Serum Amyloid-Beta Levels are Increased in Patients with Chronic Obstructive Pulmonary Disease. Neurotox Res 28, 346–351 (2015). https://doi.org/10.1007/s12640-015-9552-x

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    • DOI: https://doi.org/10.1007/s12640-015-9552-x

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