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Antibacterial ability and biocompatibility of fluorinated titanium by plasma-based surface modification

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Abstract

Biomaterial surfaces with satisfied antibacterial activity and appropriate cytocompatibility are a pressing clinical need for orthopedic and dental implants. Fluorine-containing biomaterials have been demonstrated to obtain antibacterial activity and osteogenic property, while the effect of fluorine chemical compositions on antibacterial property and cytocompatibility is rarely studied. To this end, the coatings with different fluorine chemical compositions on titanium surface were prepared by plasma treatment to verify the antibacterial ability and cytocompatibility of fluorinated surfaces. Their antibacterial ability was evaluated by using Staphylococcus aureus, and the cell compatibility was investigated with MC3T3-E1 cells in vitro. The results show that both fluorocarbon coating and metal fluorides coating exhibited a hydrophilic and nano-scaled roughness. Rather than the fluorocarbon coating, the coating composed of metal fluorides presented satisfied bactericide effect and excellent cytocompatibility. The antibacterial mechanism is associated with the metal fluorides and released fluoride ion. This work would provide novel sight in optimizing the surface modification method of fluorinated biomaterials for biomedical applications.

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摘要

赋予生物材料表面良好的抗菌活性和生物相容性是临床骨科和牙科植入物的迫切需求。含氟生物材料已被证明具有抗菌活性和成骨性能, 而氟化学成分对材料的抗菌性能和生物相容性的影响却鲜有研究。为此, 本论文通过等离子体处理在纯钛表面制备了具有不同氟化学成分的涂层, 以验证氟化钛表面的抗菌能力和生物相容性。本论文采用金黄色葡萄球菌作为测试菌种评估材料的抗菌能力, 并在体外评价了材料与小鼠前成骨细胞MC3T3-E1的生物相容性。实验结果表明, 氟碳涂层和金属氟化物涂层均表现出亲水性和纳米级粗糙度。与氟碳涂层相比, 由金属氟化物组成的涂层表现出令人满意的杀菌效果和优异的细胞相容性。其抗菌机制与金属氟化物和释放的氟离子有关。这项工作将为制备新型含氟骨科生物材料提供实验依据和理论借鉴。

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Acknowledgements

This study was financially supported by the National Natural Science Foundation of China (No. 52001122, 51801064 and 51961012), Jiangxi Outstanding Young Talents Program (No. 20192BCB23014), and Jiangxi Key Research and Development Program (No. 20203BBE53050).

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Authors and Affiliations

  1. Jiangxi Key Laboratory of Nanobiomaterials, Institute of Advanced Materials, East China Jiaotong University, Nanchang, 330013, China

    Mian Chen, Xiao-Qiao Wang, Yi-Zao Wan & Jian Hu

  2. Key Laboratory for Anisotropy and Texture of Materials (ATM), School of Material Science and Engineering, Northeastern University, Shenyang, 110819, China

    Er-Lin Zhang

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  1. Mian Chen
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Chen, M., Wang, XQ., Zhang, EL. et al. Antibacterial ability and biocompatibility of fluorinated titanium by plasma-based surface modification. Rare Met. 41, 689–699 (2022). https://doi.org/10.1007/s12598-021-01808-y

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  • DOI: https://doi.org/10.1007/s12598-021-01808-y

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