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Different approaches for patent ductus arteriosus in premature infants using acetaminophen

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Abstract

Background

Acetaminophen use for pharmacological treatment of hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants is becoming more popular with emerging evidence that it is effective as well as safe alternative for other agents used to close hsPDA.

Data sources

We performed a narrative review of literature about pharmacological treatment of PDA using acetaminophen.

Results

Acetaminophen was used as a prophylaxis, symptomatic, targeted, and a rescue approach.

Conclusions

It appears that acetaminophen could be used in different approaches to close the hsPDA. Long-term outcomes of acetaminophen exposure early in life still lack certainty.

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Data availability

All data and articles supporting the findings of this study are available within the article in the reference section.

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Authors and Affiliations

  1. Northern Alberta Neonatal Program Royal Alexandra Hospital Site NICU, DTC 5027, Stollery Children Hospital, University of Alberta, 10240 Kingsway NW, Edmonton, AB, T5H 3V9, Canada

    Aimann Surak & Abbas Hyderi

  2. Department of Pediatrics, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Amish Jain

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  1. Aimann Surak
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  2. Amish Jain
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  3. Abbas Hyderi
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SA and JA reviewed literature and drafted the manuscript. HA reviewed literature and supervised the manuscript. All authors approved the final version of the manuscript.

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Correspondence to Aimann Surak.

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No financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. No conflict of interest to declare for all authors.

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Surak, A., Jain, A. & Hyderi, A. Different approaches for patent ductus arteriosus in premature infants using acetaminophen. World J Pediatr 18, 243–250 (2022). https://doi.org/10.1007/s12519-022-00526-4

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  • DOI: https://doi.org/10.1007/s12519-022-00526-4

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