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Potential utility of SPECT/CT with 99mTc-Tektrotyd for imaging of post-myocardial infarction inflammation

  • ORIGINAL ARTICLE
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

There is a need to develop methods for post-myocardial infarction (MI) inflammation monitoring. Scintigraphy with somatostatin receptor targeted radiotracers has potential in this field. The purpose was to study the association of 99mTc-Tektrotyd uptake intensity in MI area with heart contractility indices over 6-month follow-up.

Methods

Fourteen patients with acute ST-segment elevation anterior MI (STEMI) were examined with 99mTc-Tektrotyd SPECT/CT, myocardial perfusion scintigraphy (MPS) at rest, cardiac magnetic resonance imaging (cMRI) and transthoracic echocardiography (TTE). Scintigraphic results were compared with 6-month TTE indices.

Results

On the 7th day after a MI onset, cardiac 99mTc-Tektrotyd uptake was found in 7 of 14 patients. Median of 99mTc-Tektrotyd SUVmax was 1.59 (1.38; 2.83), the summed rest score (SRS) was 11 (5; 18), infarct size (by cMRI)—13.15 (3.3; 32.2) %. 99mTc-Tektrotyd SUVmax strongly correlated with 6-month heart contractility indices (r = 0.81, P < 0.05 for the end diastolic volume; r = 0.61 P < 0.05 for Δ end diastolic volume), with SRS (r = 0.85, P < 0.05) and infarct size (by cMRI) (r = 0.79, P < 0.05).

Conclusion

The intensity (SUVmax) of 99mTc-Tektrotyd uptake in the area of recent MI directly depends on the size of ischemic myocardial injury and correlates with changes of heart contractility indexes over the 6 month follow-up.

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Abbreviations

MI:

Myocardial infarction

STEMI:

ST-segment elevation myocardial infarction

SSTR-t:

Somatostatin receptor targeted

MPS:

Myocardial perfusion scintigraphy

TTE:

Transthoracic echocardiography

cMRI:

Cardiac magnetic resonance imaging

MVO:

Microvascular obstruction

IH:

Intramyocardial hemorrhage

LGE:

Late gadolinium enhancement

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Acknowledgments

The authors are grateful to Marina Kobozeva Marina Kobozeva and Vadim Goldman for assistance in preparing the article.

Funding

This work is supported by Russian Science Foundation, Grant No 22-25-00234.

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Authors and Affiliations

  1. Nuclear Medicine Department, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Kievskaya 111a, 634012, Russian Federation, Tomsk

    Svetlana I. Sazonova, Julia N. Ilyushenkova & Anna I. Mishkina

  2. Cardiac Emergency Department, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russian Federation

    Anna G. Syrkina, Andrey A. Trusov & Vyacheslav V. Ryabov

  3. Magnetic-Resonance Tomography Department, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russian Federation

    Olga V. Mochula

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  1. Svetlana I. Sazonova
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Correspondence to Svetlana I. Sazonova.

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Svetlana I. Sazonova, Julia N. Ilyushenkova, Anna G. Syrkina, Andrey A. Trusov, Olga V. Mochula, Anna I. Mishkina, Vyacheslav V. Ryabov declares have no conflict of interest.

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Sazonova, S.I., Ilyushenkova, J.N., Syrkina, A.G. et al. Potential utility of SPECT/CT with 99mTc-Tektrotyd for imaging of post-myocardial infarction inflammation. J. Nucl. Cardiol. 30, 2544–2555 (2023). https://doi.org/10.1007/s12350-023-03312-5

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