Abstract
Objectives
Low concentrations of serum 25-hydroxyvitamin D [25(OH)D] have been postulated to associate with an increased prevalence of depression. As there are a limited number of publications on this issue, we examined the association between serum 25(OH)D and depression in a general middle-aged or older population.
Design
A population-based cross-sectional study.
Setting and participants
A total of 1602 men and women from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD) in Eastern Finland, aged 53-73 y in 1998-2001, were analysed.
Measurements
Depressive symptoms were assessed with the DSM-III depression scale, and those individuals who had scores over 4 (range 0-12) or had reported undergoing current antidepressant therapy, were considered as suffering from depression. Associations were estimated in serum 25(OH)D tertiles using logistic regression.
Results
Among the participants, 183 subjects (11.4%) were considered to have depression. The mean age of the subjects was 62.6 years (SD 6.4, range 53.4- 73.8 years). The mean serum 25(OH)D concentration was 43.8 nmol/L (SD 17.7, range 8.5-112.8 nmol/L), concentrations <50 nmol/L were observed in 65.0% of the subjects, and only 5.0% displayed concentrations ≥75 nmol/L. After multivariable adjustments, the odds ratios for having depression in the tertiles (from highest to the lowest) of serum 25(OH)D were 1, 1.35 (95 % CI: 0.87, 2.09) and 1.64 (95 % CI: 1.03, 2.59), P for trend=0.036.
Conclusion
These findings indicate that a lower concentration of serum 25(OH)D is associated with a higher prevalence of depression in an elderly general population.
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References
Norman AW, Bouillon R. Vitamin D nutritional policy needs a vision for the future. Exp Biol Med 2010;235:1034–1045.
Lamberg-Allardt C, Brustad M, Meyer HE, Steingrimsdottir L. Vitamin D – a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations. Food Nutr Res 2013;57:22671.
Bonham MP, Lamberg-Allardt C. Vitamin D in public health nutrition. Public Health Nutr 2014;17:717–720.
Littlejohns TJ, Kos K, Henley WE, Kuzma E, Llewellyn DJ. Vitamin D and dementia. J Prev Alz Dis 2016;3:43–52.
Anglin RES, Samaan Z, Walter SD, McDonald SD. Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 2013;202:100–107.
Milaneschi Y, Hoogendijk W, Lips P, Heijboer AC, Schoevers R, van Hemert AM, et al. The association between low vitamin D and depressive disorders. Mol Psychiatry 2014;19:444–451.
Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266–281.
Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr 2008;87:1080S-6S.
Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr 2008;88:491S-9S.
Jääskeläinen T, Knekt P, Suvisaari J, Männistö S, Partonen T, Sääksjärvi K, et al. Higher serum 25-hydroxyvitamin D concentrations are related to a reduced risk of depression. Brit J Nutr 2015;113:1418–26.
Lee DM, Tajar A, O’Neil TW, O´Connor DB, Bartfai G, Boonen S, et al. Lower vitamin D levels are associated with depression among community-dwelling European men. J Psychopharmacol 2011;25:1320–1328.
Chung HK, Cho Y, Choi S, Shin MJ. The association between serum 25-hydroxyvitamin D concentrations and depressive symptoms in Korean adults: findings from the fifth Korea National Health and Nutrition Examination Survey 2010. PLoS One 2014;9:e99185.
Pan A, Lu L, Franco OH, Yu Z, Li H, Lin X. Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese. J Affect Disord 2009;118:240–243.
Zhao G, Ford ES, Li C, Balluz LS. No associations between serum concentration of 25-hydroxyvitamin D and parathyroid hormone and depression among US adults. Brit J of Nutr 2010;104:1696–1702.
Imai CM, Halldorsson TI, Eiriksdottir G, Cotch MF, Steingrimsdottir L, Thorsdottir I, et al. Depression and serum 25-hydroxyvitamin D in older adults living at northern latitudes -AGES-Reykjavik Study. J Nutr Sci. 2015;20;4:e37.
Gallagher JC. Vitamin D and aging. Endocrinol Metab Clin North Am. 2013;42(2):319–32.
Salonen JT, Nyyssönen K, Korpela H, Tuomilehto J, Seppänen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 1992;86:803–811.
Lynch JW, Kaplan GA, Cohen RD, Kauhanen J, Wilson TW, Smith NL, et al. Childhood and adulthood socioeconomic status as predictors of mortality in Finland. Lancet 1994;343:524–527.
Laaksonen DE, Lakka TA, Lakka HM, Nyyssönen K, Rissanen T, Niskanen LK, et al. Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men. Diabet Med 2002;19:456–464.
Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction in men. N Engl J Med 1994;330:1549–1554.
Trevisan C, Veronese N, Berton L, Carraro S, Bolzetta F, De Rui M, et al. Factors influencing serum-hydroxivitamin D levels and other bone metabolism parameters in healthy older women. J Nutr Health Aging. 2017;21:131–135.
Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. Low dietary folate intake is associated with an excess incidence of acute coronary events: the Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001;103:2674–2680.
Virtanen JK, Nurmi T, Voutilainen S, Mursu J, Tuomainen TP. Association of serum 25-hydroxyvitamin D with the risk of death in a general older population in Finland. Eur J Nutr 2011;50:305–312.
Oliver JM, Simmons ME. Depression as measured by the DSM-III and the Beck Depression Inventory in an unselected adult population. J Consult Clin Psychol 1984;52:892–898.
Altman DG, Bland JM. Quartiles, quintiles, centiles and other quantiles. BMJ 1994;309:996.
Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1a-hydroxylase in human brain. J Chem Neuroanat 2005;29:21–30.
Bertone-Johnson ER. Vitamin D and the occurrence of depression: causal association or circumstantial evidence? Nutr Rev 2009;67:481–492.
Wang T-T, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, et al. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol 2005;19:2685–2695.
Belmaker RH, Agam G. Major depressive disorder. N Engl J Med 2008;358:55–68.
Obradovic D, Gronemeyer H, Lutz B, Rein T. Cross-talk of vitamin D and glucocorticoids in hippocampal cells. J Neurochem 2006;96:500–509.
Berk M, Williams LJ, Jacka FN, O’Neil A, Pasco JA, Moylan S, et al. So depression is an inflammatory disease, but where does the inflammation come from? BMC Medicine 2013;11:200–215.
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Vidgren, M., Virtanen, J.K., Tolmunen, T. et al. Serum Concentrations of 25-Hydroxyvitamin D and Depression in a General Middle-Aged to Elderly Population in Finland. J Nutr Health Aging 22, 159–164 (2018). https://doi.org/10.1007/s12603-017-0948-6
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DOI: https://doi.org/10.1007/s12603-017-0948-6