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Oxytocin plasma concentrations in children and adolescents with autism spectrum disorder: correlation with autistic symptomatology

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ADHD Attention Deficit and Hyperactivity Disorders

Abstract

Findings from research in animal models and humans have shown a clear role for the neuropeptide oxytocin (OT) on complex social behaviors. This is also true in the context of autism spectrum disorder (ASD). Previous studies on peripheral OT concentrations in children and young adults have reported conflicting results with the initial studies presenting mainly decreased OT plasma levels in ASD compared to healthy controls. Our study therefore aimed to further investigate changes in peripheral OT concentrations as a potential surrogate for the effects observed in the central nervous system (CNS) in ASD. OT plasma concentrations were assessed in 19 male children and adolescents with ASD, all with an IQ > 70 (age 10.7 ± 3.8 years), 17 healthy male children (age 13.6 ± 2.1 years) and 19 young male patients with attention deficit hyperactivity disorder (ADHD) as a clinical control group (age 10.4 ± 1.9 years) using a validated radioimmunoassay. Analysis of covariance revealed significant group differences in OT plasma concentrations (F(2, 48) = 9.574, p < 0.001, η 2 = 0.285; plasma concentrations ASD 19.61 ± 7.12 pg/ml, ADHD 8.05 ± 5.49 pg/ml, healthy controls 14.43 ± 9.64 pg/ml). Post hoc analyses showed significantly higher concentrations in children with ASD compared to ADHD (p < 0.001). After Bonferroni correction, there was no significant difference in ASD in comparison with healthy controls (p = 0.132). A significant strong correlation between plasma OT and autistic symptomatology, assessed by the Autism Diagnostic Observation Schedule, was observed in the ASD group (p = 0.013, r = 0.603). Patients with ADHD differed from healthy control children by significantly decreased OT concentrations (p = 0.014). No significant influences of the covariates age, IQ, medication and comorbidity could be seen. Our preliminary results point to a correlation of OT plasma concentrations with autistic symptom load in children with ASD and a modulation of the OT system also in the etiologically and phenotypically overlapping disorder ADHD. Further studies in humans and animal models are warranted to clarify the complex association of the OT system with social impairments as well as stress-related and depressive behavior and whether peripheral findings reflect primary changes of OT synthesis and/or release in relevant areas of the CNS.

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References

  • Achenbach TM, Edelbrock CS (1981) Behavioral problems and competencies reported by parents of normal and disturbed children aged four through sixteen. Monogr Soc Res Child Dev 46(1):1–82

    Article  CAS  PubMed  Google Scholar 

  • Al-Ayadhi LY (2005) Altered oxytocin and vasopressin levels in autistic children in Central Saudi Arabia. Neurosciences (Riyadh) 10(1):47–50

    Google Scholar 

  • American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders. DSM-5, 5th edn. American Psychiatric Association, Washington, DC

  • Anagnostou E, Soorya L, Chaplin W, Bartz J, Halpern D, Wasserman S, Wang AT, Pepa L, Tanel N, Kushki A, Hollander E (2012) Intranasal oxytocin versus placebo in the treatment of adults with autism spectrum disorder: a randomized controlled trial. Mol Autism 3(1):16

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Andari E, Duhamel J, Zalla T, Herbrecht E, Leboyer M, Sirigu A (2010) Promoting social behavior with oxytocin in high-functioning autism spectrum disorder. Proc Natl Acad Sci USA 107(9):4389–4394

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Bartz JA, Zaki J, Bolger N, Ochsner KN (2011) Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci (Regul. Ed.) 15(7):301–309

    CAS  Google Scholar 

  • Boelte S, Rühl D, Schmoetzer G, Poustka F (2006) Diagnostisches Interview fuer Autismus—Revidiert. Verlag Hans Huber, Bern

    Google Scholar 

  • Campbell DB, Datta D, Jones ST, Lee EB, Sutcliffe JS, Hammock EAD, Levitt P (2011) Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder. J Neurodev Disord 3(2):101–112

    Article  PubMed Central  PubMed  Google Scholar 

  • Cattell RB (1949) Culture free intelligence test, scale 1, handbook. Institute of Personality and Ability Testing Inc., Champaign

    Google Scholar 

  • Cattell RB, Weiß RH, Osterland J (1997) Grundintelligenztest Skala 1, CFT 1, 5. revidierte Auflage. Hogrefe, Göttingen

    Google Scholar 

  • Corbett BA, Schupp CW, Levine S, Mendoza S (2009) Comparing cortisol, stress, and sensory sensitivity in children with autism. Autism Res 2(1):39–49

    Article  PubMed Central  PubMed  Google Scholar 

  • Cyranowski JM, Hofkens TL, Frank E, Seltman H, Cai H, Amico JA (2008) Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med 70(9):967–975

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dadds MR, Macdonald E, Cauchi A, Williams K, Levy F, Brennan J (2013) Nasal oxytocin for social deficits in childhood autism: a randomized controlled trial. J Autism Dev Disord 44:521–531

  • de Wied D, Diamant M, Fodor M (1993) Central nervous system effects of the neurohypophyseal hormones and related peptides. Front Neuroendocrinol 14(4):251–302

    Article  PubMed  Google Scholar 

  • Devarajan K, Rusak B (2004) Oxytocin levels in the plasma and cerebrospinal fluid of male rats: effects of circadian phase, light and stress. Neurosci Lett 367(2):144–147

    Article  CAS  PubMed  Google Scholar 

  • Domes G, Heinrichs M, Glascher J, Buchel C, Braus DF, Herpertz SC (2007) Oxytocin attenuates amygdale responses to emotional faces regardless of valence. Biol Psychiatry 62(10):1187–1190

    Article  CAS  PubMed  Google Scholar 

  • Döpfner M, Melchers P, Fegert J, Lehmkuhl G, Lehmkuhl U, Schmeck K, Steinhausen H, Poustka F (1994) Deutschsprachige Konsensus-Versionen der Child Behavior Checklist (CBCL/4-18), der Teacher Report Form (TRF), und der Youth Self-Report Form (YSR). Kindheit und Entwicklung 3(7):54–59

    Google Scholar 

  • Gimpl G, Fahrenholz F (2001) The oxytocin receptor system: structure, function, and regulation. Physiol Rev 81(2):629–683

    CAS  PubMed  Google Scholar 

  • Glovinsky D, Kalogeras KT, Kirch DG, Suddath R, Wyatt RJ (1994) Cerebrospinal fluid oxytocin concentration in schizophrenic patients does not differ from control subjects and is not changed by neuroleptic medication. Schizophr Res 11(3):273–276

    Article  CAS  PubMed  Google Scholar 

  • Green JJ, Hollander E (2010) Autism and oxytocin: new developments in translational approaches to therapeutics. Neurotherapeutics 7(3):250–257

    Article  CAS  PubMed  Google Scholar 

  • Green L, Fein D, Modahl C, Feinstein C, Waterhouse L, Morris M (2001) Oxytocin and autistic disorder: alterations in peptide forms. Biol Psychiatry 50(8):609–613

    Article  CAS  PubMed  Google Scholar 

  • Gregory SG, Connelly JJ, Towers AJ, Johnson J, Biscocho D, Markunas CA, Lintas C, Abramson RK, Wright HH, Ellis P, Langford CF, Worley G, Delong GR, Murphy SK, Cuccaro ML, Persico A, Pericak-Vance MA (2009) Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Med 7:62

    Article  PubMed Central  PubMed  Google Scholar 

  • Grippo AJ, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Carter CS (2007) Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology 32(8–10):966–980

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Guastella AJ, Einfeld SL, Gray KM, Rinehart NJ, Tonge BJ, Lambert TJ, Hickie IB (2010) Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorder. Biol Psychiatry 67(7):692–694

    Article  CAS  PubMed  Google Scholar 

  • Hattori J, Ogino T, Abiru K, Nakano K, Oka M, Ohtsuka Y (2006) Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders? Brain Dev 28:371–374

  • Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54(12):1389–1398

    Article  CAS  PubMed  Google Scholar 

  • Hollander E, Novotny S, Hanratty M, Yaffe R, DeCaria CM, Aronowitz BR, Mosovich S (2003) Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger’s disorders. Neuropsychopharmacology 28(1):193–198

    Article  CAS  PubMed  Google Scholar 

  • Hollander E, Bartz J, Chaplin W, Phillips A, Sumner J, Soorya L, Anagnostou E, Wasserman S (2007) Oxytocin increases retention of social cognition in autism. Biol Psychiatry 61(4):498–503

    Article  CAS  PubMed  Google Scholar 

  • Holt-Lunstad J, Birmingham W, Light KC (2011) The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention. Psychoneuroendocrinology 36(8):1249–1256

    Article  CAS  PubMed  Google Scholar 

  • Insel TR (1997) A neurobiological basis of social attachment. Am J Psychiatry 154(6):726–735

    CAS  PubMed  Google Scholar 

  • Insel TR (2010) The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 65(6):768–769

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Insel TR, O’Brien DJ, Leckman JF (1999) Oxytocin, vasopressin, and autism: is there a connection? Biol Psychiatry 45(2):145–157

    Article  CAS  PubMed  Google Scholar 

  • Jacob S, Brune CW, Carter CS, Leventhal BL, Lord C, Cook EH (2007) Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 417(1):6–9

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Jansen LMC, Gispen-de Wied CC, Wiegant VM, Westenberg HGM, Lahuis BE, van Engeland H (2006) Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. J Autism Dev Disord 36(7):891–899

    Article  PubMed  Google Scholar 

  • Kagerbauer SM, Martin J, Schuster T, Blobner M, Kochs EF, Landgraf R (2013) Plasma oxytocin and vasopressin do not predict neuropeptide concentrations in human cerebrospinal fluid. J Neuroendocrinol 25(7):668–673

    Article  CAS  PubMed  Google Scholar 

  • Kaufman AS, Kaufman NL (2004) Kaufman assessment battery for children, 2nd edn. Pearson Inc., Bloomington

    Google Scholar 

  • Keating C, Dawood T, Barton DA, Lambert GW, Tilbrook AJ (2013) Effects of selective serotonin reuptake inhibitor treatment on plasma oxytocin and cortisol in major depressive disorder. BMC Psychiatry 13:124

    Article  PubMed Central  PubMed  Google Scholar 

  • Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A (2005) Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 25(49):11489–11493

    Article  CAS  PubMed  Google Scholar 

  • Kumsta R, Hummel E, Chen FS, Heinrichs M (2013) Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience. Front Neurosci 7:83

    Article  PubMed Central  PubMed  Google Scholar 

  • Lai M, Lombardo MV, Baron-Cohen S (2013) Autism. Lancet 383(9920):896–910

    Article  PubMed  Google Scholar 

  • Landgraf R, Häcker R, Buhl H (1982) Plasma vasopressin and oxytocin in response to exercise and during a day-night cycle in man. Endocrinology 79(2):281–291

    CAS  Google Scholar 

  • Lord C, Rutter M, Goode S, Heemsbergen J, Jordan H, Mawhood L, Schopler E (1989) Autism diagnostic observation schedule: a standardized observation of communicative and social behavior. J Autism Dev Disord 19(2):185–212

    Article  CAS  PubMed  Google Scholar 

  • Lord C, Rutter M, Le Couteur A (1994) Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24(5):659–685

    Article  CAS  PubMed  Google Scholar 

  • Lukas M, Neumann ID (2013) Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorder. Behav Brain Res 251:85–94

    Article  CAS  PubMed  Google Scholar 

  • McCarthy MM (1995) Estrogen modulation of oxytocin and its relation to behavior. Adv Exp Med Biol 395:235–245

    CAS  PubMed  Google Scholar 

  • McCullough ME, Churchland PS, Mendez AJ (2013) Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted? Neurosci Biobehav Rev 37(8):1485–1492

    Article  CAS  PubMed  Google Scholar 

  • Melchers P, Preuß U (2009) Kaufmann assessment battery for children, 8. unveränderte Auflage. Pearson Assessment, Frankfurt/Main

    Google Scholar 

  • Miller GA, Chapman JP (2001) Misunderstanding analysis of covariance. J Abnorm Psychol 110(1):40–48

    Article  CAS  PubMed  Google Scholar 

  • Miller M, Bales KL, Taylor SL, Yoon J, Hostetler CM, Carter CS, Solomon M (2013) Oxytocin and vasopressin in children and adolescents with autism spectrum disorder: sex differences and associations with symptoms. Autism Res 6(2):91–102

    Article  PubMed Central  PubMed  Google Scholar 

  • Modahl C, Green L, Fein D, Morris M, Waterhouse L, Feinstein C, Levin H (1998) Plasma oxytocin levels in autistic children. Biol Psychiatry 43(4):270–277

    Article  CAS  PubMed  Google Scholar 

  • Morris M, Castro M, Rose JC (1992) Alterations in oxytocin prohormone processing during early development in the fetal sheep. Am J Physiol 263(3 Pt 2):R738–R740

    CAS  PubMed  Google Scholar 

  • Neumann ID, Landgraf R (2012) Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. Trends Neurosci 35(11):649–659

    Article  CAS  PubMed  Google Scholar 

  • Neumann ID, Maloumby R, Beiderbeck DI, Lukas M, Landgraf R (2013) Increased brain and plasma oxytocin after nasal and peripheral administration in rats and mice. Psychoneuroendocrinology 38(10):1985–1993

    Article  CAS  PubMed  Google Scholar 

  • Nishioka T, Anselmo-Franci JA, Li P, Callahan MF, Morris M (1998) Stress increases oxytocin release within the hypothalamic paraventricular nucleus. Brain Res 781(1–2):57–61

    Article  CAS  PubMed  Google Scholar 

  • Noterdaeme MA, Wriedt E (2010) Begleitsymptomatik bei tief greifenden Entwicklungsstörungen (Comorbidity in autism spectrum disorder-I. Mental retardation and psychiatric comorbidity). Z Kinder Jugendpsychiatr Psychother 38(4):257–266

    Article  PubMed  Google Scholar 

  • Ozsoy S, Esel E, Kula M (2009) Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res 169(3):249–252

    Article  CAS  PubMed  Google Scholar 

  • Park J, Willmott M, Vetuz G, Toye C, Kirley A, Hawi Z, Brookes KJ, Gill M, Kent L (2010) Evidence that genetic variation in the oxytocin receptor (OXTR) gene influences social cognition in ADHD. Prog Neuropsychopharmacol Biol Psychiatry 34(4):697–702

    Article  CAS  PubMed  Google Scholar 

  • Petermann F, Petermann U (2007) Hamburg Wechsel Intelligenz Test für Kinder, IV: HAWIK-IV (3. ergänzte Aufl.), 3. ergänzte Aufl. Verlag Hans Huber, Bern

    Google Scholar 

  • Reiersen AM, Constantino JN, Volk HE, Todd RD (2007) Autistic traits in a population-based ADHD twin sample. J Child Psychol Psychiatry 48(5):464–472

    Article  PubMed  Google Scholar 

  • Rommelse NNJ, Franke B, Geurts HM, Hartman CA, Buitelaar JK (2010) Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur Child Adolesc Psychiatry 19(3):281–295

    Article  PubMed Central  PubMed  Google Scholar 

  • Ruehl D, Boelte S, Feineis-Matthews S, Poustka F (2004) ADOS—Diagnostische Beobachtungsskala fuer Autistische Stoerungen. Verlag Hans Huber, Bern

    Google Scholar 

  • Sala M, Braida D, Lentini D, Busnelli M, Bulgheroni E, Capurro V, Finardi A, Donzelli A, Pattini L, Rubino T, Parolaro D, Nishimori K, Parenti M, Chini B (2011) Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biol Psychiatry 69(9):875–882

    Article  CAS  PubMed  Google Scholar 

  • Santosh PJ, Mijovic A (2004) Social impairment in hyperkinetic disorder—relationship to psychopathology and environmental stressors. Eur Child Adolesc Psychiatry 13(3):141–150

    Article  PubMed  Google Scholar 

  • Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R (2012) Oxytocin during the initial stages of romantic attachment: relations to couples’ interactive reciprocity. Psychoneuroendocrinology 37(8):1277–1285

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Seltzer LJ, Ziegler TE, Pollak SD (2010) Social vocalizations can release oxytocin in humans. Proc Biol Sci 277(1694):2661–2666

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Shahrestani S, Kemp AH, Guastella AJ (2013) The impact of a single administration of intranasal oxytocin on the recognition of basic emotions in humans: a meta-analysis. Neuropsychopharmacology 38:1929–1936

  • Spratt EG, Nicholas JS, Brady KT, Carpenter LA, Hatcher CR, Meekins KA, Furlanetto RW, Charles JM (2012) Enhanced cortisol response to stress in children in autism. J Autism Dev Disord 42(1):75–81

    Article  PubMed Central  PubMed  Google Scholar 

  • Taurines R, Schmitt J, Renner T, Conner AC, Warnke A, Romanos M (2010) Developmental comorbidity in attention-deficit/hyperactivity disorder (ADHD). ADHD 2(4):267–289

    PubMed  Google Scholar 

  • Taurines R, Schwenck C, Westerwald E, Sachse M, Siniatchkin M, Freitag C (2012) ADHD and autism: differential diagnosis or overlapping traits? A selective review. Atten Defic Hyperact Disord 4(3):115–139

    Article  PubMed  Google Scholar 

  • Taylor SE, Gonzaga GC, Klein LC, Hu P, Greendale GA, Seeman TE (2006) Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom Med 68(2):238–245

    Article  CAS  PubMed  Google Scholar 

  • Taylor SE, Saphire-Bernstein S, Seeman TE (2010) Are plasma oxytocin in women and plasma vasopressin in men biomarkers of distressed pair–bond relationships? Psychol Sci 21(1):3–7

    Article  PubMed  Google Scholar 

  • Tewes U, Rossmann P, Schallberger U (1999) Hamburg-Wechsler-Intelligenztest für Kinder (HAWIK-III). Verlag Hans Huber, Bern

    Google Scholar 

  • Tops M, van Peer JM, Korf J, Wijers AA, Tucker DM (2007) Anxiety, cortisol, and attachment predict plasma oxytocin. Psychophysiology 44(3):444–449

    Article  PubMed  Google Scholar 

  • Turner RA, Altemus M, Enos T, Cooper B, McGuinness T (1999) Preliminary research on plasma oxytocin in normal cycling women: investigating emotion and interpersonal distress. Psychiatry 62(2):97–113

    CAS  PubMed  Google Scholar 

  • Uvnäs-Moberg K, Alster P, Svensson TH (1992) Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats. Psychopharmacology 109(4):473–476

    Article  PubMed  Google Scholar 

  • Uvnäs-Moberg K, Bjökstrand E, Hillegaart V, Ahlenius S (1999) Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology 142(1):95–101

    Article  PubMed  Google Scholar 

  • Wechsler D (1949) Wechsler intelligence scale for children. The Psychological Corporation, New York

    Google Scholar 

  • Weisman O, Zagoory-Sharon O, Schneiderman I, Gordon I, Feldman R (2013) Plasma oxytocin distributions in a large cohort of women and men and their gender-specific associations with anxiety. Psychoneuroendocrinology 38(5):694–701

    Article  CAS  PubMed  Google Scholar 

  • Weiß R (1998) Grundintelligenztest Skala 2 (CFT 20) mit Wortschatztest (WS) und Zahlenfolgentest (ZF). Handanweisung, 4. überarbeitete Auflage. Hogrefe, Göttingen

    Google Scholar 

  • Whitnall MH, Key S, Ben-Barak Y, Ozato K, Gainer H (1985) Neurophysin in the hypothalamo-neurohypophysial system. II. Immunocytochemical studies of the ontogeny of oxytocinergic and vasopressinergic neurons. J Neurosci 5(1):98–109

    CAS  PubMed  Google Scholar 

  • Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R, Stefansson H, Stefansson K, Magnusson P, Gudmundsson OO, Gustafsson O, Holmans P, Owen MJ, O’Donovan M, Thapar A (2010) Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376(9750):1401–1408

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Wismer Fries AB, Ziegler TE, Kurian JR, Jacoris S, Pollak SD (2005) Early experience in humans is associated with changes in neuropeptides critical for regulating social behavior. Proc Natl Acad Sci USA 102(47):17237–17240

    Article  PubMed  Google Scholar 

  • Wotjak CT, Ganster J, Kohl G, Holsboer F, Landgraf R, Engelmann M (1998) Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons. Neuroscience 85(4):1209–1222

    Article  CAS  PubMed  Google Scholar 

  • Wu S, Jia M, Ruan Y, Liu J, Guo Y, Shuang M, Gong X, Zhang Y, Yang X, Zhang D (2005) Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. Biol Psychiatry 58(1):74–77

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

We wish to thank the patients and families who participated in this study as well as Dr. Alex C. Conner for his support with manuscript preparation.

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  1. Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Füchsleinstraße 15, 97080, Würzburg, Germany

    Regina Taurines, Benjamin Lyttwin, Thomas Jans, Lennart Reefschläger, Julia Geissler, Manfred Gerlach & Marcel Romanos

  2. Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Goethe-University, Frankfurt/M., Germany

    Christina Schwenck

  3. Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany

    Martin Schecklmann

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  1. Regina Taurines
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Taurines, R., Schwenck, C., Lyttwin, B. et al. Oxytocin plasma concentrations in children and adolescents with autism spectrum disorder: correlation with autistic symptomatology. ADHD Atten Def Hyp Disord 6, 231–239 (2014). https://doi.org/10.1007/s12402-014-0145-y

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