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Promoting Osseointegration of New Innocuous Ti–18Zr–13Mo Implant Through Constructing Hierarchically Structured Bioactive Coating

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A Correction to this article was published on 19 August 2023

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Abstract

This study aimed to improve osteointegration performance of the new innocuous Ti–18Zr–13Mo implant through constructing hierarchically structured bioactive coating. A micro/nano-scaled fibrous network topography as well as bioactive components of calcium phosphate compounds were assigned to Ti–18Zr–13Mo alloy surface by a two stepped hydrothermal process for making its physical structure and chemical composition more closer to natural bone tissue. Scanning electron microscopy, transmission electron microscope, energy dispersive spectrometer, X-ray diffraction, X-ray photoelectron spectroscopy, atomic force microscopy and contact angle measurement had been applied to characterize the surface coating. Furthermore, we in-depth explored the formation process and mechanism of the hybrid bionic coating using knowledge of energetic and crystallography. Following the treatment, the coated Ti–18Zr–13Mo implant showed significant boosting of MC3T3-E1 osteoblasts’ activity, adhesion and differentiation ability in vitro. The modification technology of the hierarchical bioactive coating can provide a strong guarantee for practical orthopedic and dental applications of Ti–18Zr–13Mo implant. Besides, the promising results will further expand the research fertile ground of Ti-based alloy and other metal implant and prosthesis.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (52001324), Key Research and Development Program of Henan Province (222102310441), National Science Foundation of Jiangsu Province (BK20200643) and Henan Excellent Youth Science Foundation project (212300410039).

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Authors and Affiliations

  1. College of Medical Technology and Engineering, Henan University of Science and Technology, 263 Kaiyuan Avenue, Luoyang, 471023, China

    Bianyun Cai, Guangda Li, Kun Lei & Meng Han

  2. School of Materials Science and Engineering, Southeast University, Nanjing, 211189, China

    Zhijun Guo

  3. School of Materials Science and Physics, China University of Mining and Technology, Xuzhou, 221116, China

    Delin Yuan & Zhijun Guo

  4. Department of Orthopedic Surgery and Orthopedic Research Institute, Laboratory of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China

    Yizhou Huang

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  1. Bianyun Cai
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The original online version of this article was revised due to the figures 2b,3b,3d,7b were published incorrectly and the figures have been corrected.

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Cai, B., Yuan, D., Li, G. et al. Promoting Osseointegration of New Innocuous Ti–18Zr–13Mo Implant Through Constructing Hierarchically Structured Bioactive Coating. Met. Mater. Int. 29, 3402–3417 (2023). https://doi.org/10.1007/s12540-023-01455-1

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