Skip to main content

Advertisement

SpringerLink
Log in

A Next-Generation Bacteria (Akkermansia muciniphila BAA-835) Presents Probiotic Potential Against Ovalbumin-Induced Food Allergy in Mice

  • Research
  • Published:
Probiotics and Antimicrobial Proteins Aims and scope Submit manuscript

Abstract

Next-generation microorganisms have recently gained prominence in the scientific community, mainly due to their probiotic and postbiotic potentials. However, there are few studies that investigate these potentials in food allergy models. Therefore, the present study was designed to evaluate the probiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy (OVA) model and also analyse possible postbiotic potential. To access the probiotic potential, clinical, immunological, microbiological, and histological parameters were evaluated. In addition, the postbiotic potential was also evaluated by immunological parameters. Treatment with viable A. muciniphila was able to mitigate weight loss and serum levels of IgE and IgG1 anti-OVA in allergic mice. In addition, the ability of the bacteria to reduce the injury of the proximal jejunum, the eosinophil and neutrophil influx, and the levels of eotaxin-1, CXCL1/KC, IL4, IL6, IL9, IL13, IL17, and TNF, was clear. Furthermore, A. muciniphila was able to attenuate dysbiotic signs of food allergy by mitigating Staphylococcus levels and yeast frequency in the gut microbiota. In addition, the administration of the inactivated bacteria attenuated the levels of IgE anti-OVA and eosinophils, indicating its postbiotic effect. Our data demonstrate for the first time that the oral administration of viable and inactivated A. muciniphila BAA-835 promotes a systemic immunomodulatory protective effect in an in vivo model of food allergy to ovalbumin, which suggests its probiotic and postbiotic properties.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

Availability of Data and Material

The datasets generated and analysed during the current study are available from the corresponding author upon reasonable request.

Code Availability

Not applicable.

References

  1. Turnbull JL, Adams HN, Gorard DA (2015) The diagnosis and management of food allergy and food intolerances. Aliment Pharmacol Ther 41:3–25. https://doi.org/10.1111/apt.12984

    Article  CAS  PubMed  Google Scholar 

  2. Matsui T, Tanaka K, Yamashita H, Saneyasu KI, Tanaka H, Takasato Y, Sugiura S, Inagaki N, Ito K (2019) Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency. Allergol Int 68:172–177. https://doi.org/10.1016/j.alit.2018.12.003

    Article  CAS  PubMed  Google Scholar 

  3. Aitoro R, Paparo L, Amoroso A, Di Costanzo M, Cosenza L, Granata V, Di Scala C, Nocerino R, Trinchese G, Montella M, Ercolini D, Berni Canani R (2017) Gut microbiota as a target for preventive and therapeutic intervention against food allergy. Nutrients 9:672. https://doi.org/10.3390/nu9070672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sharma G, Im SH (2018) Probiotics as a potential immunomodulating pharmabiotics in allergic diseases: current status and future prospects. Allergy, Asthma Immunol Res 10:575–590. https://doi.org/10.4168/aair.2018.10.6.575

    Article  CAS  PubMed  Google Scholar 

  5. Chernikova DA, Zhao MY, Jacobs JP (2022) Microbiome therapeutics for food allergy. Nutrients 14:5155. https://doi.org/10.3390/nu14235155

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ (2014) Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 20:159–166. https://doi.org/10.1038/nm.3444

    Article  CAS  PubMed  Google Scholar 

  7. Tan J, McKenzie C, Vuillermin PJ, Goverse G, Vinuesa CG, Mebius RE, Macia L, Mackay CR (2016) Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways. Cell Rep 15:2809–2824. https://doi.org/10.1016/j.celrep.2016.05.047

    Article  CAS  PubMed  Google Scholar 

  8. Castellazzi AM, Valsecchi C, Caimmi S, Licari A, Marseglia A, Leoni MC, Caimmi D, Del Giudice MM, Leonardi S, Rosa ML, Marseglia GL (2013) Probiotics and food allergy. Ital J Pediatr 39:1–10. https://doi.org/10.1186/1824-7288-39-47

    Article  CAS  Google Scholar 

  9. Kim H, Kwack K, Kim DY, Ji GE (2005) Oral probiotic bacterial administration suppressed allergic responses in an ovalbumin-induced allergy mouse model. FEMS Immunol Med Microbiol 45:259–267. https://doi.org/10.1016/j.femsim.2005.05.005

    Article  CAS  PubMed  Google Scholar 

  10. Lee J, Bang J, Woo HJ (2013) Effect of orally administered Lactobacillus brevis HY7401 in a food allergy mouse model. J Microbiol Biotechnol 23:1636–1640. https://doi.org/10.4014/jmb.1306.06047

    Article  CAS  PubMed  Google Scholar 

  11. Martín R, Langella P (2019) Emerging health concepts in the probiotics field: streamlining the definitions. Front Microbiol 10:1047. https://doi.org/10.3389/fmicb.2019.01047

    Article  PubMed  PubMed Central  Google Scholar 

  12. Souza RO, Miranda VC, Quintanilha MF, Gallotti B, Oliveira SR, Silva JL, Alvarez-leite JI, Jesus LCL, Azevedo V, Vital KD, Fernandes SOA, Cardoso VN, Ferreira E, Nicoli JR, Martins FS (2023) Evaluation of the treatment with Akkermansia muciniphila BAA-835 of chemotherapy-induced mucositis in mice. Probiotics Antimicrob Proteins. https://doi.org/10.1007/s12602-023-10040-2

    Article  PubMed  Google Scholar 

  13. Kaźmierczak-Siedlecka K, Skonieczna-Żydecka K, Hupp T, Duchnowska R, Marek-Trzonkowska N, Połom K (2022) Next-generation probiotics - do they open new therapeutic strategies for cancer patients? Gut Microbes 14:2035659. https://doi.org/10.1080/19490976.2022.2035659

    Article  PubMed  PubMed Central  Google Scholar 

  14. Marcial-Coba MS, Cieplak T, Cahú TB, Blennow A, Knøchel S, Nielsen DS (2018) Viability of microencapsulated Akkermansia muciniphila and Lactobacillus plantarum during freeze-drying, storage and in vitro simulated upper gastrointestinal tract passage. Food Funct 9:5868–5879. https://doi.org/10.1039/C8FO01331D

    Article  CAS  PubMed  Google Scholar 

  15. Chelakkot C, Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH (2018) Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions. Exp Mol Med 50:e450–e450. https://doi.org/10.1038/emm.2017.282

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Derrien M, Belzer C, de Vos WM (2017) Akkermansia muciniphila and its role in regulating host functions. Microb Pathog 106:171–181. https://doi.org/10.1016/j.micpath.2016.02.005

    Article  PubMed  Google Scholar 

  17. Naito Y, Uchiyama K, Takagi T (2018) A next-generation beneficial microbe: Akkermansia muciniphila. J Clin Biochem Nutr 63:33–35. https://doi.org/10.3164/jcbn.18-57

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Cuevas-González PF, Liceaga AM, Aguilar-Toalá JE (2020) Postbiotics and paraprobiotics: from concepts to applications. Food Res Int 136:109502. https://doi.org/10.1016/j.foodres.2020.109502

    Article  CAS  PubMed  Google Scholar 

  19. Akter S, Park JH, Jung HK (2020) Potential health-promoting benefits of paraprobiotics, inactivated probiotic cells. J Microbiol Biotechnol 30:477–481. https://doi.org/10.4014/jmb.1911.11019

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, Van der Ark KCH, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD (2017) A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice. Nat Med 23:107–113. https://doi.org/10.1038/nm.4236

    Article  CAS  PubMed  Google Scholar 

  21. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch Ernst KI, Knutsen HK (2021) Safety of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 19:e06780. https://doi.org/10.2903/j.efsa.2021.6780

    Article  CAS  Google Scholar 

  22. Reeves P, Nielsen F, Fahey G (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123:1939–1951. https://doi.org/10.1093/jn/123.11.1939

    Article  CAS  PubMed  Google Scholar 

  23. Dourado LPA, Noviello MDLM, Alvarenga DM, Menezes Z, Perez DA, Batista NV, Menezes GB, Ferreira AVM, Souza DG, Cara DC (2011) Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice. Cell Immunol 270:198–206. https://doi.org/10.1016/j.cellimm.2011.05.008

    Article  CAS  PubMed  Google Scholar 

  24. Miranda VC, Santos SS, Assis HC, Faria AMC, Quintanilha MF, Morão RP, Nicoli JR, Cara DC, Martins FS (2020) Effect of Saccharomyces cerevisiae UFMG A-905 in a murine model of food allergy. Benefic Microbes 11:255–268. https://doi.org/10.3920/BM2019.0113

    Article  CAS  Google Scholar 

  25. Saldanha JCS, Gargiulo DL, Silva SS, Carmo-Pinto FH, Andrade MC, Alvarez-Leite JI, Teixeira MM, Cara DC (2004) A model of chronic IgE-mediated food allergy in ovalbumin-sensitized mice. Braz J Med Biol Res 37:809–816. https://doi.org/10.1590/S0100-879X2004000600005

    Article  CAS  PubMed  Google Scholar 

  26. Santos SS, Miranda VC, Trindade LM, Cardoso VN, Reis DC, Cassali GD, Nicoli JR, Cara DC, Martins FS (2021) Bifidobacterium longum subsp. longum 51A attenuates signs of inflammation in a murine model of food allergy. Probiotics Antimicrob Proteins. https://doi.org/10.1007/s12602-021-09846-9

    Article  PubMed  Google Scholar 

  27. Strath M, Warren DJ, Sanderson CJ (1985) Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors. J Immunol Methods 83:209–215. https://doi.org/10.1016/0022-1759(85)90242-X

    Article  CAS  PubMed  Google Scholar 

  28. Martins FS, Elian SD, Vieira AT, Tiago FC, Martins AK, Silva FC, Souza EL, Sousa LP, Araújo HR, Pimenta PF, Bonjardim CA, Arantes RM, Teixeira MM, Nicoli JR (2011) Oral treatment with Saccharomyces cerevisiae strain UFMG 905 modulates immune responses and interferes with signal pathways involved in the activation of inflammation in a murine model of typhoid fever. Int J Med Microbiol 301:359–364. https://doi.org/10.1016/j.ijmm.2010.11.002

    Article  PubMed  Google Scholar 

  29. Ling Z, Li Z, Liu X, Cheng Y, Luo Y, Tong X, Yuan L, Wang Y, Sun J, Li L, Xiang C (2014) Altered fecal microbiota composition associated with food allergy in infants. Appl Environ Microbiol 80:2546–2554. https://doi.org/10.1128/AEM.00003-14

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Cara DC, Conde AA, Vaz NM (1997) Immunological induction of flavour aversion in mice. II. Passive/adoptive transfer and pharmacological inhibition. Scand J Immunol 45:16–20. https://doi.org/10.1046/j.1365-3083.1997.d01-363.x

    Article  CAS  PubMed  Google Scholar 

  31. Cardoso CR, Provinciatto PR, Godoi DF, Fonseca MT, Ferreira BR, Teixeira G, Cunha FQ, Pinzan CF, Da Silva JS (2019) The signal transducer and activator of transcription 6 (STAT-6) mediates Th2 inflammation and tissue damage in a murine model of peanut-induced food allergy. Allergol Immunopathol 47:535–543. https://doi.org/10.1016/j.aller.2019.02.006

    Article  CAS  Google Scholar 

  32. Kapingidza AB, Kowal K, Chruszcz M (2020) Antigen–Antibody Complexes. In: Hoeger U, Harris J (eds) Vertebrate and invertebrate respiratory proteins, lipoproteins and other body fluid proteins. Subcellular Biochemistry, vol 94. Springer, Cham. https://doi.org/10.1007/978-3-030-41769-7_19

  33. Kelly BT, Grayson MH (2016) Immunoglobulin E, what is it good for? Ann Allergy Asthma Immunol 116:183–187. https://doi.org/10.1016/j.anai.2015.10.026

    Article  PubMed  PubMed Central  Google Scholar 

  34. Meulenbroek LA, de Jong RJ, den Hartog Jager CF, Monsuur HN, Wouters D, Nauta AJ, Knippels LMJ, Joost van Neerven RJ, Ruiter B, Leusen JHW, Hack CE, Bruijnzeel-Koomen CAFM, Knulst AC, Garssen J, van Hoffen E (2013) IgG antibodies in food allergy influence allergen–antibody complex formation and binding to B cells: a role for complement receptors. J Immunol 191:3526–3533. https://doi.org/10.4049/jimmunol.1202398

    Article  CAS  PubMed  Google Scholar 

  35. Miyajima I, Dombrowicz D, Martin TR, Ravetch JV, Kinet JP, Galli SJ (1997) Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE-or IgG1-dependent passive anaphylaxis. J Clin Investig 99:901–914. https://doi.org/10.1172/JCI119255

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Nunes MPO, van Tilburg MF, Tramontina Florean EOP, Guedes MIF (2019) Detection of serum and salivary IgE and IgG1 immunoglobulins specific for diagnosis of food allergy. PLoS ONE 14:e0214745. https://doi.org/10.1371/journal.pone.0214745

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Vidarsson G, Dekkers G, Rispens T (2014) IgG subclasses and allotypes: from structure to effector functions. Front Immunol 5:520. https://doi.org/10.3389/fimmu.2014.00520

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Fu L, Xie M, Wang C, Qian Y, Huang J, Sun Z, Zhang H, Wang Y (2020) Lactobacillus casei Zhang alleviates shrimp tropomyosin induced food allergy by switching antibody isotypes through the NF-κB-dependent immune tolerance. Mol Nutr Food Res 64:1900496. https://doi.org/10.1002/mnfr.201900496

    Article  CAS  Google Scholar 

  39. Fu L, Peng J, Zhao S, Zhang Y, Su X, Wang Y (2017) Lactic acid bacteria-specific induction of CD4+Foxp3+T cells ameliorates shrimp tropomyosin-induced allergic response in mice via suppression of mTOR signaling. Sci Rep 7:1987. https://doi.org/10.1038/s41598-017-02260-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Shin HS, Eom JE, Shin DU, Yeon SH, Lim SI, Lee SY (2018) Preventive effects of a probiotic mixture in an ovalbumin-induced food allergy model. J Microbiol Biotechnol 28:65–76. https://doi.org/10.4014/jmb.1708.08051

    Article  CAS  PubMed  Google Scholar 

  41. Acharya KR, Ackerman SJ (2014) Eosinophil granule proteins: form and function. J Biol Chem 289:17406–17415. https://doi.org/10.1074/jbc.R113.546218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Collins PD, Marleau S, Griffiths-Johnson DA, Jose PJ, Williams TJ (1995) Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. J Exp Med 182:1169–1174. https://doi.org/10.1084/jem.182.4.1169

    Article  CAS  PubMed  Google Scholar 

  43. Lacy P, Latif DA, Steward M, Musat-Marcu S, Man SP, Moqbel R (2003) Divergence of mechanisms regulating respiratory burst in blood and sputum eosinophils and neutrophils from atopic subjects. J Immunol 170:2670–2679. https://doi.org/10.4049/jimmunol.170.5.2670

    Article  CAS  PubMed  Google Scholar 

  44. Neves JS, Weller PF (2009) Functional extracellular eosinophil granules: novel implications in eosinophil immunobiology. Curr Opin Immunol 21:694–699. https://doi.org/10.1016/j.coi.2009.07.011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Ravin KA, Loy M (2016) The eosinophil in infection. Clin Rev Allergy Immunol 50:214–227. https://doi.org/10.1007/s12016-015-8525-4

    Article  CAS  PubMed  Google Scholar 

  46. Rosenberg HF (2016) Eosinophils. Encyclopedia of. Immunobiology 1:334–344. https://doi.org/10.1016/B978-0-12-374279-7.03007-1

    Article  Google Scholar 

  47. Rosenberg HF, Dyer KD, Foster PS (2013) Eosinophils: changing perspectives in health and disease. Nat Rev Immunol 13:9–22. https://doi.org/10.1038/nri3341

    Article  CAS  PubMed  Google Scholar 

  48. Spencer LA, Weller PF (2010) Eosinophils and Th2 immunity: contemporary insights. Immunol Cell Biol 88:250–256. https://doi.org/10.1038/icb.2009.115

    Article  PubMed  PubMed Central  Google Scholar 

  49. Aratani Y (2018) Myeloperoxidase: its role for host defense, inflammation, and neutrophil function. Arch Biochem Biophys 640:47–52. https://doi.org/10.1016/j.abb.2018.01.004

    Article  CAS  PubMed  Google Scholar 

  50. Petri B, Sanz MJ (2018) Neutrophil chemotaxis. Cell Tissue Res 371:425–436. https://doi.org/10.1007/s00441-017-2776-8

    Article  CAS  PubMed  Google Scholar 

  51. Sawant KV, Sepuru KM, Lowry E, Penaranda B, Frevert CW, Garofalo RP, Rajarathnam K (2021) Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: role of Cxcr2 activation and glycosaminoglycan interactions. J Leukoc Biol 109:777–791. https://doi.org/10.1002/JLB.3A0820-207R

    Article  CAS  PubMed  Google Scholar 

  52. Strzepa A, Pritchard KA, Dittel BN (2017) Myeloperoxidase: a new player in autoimmunity. Cell Immunol 317:1–8. https://doi.org/10.1016/j.cellimm.2017.05.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Muñoz-Cano R, Picado C, Valero A, Bartra J (2016) Mechanisms of anaphylaxis beyond IgE. J Investig Allergol Clin Immunol 26:73–82. https://doi.org/10.18176/jiaci.0046

  54. Yu W, Freeland DMH, Nadeau KC (2016) Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol 16:751–765. https://doi.org/10.1038/nri.2016.111

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Demirci M, Tokman HB, Uysal HK, Demiryas S, Karakullukcu A, Saribas S, Cokugras H, Kocazeybek BS (2019) Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma. Allergol Immunopathol 47:365–371. https://doi.org/10.1016/j.aller.2018.12.009

    Article  CAS  Google Scholar 

  56. Méndez CS, Bueno SM, Kalergis AM (2021) Contribution of gut microbiota to immune tolerance in infants. J Immunol Res 2021:7823316. https://doi.org/10.1155/2021/7823316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Nakayama J, Kobayashi T, Tanaka S, Korenori Y, Tateyama A, Sakamoto N, Kiyohara S, Shirakawa T, Sonomoto K (2011) Aberrant structures of fecal bacterial community in allergic infants profiled by 16S rRNA gene pyrosequencing. FEMS Immunol Med Microbiol 63:397–406. https://doi.org/10.1111/j.1574-695X.2011.00872.x

    Article  CAS  PubMed  Google Scholar 

  58. Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E (2017) Dysbiosis and the immune system. Nat Rev Immunol 17:219–232. https://doi.org/10.1038/nri.2017.7

    Article  CAS  PubMed  Google Scholar 

  59. Tsilochristou O, du Toit G, Sayre PH, Roberts G, Lawson K, Sever ML, Bahnson HT, Radulovic S, Basting M, Plaut M, Lack G (2019) Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol 144:494–503. https://doi.org/10.1016/j.jaci.2019.04.025

    Article  PubMed  Google Scholar 

  60. Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane SE, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL (2015) Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 45:632–643. https://doi.org/10.1111/cea.12487

    Article  CAS  PubMed  Google Scholar 

  61. Marcobal A, Barboza M, Froehlich JW, Block DE, German JB, Lebrilla CB, Mills DA (2010) Consumption of human milk oligosaccharides by gut related microbes. J Agric Food Chem 58:5334–5340. https://doi.org/10.1021/jf9044205

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Atarashi K, Honda K (2011) Microbiota in autoimmunity and tolerance. Curr Opin Immunol 23:761–768. https://doi.org/10.1016/j.coi.2011.11.002

    Article  CAS  PubMed  Google Scholar 

  63. Food and Agriculture Organization / World Health Organization (FAO/WHO) Working Group (2002) Guidelines for the evaluation of probiotics in food. FAO/WHO, London, ON, Canada

  64. Salminen S, Collado MC, Endo A, Hill C, Lebeer S, Quigley EM, Sanders ME, Shamir R, Swann JR, Szajewska H, Vinderola G (2021) The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Nat Rev Gastroenterol Hepatol 18:649–667. https://doi.org/10.1038/s41575-021-00440-6

    Article  PubMed  PubMed Central  Google Scholar 

  65. Liong MT (2008) Safety of probiotics: translocation and infection. Nutr Rev 66:192–202. https://doi.org/10.1111/j.1753-4887.2008.00024.x

    Article  PubMed  Google Scholar 

  66. Ottman N, Geerlings SY, Aalvink S, de Vos WM, Belzer C (2017) Action and function of Akkermansia muciniphila in microbiome ecology, health and disease. Best Pract Res Clin Gastroenterol 31:637–642. https://doi.org/10.1016/j.bpg.2017.10.001

    Article  PubMed  Google Scholar 

  67. Ottman N, Reunanen J, Meijerink M, Pietilä TE, Kainulainen V, Klievink J, Huuskonen L, Aalvink S, Skkurnik M, Boeren S, Satokari R, Mercenier A, Palva A, Smidt H, deVos W, Belzer C (2017) Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PLoS ONE 12:e0173004. https://doi.org/10.1371/journal.pone.0173004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

This work was supported by grants from the Brazilian National Council for Scientific and Technological Development (CNPq), the Coordination for the Improvement of Higher Education Personnel (CAPES), and the Research Support Foundation of the State of Minas Gerais (FAPEMIG), Brazil. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. VCM received a PhD fellowship from CNPq. AMCF, JRN, and FSM are CNPq fellowship holders.

Author information

Author notes

  1. Denise C. Cara and Flaviano S. Martins were co-supervisors and contributed equally to this work.

Authors and Affiliations

  1. Department of Microbiology, Federal University of Minas Gerais, Av. Antônio Carlos, Belo Horizonte, MG, 6627, 30270-901, Brazil

    Vivian C. Miranda, Ramon O. Souza, Mônica F. Quintanilha, Bruno Gallotti, Jacques R. Nicoli & Flaviano S. Martins

  2. Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Hélder C. Assis & Ana Maria C. Faria

  3. Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Denise C. Cara

Authors
  1. Vivian C. Miranda
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ramon O. Souza
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mônica F. Quintanilha
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bruno Gallotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hélder C. Assis
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ana Maria C. Faria
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Jacques R. Nicoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Denise C. Cara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Flaviano S. Martins
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

VCM and FSM analysed data and wrote the paper. FSM and DCC designed and supervised the research. VCM, ROS, MFQ, BG, and HCA, performed experiments and analysed data. AMCF, JRN, DCC, and FSM provided expertise in laboratory resources, improved the issue, and critically revised the article. All authors approved the final version of the article.

Corresponding author

Correspondence to Flaviano S. Martins.

Ethics declarations

Ethics Approval

All animal procedures were carried out according to the standards of the Brazilian Society of Laboratory Animal Science/Brazilian College for Animal Experimentation (available at http://www.mctic.gov.br/concea). This work was approved by the Ethics Committee in Animal Experimentation of the Federal University of Minas Gerais (CEUA/UFMG, protocol # 110/2019).

Conflict of Interest

The authors declare no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miranda, V.C., Souza, R.O., Quintanilha, M.F. et al. A Next-Generation Bacteria (Akkermansia muciniphila BAA-835) Presents Probiotic Potential Against Ovalbumin-Induced Food Allergy in Mice. Probiotics & Antimicro. Prot. (2023). https://doi.org/10.1007/s12602-023-10076-4

Download citation

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12602-023-10076-4

Keywords

Search

Navigation