Skip to main content
SpringerLink
Log in

Orofaryngeale slikstoornissen bij neurodegeneratieve aandoeningen

  • Published:
Tijdschrift voor Gerontologie en Geriatrie

Oropharyngeal dysphagia in neurodegenerative diseases

Neurodegenerative diseases are progressive degenerations of the brain with increasing movement disorders, like gait, speech and swallowing disorders combined with cognitive disorders, like dementia. Neurodegenerative diseases have in common that aspiration pneumonia is the most frequent cause of death in the end-stage of the disease. This article provides an overview of the prevalence, characteristics and treatments of oropharyngeal dysphagia resulting from multiple system atrophy (MSA), progressive supranuclear palsy (PSP), Huntington’s disease (HD), multiple sclerosis (MS) and dementia. The prevalence of dysphagia ranges from 32% in MS, 57% in patients with dementia to 73% in patients with MSA and almost 100% in patients with PSP or HD. Treatment is aimed at swallowing with less effort, swallowing more safely and/or optimal nutritional intake. When cognitive decline and behavioural changes increase, passive compensations like food adaptations and comfortable mealtime conditions become the principal interventions.

Samenvatting

Neurodegeneratieve aandoeningen zijn progressieve ziekten van het zenuwstelsel, met toenemende bewegingsstoornissen, zoals stoornissen in het lopen, spreken en slikken in combinatie met cognitieve stoornissen, waaronder dementie. Neurodegeneratieve aandoeningen hebben met elkaar gemeen dat aspiratiepneumonie in het eindstadium van de ziekte de belangrijkste doodsoorzaak is. Dit artikel geeft een overzicht van de prevalentie, kenmerken en behandeling van orofaryngeale slikstoornissen bij multisysteem atrofie (MSA) en progressieve supranucleaire paralyse (PSP), de ziekte van Huntington, multiple sclerose en dementiesyndromen. De prevalentie van slikstoornissen varieert van ongeveer 32% bij multiple sclerose en 57% bij dementiesyndromen tot 73% bij MSA en bijna 100% bij PSP en de ziekte van Huntington. De behandeling is gericht op slikken met minder inspanning, veiliger slikken en/of een betere voedingsintake. Naarmate cognitieve stoornissen en gedragsveranderingen toenemen, gaan passieve interventies, zoals aanpassen van voedingsconsistenties en een prettige eetomgeving, een grotere rol spelen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literatuur

  1. Bloem BR, van Laar T, Keus SHJ, de Beer H, Poot E, Buskens E, et al. Multidisciplinaire richtlijn ziekte van Parkinson. Alphen a/d Rijn: Van Zuiden Communications, 2010.

    Google Scholar 

  2. Kalf JG. Orofaryngeale slikstoornissen bij de ziekte van Parkinson. Tijdschrift voor Gerontologie en Geriatrie 2014;45.

  3. Granata G, Wenning GK. Multiple system atrophy. In: Colosimo C, Riley DE, Wenning GK, editors. Handbook of Atypical Parkinsonism. New York: Cambridge University Press, 2011.

    Google Scholar 

  4. Colosimo C, Fabbrini G, Berardelli A. Progressive supranuclear palsy. In: Colosimo C, Riley DE, Wenning GK, editors. Handbook of Atypical Parkinsonism. New York: Cambridge University Press, 2011.

    Chapter  Google Scholar 

  5. Neurologie NVv. Rcihtlijn Multiple Sclerose. Houten: Bohn Stafleu Van Loghum, 2012.

  6. O’Sullivan SS, Massey LA, Williams DR, Silveira-Moriyama L, Kempster PA, Holton JL, et al. Clinical outcomes of progressive supranuclear palsy and multiple system atrophy. Brain 2008;131(Pt 5):1362–72.

    PubMed  Google Scholar 

  7. Muller J, Wenning GK, Verny M, McKee A, Chaudhuri KR, Jellinger K, et al. Progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders. Arch Neurol 2001;58(2):259–64.

    Article  PubMed  CAS  Google Scholar 

  8. Litvan I, Sastry N, Sonies BC. Characterizing swallowing abnormalities in progressive supranuclear palsy. Neurology 1997;48(6):1654–62.

    Article  PubMed  CAS  Google Scholar 

  9. Heemskerk AW, Roos RA. Aspiration pneumonia and death in Huntington’s disease. PLoS currents 2012;4:RRN1293.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Calcagno P, Ruoppolo G, Grasso MG, De Vincentiis M, Paolucci S. Dysphagia in multiple sclerosis—prevalence and prognostic factors. Acta neurologica Scandinavica 2002;105(1):40–3.

    Article  PubMed  CAS  Google Scholar 

  11. Alagiakrishnan K, Bhanji RA, Kurian M. Evaluation and management of oropharyngeal dysphagia in different types of dementia: a systematic review. Archives of gerontology and geriatrics 2013;56(1):1–9.

    Article  PubMed  Google Scholar 

  12. Kalf JG, Borm GF, de Swart BJ, Bloem BR, Zwarts MJ, Munneke M. Reproducibility and validity of patient-rated assessment of speech, swallowing, and saliva control in Parkinson’s disease. Arch Phys Med Rehabil 2011;92(7):1152–8.

    Article  PubMed  Google Scholar 

  13. Bergamaschi R, Crivelli P, Rezzani C, Patti F, Solaro C, Rossi P, et al. The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosis. Journal of the neurological sciences 2008;269(1–2):49–53.

    Article  PubMed  CAS  Google Scholar 

  14. Langmore SE, Terpenning MS, Schork A, Chen Y, Murray JT, Lopatin D, et al. Predictors of aspiration pneumonia: how important is dysphagia? Dysphagia 1998;13(2):69–81.

    Article  PubMed  CAS  Google Scholar 

  15. van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C. Risk factors for aspiration pneumonia in frail older people: a systematic literature review. Journal of the American Medical Directors Association 2011;12(5):344–54.

    Article  PubMed  Google Scholar 

  16. Beyer MK, Herlofson K, Arsland D, Larsen JP. Causes of death in a community-based study of Parkinson’s disease. Acta Neurol Scand 2001;103(1):7–11.

    Article  PubMed  CAS  Google Scholar 

  17. Mehanna R, Jankovic J. Respiratory problems in neurologic movement disorders. Parkinsonism Relat Disord 2010;16(10):628–38.

    Article  PubMed  Google Scholar 

  18. Prosiegel M, Schelling A, Wagner-Sonntag E. Dysphagia and multiple sclerosis. International MS journal / MS Forum 2004;11(1):22–31.

    PubMed  CAS  Google Scholar 

  19. Romero JP, Benito-Leon J, Louis ED, Pareja FB. Under Reporting of Dementia Deaths on Death Certificates: A Systematic Review of Population-based Cohort Studies. Journal of Alzheimer’s disease : JAD 2014.

  20. Kalf H, van Keeken P, Dicke H, Rood B. Slikstoornissen bij volwassenen. Een interdisciplinaire benadering. Houten: Bohn Stafleu Van Loghum, 2008.

    Google Scholar 

  21. Garcia JM, Chambers Et. Managing dysphagia through diet modifications. The American journal of nursing 2010;110(11):26–33; quiz 34–5.

    Article  PubMed  Google Scholar 

  22. Huckabee ML, Pelletier CA. Management of Adult Neurogenic Dysphagia. New York: Thomson Delmar Learning, 2003.

    Google Scholar 

  23. Cichero JA, Steele C, Duivestein J, Clave P, Chen J, Kayashita J, et al. The Need for International Terminology and Definitions for Texture-Modified Foods and Thickened Liquids Used in Dysphagia Management: Foundations of a Global Initiative. Current physical medicine and rehabilitation reports 2013;1:280–91.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Rosenbek JC, Jones HN. Dysphagia in Movement Disorders. San Diego: Plural Publishing, 2009.

    Google Scholar 

  25. Troche MS, Okun MS, Rosenbek JC, Musson N, Fernandez HH, Rodriguez R, et al. Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial. Neurology 2010;75(21):1912–19.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  26. Bulow M, Olsson R, Ekberg O. Videomanometric analysis of supraglottic swallow, effortful swallow, and chin tuck in patients with pharyngeal dysfunction. Dysphagia 2001;16(3):190–95.

    Article  PubMed  CAS  Google Scholar 

  27. Shanahan TK, Logemann JA, Rademaker AW, Pauloski BR, Kahrilas PJ. Chin-down posture effect on aspiration in dysphagic patients. Arch Phys Med Rehabil 1993;74(7):736–39.

    Article  PubMed  CAS  Google Scholar 

  28. Whear R, Abbott R, Thompson-Coon J, Bethel A, Rogers M, Hemsley A, et al. Effectiveness of mealtime interventions on behavior symptoms of people with dementia living in care homes: a systematic review. Journal of the American Medical Directors Association 2014;15(3):185–93.

    Article  PubMed  Google Scholar 

  29. Colosimo C, Riley DE, Wenning GK. Handbook of Atypical Parkinsonism. Cambridge: Cambridge University Press, 2011.

    Book  Google Scholar 

  30. Wenning GK, Geser F, Krismer F, Seppi K, Duerr S, Boesch S, et al. The natural history of multiple system atrophy: a prospective European cohort study. Lancet neurology 2013;12(3):264–74.

    Article  PubMed Central  Google Scholar 

  31. Alfonsi E, Versino M, Merlo IM, Pacchetti C, Martignoni E, Bertino G, et al. Electrophysiologic patterns of oral-pharyngeal swallowing in parkinsonian syndromes. Neurology 2007;68(8):583–89.

    Article  PubMed  CAS  Google Scholar 

  32. Kalf JG, de Swart BJM, Bonnier MWJ, Hofman MFC, Kanters JHM, Kocken JEM, et al. Logopedie bij de ziekte van Parkinson. Een richtlijn van de Nederlandse Vereniging voor Logopedie en Foniatrie. Woerden: NVLF/Uitgeverij LEMMA, 2008.

    Google Scholar 

  33. Higo R, Nito T, Tayama N. Swallowing function in patients with multiple-system atrophy with a clinical predominance of cerebellar symptoms (MSA-C). European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies 2005;262(8):646–50.

    Article  Google Scholar 

  34. Coelho M, Marti MJ, Tolosa E, Ferreira JJ, Valldeoriola F, Rosa M, et al. Late-stage Parkinson’s disease: the Barcelona and Lisbon cohort. J Neurol 2010;257(9):1524–32.

    Article  PubMed  Google Scholar 

  35. Merlo IM, Occhini A, Pacchetti C, Alfonsi E. Not paralysis, but dystonia causes stridor in multiple system atrophy. Neurology 2002;58(4):649–52.

    Article  PubMed  Google Scholar 

  36. Higo R, Tayama N, Watanabe T, Nitou T, Takeuchi S. Vocal fold motion impairment in patients with multiple system atrophy: evaluation of its relationship with swallowing function. J Neurol Neurosurg Psychiatry 2003;74(7):982–84.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  37. dell’Aquila C, Zoccolella S, Cardinali V, de Mari M, Iliceto G, Tartaglione B, et al. Predictors of survival in a series of clinically diagnosed progressive supranuclear palsy patients. Parkinsonism & related disorders 2013;19(11):980–5.

    Article  Google Scholar 

  38. Brown RG, Lacomblez L, Landwehrmeyer BG, Bak T, Uttner I, Dubois B, et al. Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy. Brain 2010;133(Pt 8):2382–93.

    Article  PubMed  Google Scholar 

  39. Klempir J, Klempirova O, Spackova N, Zidovska J, Roth J. Unified Huntington’s Disease Rating Scale: clinical practice and a critical approach. Functional Neurology 2006;21(4):217–21.

    PubMed  Google Scholar 

  40. Group HS. Unified Huntington’s Disease Rating Scale: Reliability and Consistency. Movement Disorders 1996;11(2):136–42.

    Article  Google Scholar 

  41. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 2008;23(15):2129–70.

    Article  PubMed  Google Scholar 

  42. Wenning GK, Tison F, Seppi K, Sampaio C, Diem A, Yekhlef F, et al. Development and validation of the Unified Multiple System Atrophy Rating Scale (UMSARS). Movement disorders : official journal of the Movement Disorder Society 2004;19(12):1391–402.

    Article  Google Scholar 

  43. Heemskerk AW, Roos RA. Dysphagia in Huntington’s disease: a review. Dysphagia 2011;26(1):62–6.

    Article  PubMed  Google Scholar 

  44. Chaudhuri A. Multiple sclerosis is primarily a neurodegenerative disease. Journal of neural transmission (Vienna, Austria : 1996) 2013;120(10):1463–6.

  45. Poorjavad M, Derakhshandeh F, Etemadifar M, Soleymani B, Minagar A, Maghzi AH. Oropharyngeal dysphagia in multiple sclerosis. Mult Scler 2010;16(3):362–65.

    Article  PubMed  Google Scholar 

  46. Solaro C, Rezzani C, Trabucco E, Amato MP, Zipoli V, Portaccio E, et al. Prevalence of patient-reported dysphagia in multiple sclerosis patients: an Italian multicenter study (using the DYMUS questionnaire). Journal of the neurological sciences 2013;331(1–2):94–7.

    Article  PubMed  CAS  Google Scholar 

  47. De Pauw A, Dejaeger E, D’hooghe B, Carton H. Dysphagia in multiple sclerosis. Clin Neurol Neurosurg. 2002;104(4):345–51.

    Article  PubMed  Google Scholar 

  48. Bogaardt H, van Dam D, Wever NM, Bruggeman CE, Koops J, Fokkens WJ. Use of neuromuscular electrostimulation in the treatment of dysphagia in patients with multiple sclerosis. Ann Otol Rhinol Laryngol 2009;118(4):241–6.

    Article  PubMed  Google Scholar 

  49. Altman KW, Richards A, Goldberg L, Frucht S, McCabe DJ. Dysphagia in stroke, neurodegenerative disease, and advanced dementia. Otolaryngologic clinics of North America 2013;46(6):1137–49.

    Article  PubMed  Google Scholar 

  50. de Medeiros Correia S, Morillo LS, Filho WJ, Mansur LL. Swallowing in moderate and severe phases of Alzheimer’s disease. Arq Arq Neuropsiquiatr 2010;68(6):855–61.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radboudumc Nijmegen, Afdeling Revalidatie, Sectie Logopedie, Nijmegen, The Netherlands

    J. G. Kalf

  2. Advies- en Behandelcentrum Liemerije Zevenaar, Nijmegen, The Netherlands

    S. de Wit

Authors
  1. J. G. Kalf
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. de Wit
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. G. Kalf.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kalf, J.G., de Wit, S. Orofaryngeale slikstoornissen bij neurodegeneratieve aandoeningen. Tijdschr Gerontol Geriatr 45, 273–281 (2014). https://doi.org/10.1007/s12439-014-0091-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12439-014-0091-3

Keywords

Trefwoorden

Search

Navigation